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Compound Libraries Approved Drug Library

Approved Drug Library

Catalog No. L1000
  Library Compound List   Excel SDF

Traditional de novo drug discovery and development involves an HTS campaign for de novo candidate hits and requires highly specialized screening facilities and compound libraries containing several million compounds. It is a time consuming and expensive process. As the regulation for drug safety and efficacy is increasingly getting complex, the cost of developing new drugs is keeping skyrocket. Drug repositioning, also known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and has recently drawn attention and has led to several blockbuster drugs because of its high efficiency and low-cost. High-content screens, new biomarkers, noninvasive imaging techniques, and advanced in bioinformatics have created new opportunities for pursuing novel indications for approved compounds.

Approved drugs all have known and well-characterized bioactivities, safety and bioavailability – properties which could dramatically accelerate drug development and optimization. Hits from this set will provide a significant head start in any drug optimization program.

In addition, a growing number of compounds have been identified from this library that can functionally replace reprogramming transcription factors, enhance efficiency of iPSC generation and accelerate the reprogramming process by single use or a combination of several molecules.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 11710.00
250 μL * 10 mM (in DMSO) 23285.00
1 mg 23285.00
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Product Description

  • A unique collection of 2342 approved drugs for high throughput screening (HTS) and high content screening (HCS);
  • All compounds collected in this library are drugs approved by Food and Drug Administration (FDA), the European Medicine Agency (EMA), or China Food and Drug Administration (CFDA), etc;
  • An effective tool for discovering new with old drugs and new drug target identification;
  • Covers various research areas, such as Cancer, Cardiovascular disease, GPCR/G protein, Neuroscience, Membrane Transporter/Ion Channel, Microbiology & Virology, Immunology/Inflammation, Tyrosine Kinase/Adaptors, etc.
  • More detailed compound information with structure, target, activity, IC50 value, and brief introduction;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Library Customization

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Packaging and Storage

  • Powder or pre-dissolved DMSO solutions in 96 well plate with optional 2D barcode
  • Shipped with blue ice.
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Library Composition

AChR (122)
5-HT Receptor (112)
Adrenergic Receptor (111)
COX (92)
Dopamine Receptor (76)
Histamine Receptor (63)
DNA/RNA Synthesis (62)
Sodium Channel (53)
Potassium Channel (48)
Antibacterial (48)
Estrogen/progestogen Receptor (45)
Calcium Channel (39)
Topoisomerase (36)
GR (35)
ribosome (30)
PDE (30)
Vitamin (30)
Antibiotic (26)
Dehydrogenase (25)
GABA Receptor (25)
RAAS (25)
VEGFR (24)
Norepinephrine (23)
EGFR (23)
Antifection (22)
PPAR (22)
P450 (21)
Autophagy (21)
MAO (21)
HIV Protease (20)
Microtubule Associated (19)
c-Kit (18)
PDGFR (18)
Carbonic Anhydrase (17)
ATPase (17)
MRP (15)
NF-κB (15)
Opioid Receptor (15)
HCV Protease (14)
HDAC (14)
DNA Alkylation (14)
Bcr-Abl (13)
Reverse Transcriptase (13)
TNF (12)
Src (12)
Thrombin (12)
Amino Acids and Derivatives (12)
Androgen Receptor (12)
Antifungal (11)
DHFR (11)
FLT (11)
GluR (11)
IL Receptor (11)
Tyrosine Kinases (10)
Retinoid Receptor (10)
NMDAR (10)
PKC (9)
ROS (9)
Proton pump (9)
NADPH (9)
FGFR (9)
DNA gyrase (9)
DPP-4 (8)
CAT (8)
ABC (8)
HMG-CoA Reductase (8)
Thyroid hormone receptor(THR) (8)
Prostaglandin Receptor (8)
Raf (8)
P2 Receptor (7)
Transferase (7)
HBV (7)
Factor Xa (7)
Lipoxygenase (7)
JAK (7)
MMP (6)
Annexin A (6)
CaMK (6)
CDK (6)
STAT (6)
Proteasome (6)
Tyrosinase (6)
Reductase (5)
Serine Protease (5)
Phospholipase (5)
CFTR (5)
Aromatase (5)
AMPK (5)
Adenosine Receptor (5)
MPO (5)
Integrin (5)
HSV (5)
Glucocorticoid Receptor (5)
Fatty Acid Synthase (4)
HIF (4)
Hedgehog/Smoothened (4)
IκB/IKK (4)
Influenza Virus (4)
Lipid (4)
Neurokinin 1 (4)
ALK (4)
Chloride channel (4)
Endothelin Receptor (4)
DNA Methyltransferase (4)
PI3K (4)
PKA (4)
PARP (4)
NOS (4)
SGLT (4)
TRP/TRPV Channel (4)
UGT (3)
Vasopressin Receptor (3)
TAM Receptor (3)
Sirtuin (3)
NOD (3)
p38 MAPK (3)
c-Met/HGFR (3)
CXCR (3)
Cysteine Protease (3)
c-RET (3)
Cell wall (3)
AhR (3)
Antiviral (3)
Arginase (3)
Na-K-Cl cotransporter (3)
mTOR (3)
MEK (3)
Monoamine Transporter (3)
LTR (3)
HER (3)
GSK-3 (3)
GST (3)
Free radical scavengers (3)
Glucokinase (3)
GluCls (3)
GNRH Receptor (3)
GPR (3)
Glutathione reductase (2)
GlyT (2)
FXR (2)
Gap Junction Protein (2)
Histone Methyltransferase (2)
MAPK (2)
IGF-1R (2)
LDL (2)
Monocarboxylate transporter (2)
Melatonin Receptor (2)
Antioxidant (2)
BTK (2)
ACAT (2)
CCR (2)
Chk (2)
Decarboxylase (2)
DNA (2)
Ephrin Receptor (2)
Epigenetic Reader Domain (2)
Cannabinoid Receptor (2)
Nucleoside Antimetabolite/Analog (2)
Platelet aggregation (2)
PLK (2)
Protease-activated Receptor (2)
Serine/threonin kinase (2)
Phosphatase (2)
Rho (2)
ROCK (2)
TLR (2)
Syk (2)
TGF-beta/Smad (2)
VDA (1)
Somatostatin (1)
Telomerase (1)
ROR (1)
S1P Receptor (1)
S6 Kinase (1)
Sigma receptor (1)
RAR/RXR (1)
Ras (1)
PDK (1)
PED (1)
P-gp (1)
OAT (1)
NPC1L1 (1)
Nrf2 (1)
OX Receptor (1)
p53 (1)
PAFR (1)
Wnt/beta-catenin (1)
DUB (1)
cholecystokinin (1)
CRM1 (1)
CSF-1R (1)
Caspase (1)
CaSR (1)
CETP (1)
c-Fms (1)
ACK (1)
Akt (1)
advanced glycation end products (1)
Aminopeptidase (1)
Anion Exchanger (1)
cAMP (1)
Aurora Kinase (1)
BACE (1)
BCL (1)
ATM/ATR (1)
ATP Citrate Lyase (1)
N-Acetylglucosaminyltransferase (1)
NADPH-oxidase (1)
NKCC (1)
JNK (1)
lysosomal autophagy (1)
Integrase (1)
Hydrogenase (1)
Hydroxylase (1)
IAP (1)
HSP (1)
Hck (1)
Histone Demethylase (1)
GRK (1)
Glucagon Receptor (1)
Ferroptosis (1)
FAK (1)