T1931 |
6H05
|
1469338-01-9
|
99.02%
|
|
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
|
T67862 |
B-Raf IN 13
|
2573782-74-6
|
98.39%
|
|
B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.
|
TN3920 |
Effusanin A
|
30220-43-0
|
98.00%
|
|
Effusanin A has antibacterial activity. It exhibits DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) ye...
|
T12556 |
PROTAC B-Raf degrader 1
|
2364367-27-9
|
98%
|
|
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
|
T78777 |
Vem-L-Cy5
|
|
98%
|
|
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAF V600...
|
T79813 |
Raf inhibitor 3
|
1662682-11-2
|
98%
|
|
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].
|
T82637 |
Cyclorasin 9A5
|
1782098-79-6
|
98%
|
|
Cyclorasin 9A5 is a cell-permeable, 11-residue cyclic peptide that orthosterically disrupts the Ras-Raf protein interaction, demonstrating an inhibition concentr...
|
TN2114 |
Pseudoginsenoside Rh2
|
1370264-16-6
|
98%
|
|
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
|
T8721 |
I-37
|
2359690-13-2
|
98%
|
|
I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino sub...
|
TN4166 |
Griffipavixanthone
|
219649-95-3
|
98%
|
|
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
|
T15804 |
LY2452473
|
1029692-15-6
|
98%
|
|
LY2452473 is an orally bioavailable and selective androgen receptor modulator.
|
T12978 |
NSC-70220
|
4551-00-2
|
98%
|
|
SOS1-IN-1 is an inhibitor of SOS1.
|
T10567 |
BMS-214662
|
195987-41-8
|
98%
|
|
BMS-214662 is a potent and selective farnesyl transferase inhibitor that induces mitochondrial apoptosis in primitive CD34+ chronic myeloid leukemia (CML) stem c...
|
T13406L |
Zabofloxacin hydrochloride
|
623574-00-5
|
98%
|
|
Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens inc...
|
T8654 |
Plx-4032
|
1029872-54-5
|
99.94%
|
|
Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
|
T11898 |
LXH254
|
1800398-38-2
|
99.92%
|
|
LXH254 is a potent C-Raf and B-Raf inhibitor.
|
T4301 |
AD80
|
1384071-99-1
|
99.9%
|
|
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
|
T16909 |
Donafenib
|
1130115-44-4
|
99.88%
|
|
Donafenib (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respe...
|
T1792 |
Regorafenib
|
755037-03-7
|
99.87%
|
|
Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active...
|
T63333 |
Uplarafenib
|
1425485-87-5
|
99.85%
|
|
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation...
|