Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00064 | OX40L Protein, Human, Recombinant (His)
OX40L Protein, Human, Recombinant (His)
|
Human | Human Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells,... | |||
TMPJ-00075 | CD27L Protein, Mouse, Recombinant (His)
CD27L Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular ... | |||
TMPJ-00099 | CD28 Protein, Mouse, Recombinant (hFc & His)
CD28 Protein, Mouse, Recombinant (hFc & His)
|
Mouse | Human Cells |
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signal... | |||
TMPJ-00102 | Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human,Cynomolyus | Human Cells |
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon... | |||
TMPJ-00128 | SLAMF2 Protein, Mouse, Recombinant (His)
SLAMF2 Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on... | |||
TMPJ-00130 | SLAMF2 Protein, Human, Recombinant (hFc & His)
SLAMF2 Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains ... | |||
TMPJ-00138 | 4-1BBL Protein, Human, Recombinant (His & Flag)
4-1BBL Protein, Human, Recombinant (His & Flag)
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Human | Human Cells |
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B... | |||
TMPJ-00140 | 4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00141 | 4-1BB Protein, Cynomolgus, Recombinant (hFc)
4-1BB Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros... | |||
TMPJ-00142 | 4-1BB Protein, Cynomolgus, Recombinant (His)
4-1BB Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros... | |||
TMPJ-00143 | 4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated
4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated
|
Human | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00144 | 4-1BB Protein, Human, Recombinant (hFc & His)
4-1BB Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas... | |||
TMPJ-00145 | 4-1BB Protein, Mouse, Recombinant (hFc)
4-1BB Protein, Mouse, Recombinant (hFc)
|
Mouse | Human Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte acti... | |||
TMPJ-00150 | CD40L Protein, Human, Recombinant (Mammalian)
CD40L Protein, Human, Recombinant (Mammalian)
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00151 | CD40L Protein, Human, Recombinant
CD40L Protein, Human, Recombinant
|
Human | E. coli |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00152 | CD40L Protein, Human, Recombinant (His & Avi), Biotinylated
CD40L Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00153 | CD40L Protein, Human, Recombinant (His & Flag)
CD40L Protein, Human, Recombinant (His & Flag)
|
Human | Human Cells |
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i... | |||
TMPJ-00219 | BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | Human Cells |
Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN... | |||
TMPJ-00353 | ILDR2 Protein, Human, Recombinant (His)
ILDR2 Protein, Human, Recombinant (His)
|
Human | Human Cells |
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasi... | |||
TMPJ-00421 | CD27 Protein, Human, Recombinant (hFc & His)
CD27 Protein, Human, Recombinant (hFc & His)
|
Human | Human Cells |
CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it... |