T35528 |
TD52
|
1798328-24-1
|
99.5%
|
|
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
|
T24073 |
PTP1B-IN-4
|
765317-72-4
|
98.19%
|
|
PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
|
T3827 |
Rhein-8-glucoside calcium
|
113443-70-2
|
|
|
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine Phosp...
|
T78141 |
LFHP-1c
|
2102347-47-5
|
98%
|
|
LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral ar...
|
T78217 |
(R)-Azasetron besylate
|
2025360-91-0
|
98%
|
|
(R)-Azasetron besylate (SENS-401), an orally active calcineurin inhibitor, has been shown to mitigate cisplatin-induced hearing loss and cochlear damage [1][2].
|
T78681 |
ITH12711
|
|
98%
|
|
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
|
T78702 |
PTP1B/AKR1B1-IN-1
|
|
98%
|
|
PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s o...
|
T78703 |
PTP1B/AKR1B1-IN-2
|
|
98%
|
|
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and...
|
T79049 |
Tegeprotafib
|
2407610-46-0
|
98%
|
|
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active inhibitor targeting both PTPN2 and PTPN1B, displaying potent IC50 values at 4.4 nM for PTPN2 and 1...
|
T79160 |
PROTAC PTPN2 degrader-2
|
2912307-38-9
|
98%
|
|
PROTAC PTPN2 degrader-2 (example 187B) is a potent agent capable of degrading PTPN2, which holds potential for research in cancer and metabolic diseases [1].
|
T79161 |
PROTAC PTPN2 degrader-2 TFA
|
2912307-39-0
|
98%
|
|
PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in cance...
|
T79491 |
H-NTPDase-IN-1
|
|
98%
|
|
h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its p...
|
T79623 |
H-NTPDase-IN-5
|
2939932-93-9
|
98%
|
|
h-NTPDase-IN-5 (compound 3b) serves as a pan-inhibitor of NTPDase, exhibiting inhibitory concentration 50 (IC50) values of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPD...
|
T79634 |
LYP-IN-3
|
|
98%
|
|
LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 μM) that modulates the T-cell receptor (TCR) signaling pathway duri...
|
T79635 |
LYP-IN-4
|
|
98%
|
|
LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1...
|
T79843 |
Anticancer agent 142
|
2948338-60-9
|
98%
|
|
Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].
|
T79844 |
Anticancer agent 143
|
2948339-38-4
|
98%
|
|
Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1]....
|
T79845 |
Anticancer agent 144
|
2948340-59-6
|
98%
|
|
Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable f...
|
T79985 |
Cryptosporioptide A
|
1647101-05-0
|
98%
|
|
Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound eff...
|
T80007 |
Stevisalioside A
|
|
98%
|
|
Stevisalioside A (Compound 2), isolated from the roots of Stevia serrata, is an orally active antidiabetic agent that inhibits Protein Tyrosine Phosphatase 1B (P...
|