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Cat No. | Product Name | Synonyms | Targets |
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T12974 | Soluble epoxide hydrolase inhibitor | Others | |
Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). | |||
T7898 | AUDA | Epoxide Hydrolase | |
AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively) | |||
T83857 | Soluble Epoxide Hydrolase PROTAC 1a | sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a | |
Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its h... | |||
T7199 | TPPU | Epoxide Hydrolase | |
TPPU is a potent inhibitor of both human and mouse sEH (IC50 of 3.7 and 2.8 nM, respectively) | |||
T14557 | BI-1935 | Epoxide Hydrolase | |
BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease. | |||
T14315 | AR-9281 | APAU | Epoxide Hydrolase |
AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes | |||
T10900 | CUDA | PPAR , Epoxide Hydrolase | |
CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... | |||
T11147 | EC5026 | BPN-19186 | Epoxide Hydrolase |
EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators. | |||
T8844 | Diflapolin | Others , FLAP , Epoxide Hydrolase | |
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. | |||
T17196 | UC-1728 | t-TUCB | Epoxide Hydrolase |
UC-1728 (t-TUCB) is an effective rabbit soluble epoxide hydrolase inhibitor (IC50: 2 nM on rabbit liver). | |||
T21859 | ARM1 | Aminopeptidase , Epoxide Hydrolase | |
ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase. | |||
T15430 | GSK2256294A | GSK 2256294 | Others , Epoxide Hydrolase |
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. | |||
T0355 | Valpromide | Depamide,Valpramide,Dipropylacetamide,2-propylpentanamide | Epoxide Hydrolase , HSV |
Valpromide (Dipropylacetamide) is a carboxamide derivative of valproic acid, used in the treatment of epilepsy and some affective disorders. | |||
T8315 | 1-Cyclohexyl-3-dodecyl urea | CDU,N-Cyclohexyl-N-dodecyl urea,NCND | Epoxide Hydrolase |
1-Cyclohexyl-3-dodecyl urea (NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. | |||
T17158 | Trans-AUCB | t-AUCB | Epoxide Hydrolase |
trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively). | |||
T23044 | N,N'-Dicyclohexylurea | DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 | Epoxide Hydrolase |
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. | |||
T2716 | 1,3-Diphenylurea | Epoxide Hydrolase | |
1, 3-Diphenylurea is involved with Epoxide hydrolase activity. | |||
T63536 | Dual FAAH/sEH-IN-1 | FAAH , Epoxide Hydrolase | |
Dual FAAH/sEH-IN-1 is a dual inhibitor of sEH (soluble epoxide hydrolase) (IC50: 9.6 nM) and FAAH (fatty acid amide hydrolase) (IC50: 7 nM) with high affinity and anti-inflammatory activity. | |||
T60358 | SEH inhibitor-7 | Epoxide Hydrolase | |
sEH inhibitor-7 is a soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in human and mouse with IC 50 s of 6.2 μM and 0.15 μM, respectively. sEH inhibitor-7 is associated with anti-inflammatory active molecules. | |||
T9832 | (Rac)-EC5026 | Urea, N-[3-fluoro-4-(trifluoromethoxy)phenyl]-N'-[1-(2-methyl-1-oxobutyl)-4-piperidinyl]- | Epoxide Hydrolase |
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) with Ki of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) ... | |||
T38367 | CAY10640 | sEH inhibitor-1 | Epoxide Hydrolase |
CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. | |||
T68786 | Orniplabin | ||
Orniplabin, also known as SMTP-7 is a dual inhibitor of thrombolysis and soluble epoxide hydrolase. SMTP-7 promotes thrombolysis and inhibits soluble epoxide hydrolase. | |||
T24778 | SEH-IN-12 | sEH inhibitor 12,sEH-inhibitor-12 | |
sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH). | |||
T68259 | TUPS | ||
TUPS is a selective soluble epoxide hydrolase inhibitor which protects against isoprenaline-induced cardiac hypertrophy. | |||
T61541 | SEH inhibitor-6 | ||
sEH inhibitor-6 (Compound 3g) is a highly potent soluble epoxide hydrolase (sEH) inhibitor, exhibiting an IC 50 value of 0.5 nM [1]. | |||
T37334 | (±)11,12-DiHETE | ||
(±)11,12-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11,12-DiHETE are increased over baseline after a... | |||
T13042 | SWE101 | Others | |
SWE101 is a potent human and rat soluble epoxide hydrolase (sEH)-P inhibitor(IC50s of 4 μM and 2.8 μM, respectively). | |||
T61690 | MEH-IN-1 | ||
mEH-IN-1 (Compound 62) is a potent inhibitor of microsomal epoxide hydrolase (mEH), with an IC50 value of 2.2 nM. mEH is an α/β-fold hydrolase enzyme that is widely expressed in various mammalian tissues, responsible for... | |||
T37226 | (±)7(8)-EpDTE | ||
(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase. | |||
T72698 | SEH inhibitor-14 | ||
sEH inhibitor-14 is a benzoxazolone-5-urea analogue. In addition, sEH inhibitor-14 is a soluble Epoxide Hydrolase (sEH) inhibitor ( IC 50 =0.39 nM) . | |||
T37239 | (±)19(20)-EpDTE | ||
(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase. | |||
T64136 | SEH inhibitor-5 | ||
sEH inhibitor-5 is a potent inhibitor of sEH (soluble epoxide hydrolase) (IC50: 0.1 nM). | |||
T62425 | SEH inhibitor-3 | ||
sEH inhibitor-3 (compound 35) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) that acts on human sEH (Ki: 0.75 nM). | |||
T63700 | SEH inhibitor-4 | ||
sEH inhibitor-4 (compound B15) has been identified as a potent soluble epoxide hydrolase (SEH) inhibitor with a remarkable inhibitory potency of 0.03 ± 0.01 nm. Intensive structural modification efforts led to the discov... | |||
T64291 | SEH inhibitor-1 | ||
sEH inhibitor-1 (compound TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with IC50 values of 0.4 and 5.3 nM for human and murine she, respectively. | |||
T36074 | S-NEPC | ||
Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) cata... | |||
T38143 | Elaidamide | ||
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu... | |||
T35493 | (±)10(11)-EpDPA | ||
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 10,11-double bo... | |||
T37652 | 5(S),6(R)-DiHETE | ||
5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It ... | |||
T35496 | (±)13(14)-EpDPA | ||
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bo... | |||
T79258 | SEH inhibitor-16 | Epoxide Hydrolase | |
sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for i... | |||
T82452 | Epoxy Fluor 7 | ||
Epoxy Fluor 7, a fluorescent substrate specific to soluble epoxide hydrolase (sEH), is utilized in the measurement of sEH activity through its hydrolysis-induced fluorescence in both human and mouse enzymes. | |||
T72875 | SEH/AChE-IN-3 | ||
sEH/AChE-IN-3 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinest... | |||
T35497 | (±)7(8)-EpDPA | ||
Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenase... | |||
T63398 | COX-2/sEH-IN-1 | ||
COX-2/sEH-IN-1 is an orally active dual inhibitor of COX-2 (IC50: 1.24 μM) and sEH (IC50: 0.40 μM), a soluble epoxide hydrolase. COX-2/sEH-IN-1 increases anti-inflammatory effects and significantly reduces cardiovascular... | |||
T37236 | (±)17(18)-DiHETE | ||
Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogen... | |||
T72876 | SEH/AChE-IN-4 | ||
sEH/AChE-IN-4 -15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC 50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholin... | |||
T64181 | SEH/AChE-IN-1 | ||
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha... | |||
T35773 | Gliotoxin-13C13 | Gliotoxin-13C13 | |
Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with... | |||
T37503 | Maresin 2 | 3R,14S-diHDHA | |
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human mac... |
Cat No. | Product Name | Synonyms | Targets |
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TN6794 | N-(3-methoxybenzyl)-octadecanamide | Others | |
N-(3-methoxybenzyl)-octadecanamide deverts from Maca (Lepidium meyenii Walp.). | |||
T37272 | 9(S),12(S),13(S)-TriHOME | ||
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble ... | |||
TN4592 | Murrangatin | IL Receptor , TNF , COX , Prostaglandin Receptor | |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity ag... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00410 | EPHX2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the ... | |||
TMPY-00877 | Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4... | |||
TMPY-01658 | Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4... | |||
TMPJ-01326 | HDHD2 Protein, Human, Recombinant (His) | Human | E. coli |
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22 (HDHD2) is a member of the HAD-like hydrolase superfamily. HDHD2 includes L-2-Haloacid Dehalogenase, Epoxide Hydrolases and Phosphatases. There are two ac... |