Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00422 | OX40 Protein, Mouse, Recombinant (His)
OX40 Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis o... | |||
TMPJ-00555 | B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated
B7-2 Protein, Human, Recombinant (Avi & His), Biotinylated
|
Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or C... | |||
TMPJ-00556 | B7-2 Protein, Human, Recombinant (His)
B7-2 Protein, Human, Recombinant (His)
|
Human | Human Cells |
The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or C... | |||
TMPJ-00615 | CD27 Protein, Rhesus macaque, Recombinant (hFc)
CD27 Protein, Rhesus macaque, Recombinant (hFc)
|
Rhesus macaque | Human Cells |
CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,... | |||
TMPJ-00616 | CD27 Protein, Rhesus macaque, Recombinant (His)
CD27 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus macaque | Human Cells |
CD27 antigen, also known as CD27L receptor, T-cell activation antigen CD27, T14, S152, Tp55, TNFRSF7 and Tumor necrosis factor receptor for superfamily member 7,... | |||
TMPJ-00630 | B7-1 Protein, Cynomolgus, Recombinant (hFc)
B7-1 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | Human Cells |
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-pr... | |||
TMPJ-00632 | B7-2 Protein, Cynomolgus, Recombinant (hFc)
B7-2 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | Human Cells |
T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play impo... | |||
TMPJ-00634 | CD40 Protein, Cynomolgus, Recombinant (His)
CD40 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | Human Cells |
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cel... | |||
TMPJ-00641 | B7-2 Protein, Rhesus macaque, Recombinant (His)
B7-2 Protein, Rhesus macaque, Recombinant (His)
|
Rhesus macaque | Human Cells |
T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play impo... | |||
TMPJ-00920 | CD40L Protein, Mouse, Recombinant (His)
CD40L Protein, Mouse, Recombinant (His)
|
Mouse | Human Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino ... | |||
TMPJ-00958 | B7-1 Protein, Rabbit, Recombinant (His)
B7-1 Protein, Rabbit, Recombinant (His)
|
Rabbit | Human Cells |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of ... | |||
TMPJ-00959 | B7-2 Protein, Rabbit, Recombinant (His)
B7-2 Protein, Rabbit, Recombinant (His)
|
Rabbit | Human Cells |
T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play impo... | |||
TMPJ-01420 | CD40 Protein, Cynomolgus, Recombinant (hFc)
CD40 Protein, Cynomolgus, Recombinant (hFc)
|
Cynomolgus | Human Cells |
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cel... | |||
TMPJ-01441 | OX40L Protein, Cynomolgus, Recombinant (His)
OX40L Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | Human Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and... | |||
TMPJ-01458 | OX40 Protein, Cynomolgus, Recombinant (His)
OX40 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | Human Cells |
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis o... | |||
TMPK-00063 | OX40 Ligand/TNFSF4 Trimer Protein, Human, Recombinant (His & Flag)
OX40 Ligand/TNFSF4 Trimer Protein, Human, Recombinant (His & Flag)
|
Human | HEK293 |
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L),which belongs to the tumor necrosis factor fam... | |||
TMPK-00078 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
|
Human | HEK293 |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00079 | CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His)
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His)
|
Human | HEK293 |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00080 | CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
|
Human | HEK293 |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a... | |||
TMPK-00086 | ICOS/CD278 Protein, Human, Recombinant (His)
ICOS/CD278 Protein, Human, Recombinant (His)
|
Human | HEK293 |
Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of ... |