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TargetMol | Compound Library

Mini Electrophilic Heterocyclic Fragment Library

Catalog No. L7860

Since screening electrophilic fragments has become a promising alternative to discovering and verifying new targets and generating viable chemical starting points, we designed a Mini Electrophilic Heterocyclic Fragment Library. These compounds are basically covalent MiniFrags, containing five- and six-membered nitrogen-containing heterocycles with electron-withdrawing properties that can activate small electrophilic substituents (halogen, ethynyl, vinyl, and nitrile groups). The library contains not only small electrophilic heterocycles, but also N-quaternized analogs with increased reactivity. 369 compounds in total in the Highly Solubility Covalent Heterocyclic Fragment Library

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7860

Mini Electrophilic Heterocyclic Fragment Library
sizeIn stock
  • 1 mg
  • 5 mg
  • 10 mg
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The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. Targeted covalent inhibitors and chemical probes have become part of drug discovery methods. Given the advantages of fragment-based drug discovery, screening electrophilic fragments has become a promising alternative to discover and verify new targets and generate viable chemical starting points, even for targets that are almost difficult to handle. In response to this situation, we designed a small library of heterocyclic electrophilic compounds. General technology for covalent fragment screening :

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

CDK
HCV Protease
JAK
Tyrosine Kinases

Keywords