Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AS-604850 is a selective and ATP-competitive PI3Kγ inhibitor (IC50= 2.5 μM). It has over 30-fold selectivity for PI3Kδ and PI3Kβ, and 18-fold selectivity over PI3Kα.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 225.00 | |
10 mg | Inquiry | $ 396.00 | |
25 mg | Inquiry | $ 864.00 |
Description | AS-604850 is a selective and ATP-competitive PI3Kγ inhibitor (IC50= 2.5 μM). It has over 30-fold selectivity for PI3Kδ and PI3Kβ, and 18-fold selectivity over PI3Kα. |
In vitro | AS-604850 pretreatment abolished GCDC-induced phosphorylation of Akt by 50% and inhibited apoptosis by reducing GCDC/TCDC/TLC-induced caspase-3 cleavage in rat hepatocytes. In PI3KCG-/-monocytes and THP-1 (human monocytic cell line), AS-604850 inhibited the PKB phosphorylation activated by MCP-1, it also blocked the MCP-1-mediated chemotaxis in a concentration-dependent manner. In RAW264 mouse macrophages, C5a-mediated PKB phosphorylation was inhibited by AS-604850 [1][2]. |
In vivo | In the thioglycollate-induced peritonitis model that induced multiple chemokines in vivo, oral administration of 10 mg/kg AS-604850 showed a 31% decrease in neutrophil recruitment [1]. |
Molecular Weight | 285.22 |
Formula | C11H5F2NO4S |
CAS No. | T22587 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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AS-604850 T22587 Others AS604850 AS 604850 inhibitor inhibit