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BDA366

Catalog No. T3706 CAS 1821496-27-8

Synonyms: BDA 366, BDA-366

BDA-366 specifically targets the BH4 domain of Bcl2 BDA-366 and suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without obvious effects on normal hematopoietic cells or body weight.

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BDA366, CAS 1821496-27-8

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Purity: 98%

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Description	BDA-366 specifically targets the BH4 domain of Bcl2 BDA-366 and suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rγnull mice, without obvious effects on normal hematopoietic cells or body weight.
In vitro	BDA-366 induces robust apoptosis in MM(Multiple myeloma) cell lines and primary MM cells by inducing BCL2 conformational change. BDA-366 induces a conformational change in the BCL2 molecule that converts it to a death protein, and inhibits lung cancer growth in vitro and in vivo[1]. BDA-366 did not bind to other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1, indicating the specificity of its Bcl2 binding. BDA-366 induces apoptotic cell death in a Bax-dependent manner and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction[2].
Cell Research	Human MM cell lines RPMI8226 and U266 were treated with BDA366 at increasing concentrations (0, 0.1, 0.25, 0.5 μM) for 48hr. Cells were harvested, stained with Annexin V and propidium iodide (PI), and subjected to FACS analysis. Apoptotic cells were gated on the Annexin V positive population. Annexin V+PI? cells were early apoptotic cells, Annexin+PI+ cells were late apoptotic cells, and Annexin?PI+ cells were necrotic cells.(Only for Reference)

Synonyms	BDA 366, BDA-366
Molecular Weight	423.513
Formula	C24H29N3O4
CAS No.	1821496-27-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

DMSO: 84 mg/mL (198.34 mM)

Ethanol: 5 mg/mL (11.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Deng J, et al. Oncotarget. 2016, 7(19):27753-63. 2. Han B, et al. Cancer Cell. 2015, 27(6):852-63.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Anti-Cancer Active Compound Library Anti-COVID-19 Compound Library PPI Inhibitor Library Apoptosis Compound Library Bioactive Compound Library

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Keywords

BDA366 1821496-27-8 凋亡 BCL BDA 366 BDA-366 Inhibitor inhibitor inhibit

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