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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1018 Prednisone 53-03-2 99.69%
Prednisone
Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
T21911 Rilmenidine hemifumarate 207572-68-7 99.54%
Rilmenidine hemifumarate
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy...
T63228 Simmiparib 1551355-46-4 99.51%
Simmiparib
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cyc...
T35528 TD52 1798328-24-1 99.5%
TD52
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
T8199 (±)-α-Bisabolol 515-69-5 99.44%
(±)-α-Bisabolol
(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, ant...
T77732 HFY-4A 2094810-82-7 99.22%
HFY-4A
HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.
T10964L DB1976 dihydrochloride 2369663-93-2 99.08%
DB1976 dihydrochloride
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and...
T10177 (5Z,2E)-CU-3 1815598-71-0 99.02%
(5Z,2E)-CU-3
(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM....
T14846 Bz 423 216691-95-1 98.89%
Bz 423
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c rele...
T14378 AZD5582 1258392-53-8 98.83%
AZD5582
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
T9175 Casein Kinase inhibitor A51 2079068-74-7 98.42%
Casein Kinase inhibitor A51
Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be u...
T16551 Pladienolide B 445493-23-2 98.27%
Pladienolide B
Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.P...
T11146 EC359 2012591-09-0 98.11%
EC359
EC359 is a potent and selective inhibitor of leukemia inhibitory factor receptor (LIFR), a potent inhibitor with anticancer activity, blocks LIF/LIFR interaction...
TN3910 Ecdysone 3604-87-3 100%
Ecdysone
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
T3S0541 Curzerene 17910-09-7
Curzerene
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apopt...
TN2091 Polygalacin D 66663-91-0
Polygalacin D
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
T1947 BS-181 1092443-52-1
BS-181
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
T3340 SCR7 1533426-72-0
SCR7
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
T4S1499 Ginsenoside Rk1 494753-69-4
Ginsenoside Rk1
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
T3081L EPZ004777 hydrochloride 1380316-03-9
EPZ004777 hydrochloride
EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
Prednisone
T1018
Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Rilmenidine hemifumarate
T21911
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy...
Simmiparib
T63228
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cyc...
TD52
T35528
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
(±)-α-Bisabolol
T8199
(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, ant...
HFY-4A
T77732
HFY-4A is a novel HDAC inhibitor.HFY-4A has antitumour activity and has shown antiproliferative activity in breast cancer cells.
DB1976 dihydrochloride
T10964L
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and...
(5Z,2E)-CU-3
T10177
(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM....
Bz 423
T14846
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c rele...
AZD5582
T14378
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.
Casein Kinase inhibitor A51
T9175
Casein Kinase inhibitor A51 is an orally active casein kinase 1α (CK1α) inhibitor with anticancer activity that induces apoptosis in leukemia cells, and may be u...
Pladienolide B
T16551
Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.P...
EC359
T11146
EC359 is a potent and selective inhibitor of leukemia inhibitory factor receptor (LIFR), a potent inhibitor with anticancer activity, blocks LIF/LIFR interaction...
Ecdysone
TN3910
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
Curzerene
T3S0541
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apopt...
Polygalacin D
TN2091
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS...
BS-181
T1947
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
SCR7
T3340
SCR7, a specific DNA Ligase IV inhibitor, blocks nonhomologous end-joining (NHEJ).
Ginsenoside Rk1
T4S1499
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
EPZ004777 hydrochloride
T3081L
EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
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