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TargetMol | Compound Library

High Solubility FragLite Fragment Library

Catalog No. L7840

The High Solubility FragLite Fragment Library contains small halogenated fragments and halogenated peptide mimic fragments. FragLites are small halogenated fragments that can be used to effectively map drug interactions in new proteins. PepLites is a small halogenated peptide mimic, designed in parallel with FragLites to cover a wider range of drug interactions in new proteins. The highly soluble halogenated fragment library contains 796 halogenated fragment compounds.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L7840

High Solubility FragLite Fragment Library
sizeIn stock
  • 1 mg
  • 5 mg
  • 10 mg
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Product Description Product Description

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. The FragLites identify productive drug-like interactions, which are identified sensitively and unambiguously by X-ray crystallography, exploiting the anomalous scattering of the halogen substituent. This mapping of protein interaction surfaces provides an assessment of druggability and can identify efficient start points for the de novo design of hit molecules incorporating the interacting motifs. Combine fragments from FragLites to generate fragment lead compounds:

TargetMol | L7840

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

Histamine Receptor
AChR
Antibacterial
Antifungal
CDK
DNA/RNA Synthesis
DPP-4
Drug Metabolite
Endogenous Metabolite
HCV Protease
HSV
Influenza Virus
Parasite
Phospholipase
PPAR

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