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Apoptosis Compound Library

Catalog No. L9000

Library Compound List Excel SDF

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. Apoptosis leads to characteristic cell changes (morphology): the cell breaks apart into multiple vesicles called apoptotic bodies, which undergo phagocytosis. Apoptosis is regulated by both pro-apoptotic (such as Fas receptor and caspases) and anti-apoptotic (such as Bcl-2 and IAP) factors. Disordered apoptosis is implicated in a variety of human diseases. Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, inflammatory diseases, and viral infections. Excessive apoptosis may also be a feature of some conditions such as autoimmune diseases, neurodegenerative diseases, and ischemia-associated injury. Consequently, considerable interest has arisen in therapeutic strategies for cancer, autoimmune diseases, and neurodegenerative diseases by modulating apoptosis pharmacologically.

TargetMol’s collection of 733 apoptosis-related compounds, Apoptosis Compound Library, is divided accordingly with compounds designed for either pro- or anti-apoptosis purposes and can be used for research in cancer and neurodegenerative diseases.

Pack Size	Price/USD
100 μL * 10 mM (in DMSO)	10910.00
250 μL * 10 mM (in DMSO)	18160.00
1 mg	18160.00

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Product Description

A unique collection of 733 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
Targets include Bcl-2, Caspase, p53, TNF-alpha, and surviving, etc.;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (927 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Library Composition

TNF (24)

Bcr-Abl (15)

p53 (14)

Mdm2 (13)

Caspase (13)

c-RET (11)

Apoptosis inducer (10)

BCL (10)

FLT (10)

NF-κB (9)

c-Kit (9)

Serine/threonin kinase (9)

VEGFR (9)

PKC (7)

IAP (7)

PKA (6)

Src (5)

IL Receptor (5)

ERK (5)

DNA/RNA Synthesis (4)

COX (4)

CDK (4)

Aurora Kinase (4)

PERK (4)

PDE (4)

Microtubule Associated (4)

PDGFR (3)

Epigenetic Reader Domain (3)

Sirtuin (3)

TAM Receptor (3)

Topoisomerase (2)

ROCK (2)

PPAR (2)

Proteasome (2)

Raf (2)

Cysteine Protease (2)

DUB (2)

FAK (2)

HDAC (2)

Histone Methyltransferase (2)

ASK (2)

Adenosine Receptor (2)

c-Met/HGFR (2)

c-Myc (2)

P450 (2)

PD-1/PD-L1 (2)

NOD (2)

LRRK2 (2)

FGFR (2)

HSP (2)

JAK (2)

JNK (1)

Lipid (1)

Lipoxygenase (1)

IGF-1R (1)

LTR (1)

MAO (1)

MAPK (1)

IκB/IKK (1)

MEK (1)

MMP (1)

p38 MAPK (1)

PAI-1 (1)

PARP (1)

Phospholipase (1)

PI3K (1)

PLK (1)

Potassium Channel (1)

CSF-1R (1)

CXCR (1)

CFTR (1)

Adrenergic Receptor (1)

Akt (1)

ALK (1)

Aminopeptidase (1)

Androgen Receptor (1)

HIV Protease (1)

HER (1)

Histone Demethylase (1)

Ferroptosis (1)

FOXO1 (1)

EGFR (1)

Ephrin Receptor (1)

Dehydrogenase (1)

Retinoid Receptor (1)

Prostaglandin Receptor (1)

ROS (1)

SGK (1)

Transferase (1)

Trk receptor (1)

Tyrosinase (1)

Tyrosine Kinases (1)

UGT (1)

STAT (1)

Survivin (1)

Telomerase (1)

Thrombin (1)

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.

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