T16559 |
Poloxime
|
17302-61-3
|
98%
|
|
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
|
TN3247 |
7-O-Prenylscopoletin
|
13544-37-1
|
98%
|
|
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
|
T21678 |
3MB-PP1
|
956025-83-5
|
99.97%
|
|
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression...
|
T6217 |
LFM-A13
|
244240-24-2
|
99.9%
|
|
LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...
|
TN3848 |
Dihydrobaicalein
|
35683-17-1
|
99.86%
|
|
Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2.
|
T71399 |
Plogosertib
|
1137212-79-3
|
99.85%
|
|
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative...
|
T6070 |
(E/Z)-Rigosertib sodium
|
1225497-78-8
|
99.82%
|
|
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. ...
|
T6283 |
Wortmannin
|
19545-26-7
|
99.76%
|
|
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that bl...
|
T8912 |
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
|
17899-49-9
|
99.66%
|
|
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.
|
T28904 |
T521
|
891020-54-5
|
99.65%
|
|
T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.
|
T25969 |
Poloxin-2
|
321695-37-8
|
99.59%
|
|
Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.
|
T15454 |
GW843682X
|
660868-91-7
|
99.56%
|
|
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
|
T22700 |
Cyclapolin 9
|
40533-25-3
|
99.5%
|
|
Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other ...
|
T17008 |
TC-S 7005
|
1082739-92-1
|
99.44%
|
|
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
|
T2438 |
HMN-214
|
173529-46-9
|
99.28%
|
|
HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
|
T16560 |
Poloxin
|
321688-88-4
|
99.19%
|
|
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).
|
T2634 |
Ro3280
|
1062243-51-9
|
99.19%
|
|
Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
|
T0973 |
Pyridoxine
|
65-23-6
|
99.18%
|
|
Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still ...
|
T5818 |
Rigosertib sodium
|
592542-60-4
|
99.07%
|
|
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
|
T6338 |
PHA-680632
|
398493-79-3
|
99.03%
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGF...
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