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Ximelagatran

Name: Ximelagatran
Brand: TargetMol
SKU: T17265
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17265Cas No. 192939-46-1

Alias H-37695, H37695, H 376-95, H 37695, H 376/95, EXANTA

Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.

Ximelagatran

🥰Excellent

Purity: 99.60%

Catalog No. T17265Alias H-37695, H37695, H 376-95, H 37695, H 376/95, EXANTACas No. 192939-46-1

Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$74	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$273	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.60%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo.
In vitro	Ximelagatran, an orally administered direct thrombin inhibitor, is currently being developed for both the prophylaxis and treatment of thromboembolism. Once ingested, it is rapidly absorbed and converted into its active metabolite, Melagatran, which acts as a reversible, active-site inhibitor targeting both free and clot-bound thrombin, showcasing stable and reproducible pharmacokinetic properties. Initial research indicates Ximelagatran's promising efficacy and safety profile in preventing venous thromboembolism following total knee or hip replacement surgeries[1].
Synonyms	H-37695, H37695, H 376-95, H 37695, H 376/95, EXANTA

Chemical Properties

Molecular Weight	473.57
Formula	C₂₄H₃₅N₅O₅
Cas No.	192939-46-1
Smiles	CCOC(=O)CN[C@H](C1CCCCC1)C(=O)N1CC[C@H]1C(=O)NCc1ccc(cc1)C(\N)=N\O
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (116.14 mM), Sonication is recommended.

H2O: Insoluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1116 mL	10.5581 mL	21.1162 mL	105.5810 mL
5 mM	0.4223 mL	2.1116 mL	4.2232 mL	21.1162 mL
10 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5581 mL
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2791 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1116 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc