T16346 |
NS1652
|
1566-81-0
|
99.95%
|
|
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
|
T13536 |
Afoxolaner
|
1093861-60-9
|
99.93%
|
|
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA...
|
T4503 |
Talniflumate
|
66898-62-2
|
99.93%
|
|
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell cultu...
|
T4330 |
CaCCinh-A01
|
407587-33-1
|
99.92%
|
|
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
|
T0693 |
Niflumic acid
|
4394-00-7
|
99.79%
|
|
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
|
T10979 |
DCPIB
|
82749-70-0
|
99.76%
|
|
DCPIB, a known specific and potent inhibitor of volume-regulated anion channels (VRAC),DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM,...
|
T0858 |
Flufenamic acid
|
530-78-9
|
99.71%
|
|
Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint ...
|
T61051 |
ANO1-IN-1
|
407587-01-3
|
99.66%
|
|
ANO1-IN-1, a selective ANO1 channel blocker, inhibited ANO1 and ANO2 with IC50 values of 2.56 μM and 15.43 μM, respectively.ANO1-IN-1 had a significant inhibitor...
|
T0051 |
Urethane
|
51-79-6
|
99.63%
|
|
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
|
T22330 |
Fenamic acid
|
91-40-7
|
99.61%
|
|
Fenamic acid (N-Phenylanthranilic acid) is a chloride channel blocker that causes renal papillary necrosis in rats. Fenamic acid serves as a parent structure for...
|
T8960 |
MONNA
|
1572936-83-4
|
99.47%
|
|
MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.
|
TN1035 |
Irisolidone
|
2345-17-7
|
99.46%
|
|
Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
|
T12788 |
R(+)-IAA-94
|
54197-31-8
|
99.22%
|
|
R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antib...
|
T2498 |
Adjudin
|
252025-52-8
|
99.05%
|
|
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
|
T21615 |
Guanidinoethyl sulfonate
|
543-18-0
|
98.9%
|
|
Guanidinoethyl sulfonate (Taurocyamine) is a competitive glycine receptor antagonist.
|
T6307 |
Lubiprostone
|
136790-76-6
|
98.83%
|
|
Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.
|
T26630 |
Ani9
|
356102-14-2
|
98.72%
|
|
Ani9 is a high selective blocker of Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) with an IC50 of 77 nM and can be used in studies about ANO1 and the tre...
|
T15192 |
Eact
|
461000-66-8
|
98.62%
|
|
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception an...
|
T1125 |
Shikonin
|
517-89-5
|
98.54%
|
|
Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...
|
T0954 |
Halothane
|
151-67-7
|
98.50%
|
|
Halothane (Anestan) is a nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may n...
|