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Phosphatase Inhibitor Cocktail II (100× DMSO)

Catalog No. C0003

It is easy for the proteins to be degraded or dephosphorylated during in vitro extraction procedure, which could cause an inaccurate result of protein expression detection. Therefore, adding protease inhibitors or phosphatase inhibitors into the extracts would be an effective method to prevent degradation and dephosphorylation of protein.

The phosphatase inhibitor mixture can effectively inhibit the dephosphorylation of common phosphatases on proteins and maintain the original phosphorylation state of proteins.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Phosphatase Inhibitor Cocktail II (100× DMSO)
Pack Size Availability Price/USD Quantity
1 mL In stock $ 34.00
1 mL * 10 In stock $ 245.00
1 mL * 50 In stock $ 997.00
1 mL * 100 In stock $ 1,492.00
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Composition

Ingredient CAS MW Concentration (100x) Target Type
(-)-p-Bromotetramisole oxalate 62284-79-1 373.22 2.5 mM Alkaline phosphatases Irreversible
Cantharidin 56-25-7 196.2 500 μM Ser/Thr phosphatases Reversible
Microcystin LR 101043-37-2 995.17 500 nM Acid and PP1 and PP2A Reversible

Features

  • Accurate Ingredients —— Clearance of components and concentrations to avoid experimental uncertainty
  • Comprehensive Protection—— Effectively inhibit various proteases to protect proteins from being degraded
  • Cost-Effective —— Lower price with higher quality

Handling Instruction

  • Compatible with Western Blot analysis, IP, Co-IP, pull-down, IF, IHC, kinase assay and etc.
  • Add concentrated cocktail at 1:100 (v/v) dilution to samples solution (such as cell lysates or tissue extracts) before assaying.
  • Briefly vortex cocktails to help facilitate the dissolution.

Notice

  • Following initial thaw, aliquot and freeze (-20°C) to avoid thawing and refreezing repeatedly.
  • If Cocktail I and Cocktail II are used together, do not mix tube I with tube II beforehand, as there may be precipitation. To avoid this, please add them step by step during experiment.

Citations

1. Li Y, Xu J, Guo X, et al.The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model.Genome Biology.2023, 24(1): 20. 2. Li B, Yang T, Liu J, et al.Genetically engineered PD-1 displaying nanovesicles for synergistic checkpoint blockades and chemo-metabolic therapy against non-small cell lung cancer.Acta Biomaterialia.2023, 161: 184-200. 3. Li J, Dang P, Li Z, et al.Peroxisomal ERK mediates Akh/glucagon action and glycemic control.Cell Reports.2023, 42(10). 4. Wu K, Zhang Y, Liu Y, et al.Phosphorylation of UHRF2 affects malignant phenotypes of HCC and HBV replication by blocking DHX9 ubiquitylation.Cell Death Discovery.2023, 9(1): 27. 5. Li W, Liang J, Li S, et al.The CXCL12-CXCR4-NLRP3 axis promotes Schwann cell pyroptosis and sciatic nerve demyelination in rats.Clinical and Experimental Immunology.2023: uxad081. 6. Tang H, Guo J, Sang B, et al. PDGFRβ Modulates Aerobic Glycolysis in Osteosarcoma HOS Cells via the PI3K/AKT/mTOR/c-Myc Pathway. Biochemistry and Cell Biology. 2021 (ja). 7. Zhang Y, Zhang J, Chen Y, et al. The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I. Proceedings of the National Academy of Sciences. 2021, 118(23). 8. Wang W, Luo X, Zhang Q, et al. Bifidobacterium infantis Relieves Allergic Asthma in Mice by Regulating Th1/Th2. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2020, 26: e920583-1. 9. Tong Y, Liu L, Wang R, et al. Berberine Attenuates Chronic Atrophic Gastritis Induced by MNNG and Its Potential Mechanism. Frontiers in Pharmacology. 2021, 12: 382 10. Wang L, Deng K, Gong L, et al. Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity. Pharmacological Research. 2020: 104955.
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