store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activating the insulin-Akt signalling pathway and AMPK, which enhances glucose uptake.Kazinol B stimulates gene expression and secretion of adiponectin and can be used to study diabetes.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 1,760.00 |
Description | Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activating the insulin-Akt signalling pathway and AMPK, which enhances glucose uptake.Kazinol B stimulates gene expression and secretion of adiponectin and can be used to study diabetes. |
In vitro |
Kazinol B (2-20 μM ; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes.[1] Kazinol B (10-20 μM ; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation.[1] Kazinol B (2, 10 and 20 μM ; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells.[1] Kazinol B (2-20 μM ; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells.[1] Kazinol B (2-20 μM ; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts.[1] Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells.[1] Kazinol B (6.25, 12.5, 25, 50 μM ; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL).[2] |
Molecular Weight | 392.49 |
Formula | C25H28O4 |
CAS No. | 99624-27-8 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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Kazinol B 99624-27-8 Chromatin/Epigenetic Cytoskeletal Signaling Immunology/Inflammation PI3K/Akt/mTOR signaling Akt AMPK NO Synthase inhibitor inhibit