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Syringaresinol

Catalog No. TN2250 CAS 487-35-4

(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation of HIF-1α± through activation of FOXO3 is a potential therapeutic strategy for ischemia-related diseases.

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Syringaresinol, CAS 487-35-4

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Purity: 98%

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Description

In vitro

We investigated a novel function and the underlying mechanism of Syringaresinol, a lignan compound, in modulation of HIF-1 and protection against cellular damage and death in a cardiomyocyte model of I/R injury. Syringaresinol caused destabilization of HIF-1α± following H/R and then protected against hypoxia/reoxygenation (H/R)-induced cellular damage, apoptosis, and mitochondrial dysfunction in a dose-dependent manner. Knock-down of FOXO3 by specific siRNAs completely abolished the ability of Syringaresinol to inhibit HIF-1 stabilization and apoptosis caused by H/R. Syringaresinol stimulated the nuclear localization and activity of FOXO3 leading to increased expression of antioxidant genes and decreased levels of reactive oxygen species (ROS) following H/R[1]

Molecular Weight	418.44
Formula	C22H26O8
CAS No.	487-35-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α± in a FOXO3-dependent mechanism.Oncotarget. 2015 Jan 1;6(1):43-55.

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Keywords

Syringaresinol 487-35-4 PI3K/Akt/mTOR信号通路表观遗传免疫与炎症血管生成 HIF mTOR ROS Inhibitor inhibitor inhibit

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