Angiogenesis related Compound Library

Catalog No. L4800

Library Compound List Excel SDF

Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, uncontrolled angiogenesis underlies many deadly and debilitating conditions, including cancer, skin diseases, immune disorders, diabetic ulcers, cardiovascular disease, stroke, critical limb ischemia, and many others. Therefore, angiogenesis has become an attractive target for combating diseases characterized by either poor vascularization or abnormal vasculature. For example, angiogenesis plays a critical role in the growth of cancer. Tumors induce blood vessel growth (angiogenesis) by secreting various growth factors (e.g. VEGF) and proteins which induce capillary growth into the tumor, providing it with oxygen and nutrients. Angiogenesis is also required for the spread of a tumor, or metastasis. Therefore, angiogenesis inhibitors can be used to treat cancer. In addition, proangiogenic therapies are being explored as options to treat ischemic cardiovascular diseases by formation of “natural bypasses”—that is, collateral vessels.

The TargetMol’s Angiogenesis related Compound Library, a unique collection of angiogenesis related compounds, can be used for research in angiogenesis and related drug discovery.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
Targets include angiogenesis signaling, and related targets such as S1P, VEGFR, PDGF, etc.;
Includes approved drugs targeting angiogenesis, such as Sunitinib Malate, Lenalidomide, sorafenib, Erlotinib; drugs in clinical development with the most potential targeting angiogenesis, such as Vatalanib, Orantinib, 2-Methoxyestradiol (Panzem), Celecoxib;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

5-HT Receptor (248)

Apoptosis (202)

Autophagy (158)

PI3K (152)

EGFR (141)

VEGFR (136)

JAK (90)

FLT (81)

Src (81)

PDGFR (80)

Dopamine Receptor (76)

Akt (72)

FGFR (71)

TNF (63)

COX (60)

c-Kit (58)

MMP (54)

Bcr-Abl (51)

ALK (49)

RAAS (48)

mTOR (45)

Adrenergic Receptor (40)

TGF-beta/Smad (38)

Endogenous Metabolite (38)

HER (37)

NF-κB (37)

BTK (36)

Histamine Receptor (33)

Tyrosine Kinases (31)

c-Met/HGFR (30)

HIF (30)

Antibacterial (30)

IL Receptor (29)

AChR (26)

FAK (26)

DNA-PK (24)

CDK (24)

ERK (23)

HIF/HIF Prolyl-Hydroxylase (22)

Reactive Oxygen Species (22)

Serotonin Transporter (21)

c-RET (21)

Syk (20)

STAT (20)

p38 MAPK (19)

Aurora Kinase (19)

IGF-1R (18)

PKC (17)

Norepinephrine (17)

Potassium Channel (17)

Raf (16)

c-Fms (14)

Influenza Virus (14)

Parasite (14)

TAM Receptor (14)

PKA (13)

AMPK (12)

Trk receptor (12)

HIV Protease (11)

JNK (11)

ROS (11)

NO Synthase (11)

HDAC (11)

S6 Kinase (10)

MEK (10)

Drug Metabolite (9)

Virus Protease (9)

Caspase (9)

Antibiotic (8)

CSF-1R (8)

Interleukin (8)

P450 (8)

Mitophagy (8)

Tyrosinase (8)

Casein Kinase (7)

Ferroptosis (7)

Lipoxygenase (7)

ROS Kinase (7)

DNA/RNA Synthesis (7)

Sodium Channel (7)

Ephrin Receptor (6)

Prostaglandin Receptor (6)

MLK (6)

ATM/ATR (6)

GSK-3 (6)

Antifungal (6)

PDE (6)

PI4K (6)

Integrin (6)

ROCK (5)

Nrf2 (5)

Antioxidant (5)

Microtubule Associated (5)

SARS-CoV (5)

PDK (5)

PYK2 (5)

Ligand for E3 Ligase (5)

P-gp (5)

PLK (5)

PPAR (5)

Sigma receptor (5)

TLR (5)

HCV Protease (5)

Chk (5)

Carbonic Anhydrase (4)

Dehydrogenase (4)

MAPK (4)

Topoisomerase (4)

Transferase (4)

BCL (4)

Adenosine Receptor (4)

Serine/threonin kinase (4)

Histone Methyltransferase (4)

NOS (4)

IκB/IKK (4)

Tie-2 (4)

ACK (4)

HSP (4)

HSV (4)

Opioid Receptor (4)

IFNAR (4)

PARP (3)

TRP/TRPV Channel (3)

NOD (3)

Reverse Transcriptase (3)

Beta Amyloid (3)

MRP (3)

Anti-infection (3)

Glucosidase (3)

PGE Synthase (3)

Discoidin Domain Receptor (DDR) (3)

CaMK (3)

Molecular Glues (3)

Serine Protease (3)

CCR (3)

AChE (3)

Ligands for Target Protein for PROTAC (3)

Estrogen/progestogen Receptor (3)

Survivin (3)

DYRK (3)

Sirtuin (3)

Hck (3)

Proton pump (2)

PTEN (2)

Wnt/beta-catenin (2)

p53 (2)

GABA Receptor (2)

GluR (2)

ribosome (2)

VDA (2)

Calcium Channel (2)

IRAK (2)

IRE1 (2)

Leukotriene Receptor (2)

transporter (2)

SGK (2)

MAO (2)

Guanylate cyclase (2)

SGLT (2)

iGluR (2)

RIP kinase (2)

BCRP (2)

NOD-like Receptor (NLR) (2)

BACE (2)

Epigenetic Reader Domain (2)

ROR (1)

STING (1)

Stearoyl-CoA Desaturase (SCD) (1)

RSV (1)

S1P Receptor (1)

PROTACs (1)

Pyroptosis (1)

PROTAC Linker (1)

LDL (1)

PKM (1)

DNA Alkylator/Crosslinker (1)

Gap Junction Protein (1)

Gamma-secretase (1)

FXR (1)

Free radical scavengers (1)

FAAH (1)

Estrogen Receptor/ERR (1)

Epoxide Hydrolase (1)

Endothelin Receptor (1)

E1/E2/E3 Enzyme (1)

DUB (1)

DNA Alkylation (1)

GST (1)

CXCR (1)

CRISPR/Cas9 (1)

Chloride channel (1)

CFTR (1)

cell cycle arrest (1)

Beta-Secretase (1)

ATPase (1)

ATP Citrate Lyase (1)

Antifection (1)

Acyltransferase (1)

GRK (1)

HBV (1)

Pim (1)

Na+/Ca2+ Exchanger (1)

Phospholipase (1)

Phosphatase (1)

PERK (1)

PAD (1)

p97 (1)

P2X Receptor (1)

NMDAR (1)

Neprilysin (1)

NADPH-oxidase (1)

NADPH (1)

Myosin (1)

Hedgehog/Smoothened (1)

Monoamine Transporter (1)

MNK (1)

Melatonin Receptor (1)

Melanin-concentrating Hormone Receptor (MCHR) (1)

LTR (1)

LRRK2 (1)

Immunology/Inflammation related (1)

Histone Demethylase (1)

Histone Acetyltransferase (1)

Hippo pathway (1)

YAP (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty