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AG-490

Catalog No. T2600    CAS 133550-30-8    Synonyms: AG490, AG 490, Tyrphostin AG 490, Zinc02557947, Tyrphostin B42

AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.

Pack Size Availability Price/USD Quantity
10 mg In stock 50.00
25 mg In stock 80.00
100 mg In stock 110.00
200 mg In stock 200.00
1 mL * 10 mM (in DMSO) In stock 50.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.

Receptor:

EGFR; HER2/ErbB2; JAK2;

Chemical Information:
Molecular Weight 294.30
Formula C17H14N2O3
CAS Number 133550-30-8
Solubility

Ethanol: 6 mg/mL (20.38 mM)

DMSO: 59 mg/mL (200.47 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.