T16009 |
(Rac)-Managlinat dialanetil
|
347870-26-2
|
98.52%
|
|
(Rac)-Managlinat dialanetil ((Rac)-MB06322) is the racemate of Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FB...
|
T78238 |
4′-DTMP
|
21253-58-7
|
98%
|
|
4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits E...
|
T14147 |
Pelitrexol
|
446022-33-9
|
98%
|
|
Pelitrexol (AG 2037) is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor.
|
T17257 |
WR99210
|
47326-86-3
|
98%
|
|
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P....
|
T11921 |
LY 222306
|
154446-98-7
|
98%
|
|
LY 222306 is a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor with a Ki of 0.77 nM.
|
T0189L |
Pemetrexed disodium
|
150399-23-8
|
99.92%
|
|
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer an...
|
T0748 |
Sulfameter
|
651-06-9
|
99.85%
|
|
Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
|
T1153 |
Trimethoprim
|
738-70-5
|
99.81%
|
|
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor...
|
T0849 |
Pyrimethamine
|
58-14-0
|
99.74%
|
|
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
|
T15827 |
LY 345899
|
10538-99-5
|
99.69%
|
|
LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHF...
|
T24644 |
Piritrexim
|
72732-56-0
|
99.68%
|
|
Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma an...
|
T73328L |
P 218
|
1142407-60-0
|
99.50%
|
|
P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.
|
T61486 |
DHFR-IN-4
|
2820126-49-4
|
99.41%
|
|
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.
|
T2204 |
Diaveridine
|
5355-16-8
|
99.19%
|
|
Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to m...
|
T6226 |
Pemetrexed disodium hemipenta hydrate
|
357166-30-4
|
99.16%
|
|
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Diso...
|
T37655 |
DS44960156
|
2361327-08-2
|
99.13%
|
|
DS44960156 is a novel selective inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) that inhibits both MTHFD2 and MTHFD1 and can be used in cancer re...
|
T4558 |
Trioxsalen
|
3902-71-4
|
98.96%
|
|
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
|
T25886 |
Methotrexate Diglutamate
|
41600-13-9
|
98.84%
|
|
Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor.
|
T6120 |
Pralatrexate
|
146464-95-1
|
98.56%
|
|
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carr...
|
T11103 |
DS18561882
|
2227149-22-4
|
98.46%
|
|
DS18561882 is an orally available, selective and potent inhibitor of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) with antitumor activity, inhibits MTHFD1 ...
|