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α-Lipoic Acid

α-Lipoic Acid
α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.
Catalog No. T2930Cas No. 62-46-4
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Purity:99.76%
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α-Lipoic Acid

Catalog No. T2930Cas No. 62-46-4

α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.
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Pack SizePriceAvailabilityQuantity
500 mg$47In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Product Introduction

Bioactivity
Description
α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.
In vitro
α-Lipoic Acid (Alpha-Lipoic acid, ALA) is a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics.?It reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway.?Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01).?Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells.?α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion
In vivo
Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice.?In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05)[1]
Animal Research
C57BL/6J mice, divided into four groups, are fed an high-fat diet (HFD) for 24 weeks to induce nonalcoholic fatty liver disease (NAFLD) followed by daily administration of α-Lipoic Acid.?Then, the effects of α-Lipoic Acid on hepatic lipid accumulation in long-term HFD-fed mice are assessed[1].
AliasLipoic acid, Alphalipoic acid
Chemical Properties
Molecular Weight206.32
FormulaC8H14O2S2
Cas No.62-46-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (242.34 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8468 mL24.2342 mL48.4684 mL242.3420 mL
5 mM0.9694 mL4.8468 mL9.6937 mL48.4684 mL
10 mM0.4847 mL2.4234 mL4.8468 mL24.2342 mL
20 mM0.2423 mL1.2117 mL2.4234 mL12.1171 mL
50 mM0.0969 mL0.4847 mL0.9694 mL4.8468 mL
100 mM0.0485 mL0.2423 mL0.4847 mL2.4234 mL

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