Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 79.00 | |
5 mg | Inquiry | $ 128.00 |
Description | Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1] |
In vitro | Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) serves as a precursor for the synthesis of BI-3663, a cereblon-based molecule that effectively degrades focal adhesion tyrosine kinase (PTK2) in human hepatocellular carcinoma (HCC) cell lines. It demonstrates potent activity, achieving more than 80% degradation across a panel of 11 HCC cell lines, with a median DC50 of 30 nM[1]. |
Synonyms | Cereblon Ligand-Linker Conjugates 22, E3 ligase Ligand-Linker Conjugates 55 |
Molecular Weight | 476.48 |
Formula | C22H28N4O8 |
CAS No. | 2328070-52-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pomalidomide-amido-PEG3-C2-NH2 2328070-52-4 Others Cereblon Ligand-Linker Conjugates 22 Pomalidomide-amido-PEG-3-C2-NH2 PomalidomideamidoPEG3C2NH2 Pomalidomide amido PEG3 C2 NH2 E3 ligase Ligand-Linker Conjugates 55 inhibitor inhibit