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Search Results for " epoxide hydrolase "

Targets

57

Compounds

3

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T12974 Soluble epoxide hydrolase inhibitor Others
Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4).
T7898 AUDA Epoxide Hydrolase
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)
T83857 Soluble Epoxide Hydrolase PROTAC 1a sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a
Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its h...
T7199 TPPU Epoxide Hydrolase
TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively)
T14557 BI-1935 Epoxide Hydrolase
BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.
T14315 AR-9281 APAU Epoxide Hydrolase
AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes
T10900 CUDA PPAR , Epoxide Hydrolase
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR...
T11147 EC5026 BPN-19186 Epoxide Hydrolase
EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
T8844 Diflapolin Others , FLAP , Epoxide Hydrolase
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
T17196 UC-1728 t-TUCB Epoxide Hydrolase
UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver).
T21859 ARM1 Aminopeptidase , Epoxide Hydrolase
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.
T15430 GSK2256294A GSK 2256294 Others , Epoxide Hydrolase
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively.
T0355 Valpromide Depamide,Valpramide,Dipropylacetamide,2-propylpentanamide Epoxide Hydrolase , HSV
Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders.
T8315 1-Cyclohexyl-3-dodecyl urea CDU,N-Cyclohexyl-N-dodecyl urea,NCND Epoxide Hydrolase
1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor.
T17158 Trans-AUCB t-AUCB Epoxide Hydrolase
trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).
T23044 N,N'-Dicyclohexylurea DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 Epoxide Hydrolase
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor.
T2716 1,3-Diphenylurea Epoxide Hydrolase
1, 3-Diphenylurea is involved with Epoxide hydrolase activity.
T63536 Dual FAAH/sEH-IN-1 FAAH , Epoxide Hydrolase
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity.
T60358 SEH inhibitor-7 Epoxide Hydrolase
sEH inhibitor-7 is a soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in human and mouse with IC 50 s of 6.2 μM and 0.15 μM, respectively. sEH inhibitor-7 is associated with anti-inflammatory active molecules.
T9832 (Rac)-EC5026 Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]- Epoxide Hydrolase
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) with Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) ...
T38367 CAY10640 sEH inhibitor-1 Epoxide Hydrolase
CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.
T68786 Orniplabin
Orniplabin, also known as SMTP-7 is a dual inhibitor of thrombolysis and soluble epoxide hydrolase. SMTP-7 promotes thrombolysis and inhibits soluble epoxide hydrolase.
T24778 SEH-IN-12 sEH inhibitor 12,sEH-inhibitor-12
sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH).
T68259 TUPS
TUPS is a selective soluble epoxide hydrolase inhibitor which protects against isoprenaline-induced cardiac hypertrophy.
T61541 SEH inhibitor-6
sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1].
T37334 (±)11,12-DiHETE
(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after a...
T13042 SWE101 Others
SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively).
T61690 MEH-IN-1
mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for...
T37226 (±)7(8)-EpDTE
(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase.
T72698 SEH inhibitor-14
sEH inhibitor-14 is a benzoxazolone-5-urea analogue. In addition, sEH inhibitor-14 is a soluble Epoxide Hydrolase (sEH) inhibitor ( IC 50 =0.39 nM) .
T37239 (±)19(20)-EpDTE
(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase.
T64136 SEH inhibitor-5
sEH inhibitor-5 is a potent inhibitor of sEH (soluble epoxide hydrolase) (IC50: 0.1 nM).
T62425 SEH inhibitor-3
sEH inhibitor-3 (compound 35) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) that acts on human sEH (Ki: 0.75 nM).
T63700 SEH inhibitor-4
sEH inhibitor-4 (compound B15) has been identified as a potent soluble epoxide hydrolase (SEH) inhibitor with a remarkable inhibitory potency of 0.03 ± 0.01 nm. Intensive structural modification efforts led to the discov...
T64291 SEH inhibitor-1
sEH inhibitor-1 (compound TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with IC50 values of 0.4 and 5.3 nM for human and murine she, respectively.
T36074 S-NEPC
Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) cata...
T38143 Elaidamide
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu...
T35493 (±)10(11)-EpDPA
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bo...
T37652 5(S),6(R)-DiHETE
5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It ...
T35496 (±)13(14)-EpDPA
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bo...
T79258 SEH inhibitor-16 Epoxide Hydrolase
sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for i...
T82452 Epoxy Fluor 7
Epoxy Fluor 7, a fluorescent substrate specific to soluble epoxide hydrolase (sEH), is utilized in the measurement of sEH activity through its hydrolysis-induced fluorescence in both human and mouse enzymes.
T72875 SEH/AChE-IN-3
sEH/AChE-IN-3 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinest...
T35497 (±)7(8)-EpDPA
Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenase...
T63398 COX-2/sEH-IN-1
COX-2/sEH-IN-1 is an orally active dual inhibitor of COX-2 (IC50: 1.24 μM) and sEH (IC50: 0.40 μM), a soluble epoxide hydrolase. COX-2/sEH-IN-1 increases anti-inflammatory effects and significantly reduces cardiovascular...
T37236 (±)17(18)-DiHETE
Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogen...
T72876 SEH/AChE-IN-4
sEH/AChE-IN-4 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholin...
T64181 SEH/AChE-IN-1
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha...
T35773 Gliotoxin-13C13 Gliotoxin-13C13
Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with...
T37503 Maresin 2 3R,14S-diHDHA
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human mac...

Compounds

Soluble epoxide hydrolase inhibitor
T12974
Synonym:
Target: Others
AUDA
T7898
Synonym:
Target: Epoxide Hydrolase
Soluble Epoxide Hydrolase PROTAC 1a
T83857
Synonym: sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a
Target:
TPPU
T7199
Synonym:
Target: Epoxide Hydrolase
BI-1935
T14557
Synonym:
Target: Epoxide Hydrolase
AR-9281
T14315
Synonym: APAU
Target: Epoxide Hydrolase
CUDA
T10900
Synonym:
Target: PPAR, Epoxide Hydrolase
EC5026
T11147
Synonym: BPN-19186
Target: Epoxide Hydrolase
Diflapolin
T8844
Synonym:
Target: Others, FLAP, Epoxide Hydrolase
UC-1728
T17196
Synonym: t-TUCB
Target: Epoxide Hydrolase
ARM1
T21859
Synonym:
Target: Aminopeptidase, Epoxide Hydrolase
GSK2256294A
T15430
Synonym: GSK 2256294
Target: Others, Epoxide Hydrolase
Valpromide
T0355
Synonym: Depamide,Valpramide,Dipropylacetamide,2-propylpentanamide
Target: Epoxide Hydrolase, HSV
1-Cyclohexyl-3-dodecyl urea
T8315
Synonym: CDU,N-Cyclohexyl-N-dodecyl urea,NCND
Target: Epoxide Hydrolase
trans-AUCB
T17158
Synonym: t-AUCB
Target: Epoxide Hydrolase
N,N'-Dicyclohexylurea
T23044
Synonym: DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582
Target: Epoxide Hydrolase
1,3-Diphenylurea
T2716
Synonym:
Target: Epoxide Hydrolase
Dual FAAH/sEH-IN-1
T63536
Synonym:
Target: FAAH, Epoxide Hydrolase
sEH inhibitor-7
T60358
Synonym:
Target: Epoxide Hydrolase
(Rac)-EC5026
T9832
Synonym: Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]-
Target: Epoxide Hydrolase
CAY10640
T38367
Synonym: sEH inhibitor-1
Target: Epoxide Hydrolase
Orniplabin
T68786
Synonym:
Target:
sEH-IN-12
T24778
Synonym: sEH inhibitor 12,sEH-inhibitor-12
Target:
TUPS
T68259
Synonym:
Target:
sEH inhibitor-6
T61541
Synonym:
Target:
(±)11,12-DiHETE
T37334
Synonym:
Target:
SWE101
T13042
Synonym:
Target: Others
mEH-IN-1
T61690
Synonym:
Target:
(±)7(8)-EpDTE
T37226
Synonym:
Target:
sEH inhibitor-14
T72698
Synonym:
Target:
(±)19(20)-EpDTE
T37239
Synonym:
Target:
sEH inhibitor-5
T64136
Synonym:
Target:
sEH inhibitor-3
T62425
Synonym:
Target:
sEH inhibitor-4
T63700
Synonym:
Target:
sEH inhibitor-1
T64291
Synonym:
Target:
S-NEPC
T36074
Synonym:
Target:
Elaidamide
T38143
Synonym:
Target:
(±)10(11)-EpDPA
T35493
Synonym:
Target:
5(S),6(R)-DiHETE
T37652
Synonym:
Target:
(±)13(14)-EpDPA
T35496
Synonym:
Target:
sEH inhibitor-16
T79258
Synonym:
Target: Epoxide Hydrolase
Epoxy Fluor 7
T82452
Synonym:
Target:
sEH/AChE-IN-3
T72875
Synonym:
Target:
(±)7(8)-EpDPA
T35497
Synonym:
Target:
COX-2/sEH-IN-1
T63398
Synonym:
Target:
(±)17(18)-DiHETE
T37236
Synonym:
Target:
sEH/AChE-IN-4
T72876
Synonym:
Target:
sEH/AChE-IN-1
T64181
Synonym:
Target:
Gliotoxin-13C13
T35773
Synonym: Gliotoxin-13C13
Target:
Maresin 2
T37503
Synonym: 3R,14S-diHDHA
Target:
1 2
Cat No. Product Name Synonyms Targets
TN6794 N-(3-methoxybenzyl)-octadecanamide Others
N-(3-methoxybenzyl)-octadecanamide deverts from Maca (Lepidium meyenii Walp.).
T37272 9(S),12(S),13(S)-TriHOME
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble ...
TN4592 Murrangatin IL Receptor , TNF , COX , Prostaglandin Receptor
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity ag...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00410 EPHX2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the ...
TMPY-00877 Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4...
TMPY-01658 Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4...
TMPJ-01326 HDHD2 Protein, Human, Recombinant (His) Human E. coli
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22 (HDHD2) is a member of the HAD-like hydrolase superfamily. HDHD2 includes L-2-Haloacid Dehalogenase, Epoxide Hydrolases and Phosphatases. There are two ac...
TargetMol