Cat. No. | Product name | CAS No. | Purity | Chemical Structure |
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T61424 | OD36 hydrochloride | 2387510-88-3 | 99.85% |
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OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ... | ||||
T13138 | TGFBR1-IN-1 | 2170830-26-7 | 98% |
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TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM). | ||||
T15262 | Vactosertib Hydrochloride | 1352610-25-3 | 98% |
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Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ... | ||||
T10283 | ALK-IN-5 | 2351929-66-1 | 98% |
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ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM). | ||||
T13781 | MS4077 | 2230077-10-6 | 98% |
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MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK). | ||||
T10442 | A 83-01 sodium salt | 2828431-89-4 | 98% |
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A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and... | ||||
T13421 | (-)-Cevimeline hydrochloride hemihydrate | 98% |
|
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Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is being explored as a potential treatment for xerostomia in Sjogren's ... | ||||
T10426 | AZ12601011 | 2748337-86-0 | 98% |
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AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ... | ||||
T76858 | Ascrinvacumab | 1463459-96-2 | SDS-PAGE:95% SEC-HPLC:98.18% |
Ascrinvacumab
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Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has ... | ||||
T1791L | Ceritinib dihydrochloride | 1380575-43-8 | 99.99% |
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Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ... | ||||
T1936 | Alectinib | 1256580-46-7 | 99.97% |
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Alectinib (RG-7853) is an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. | ||||
T3061 | Lorlatinib | 1454846-35-5 | 99.93% |
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Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1... | ||||
T2251 | NVP-TAE 684 | 761439-42-3 | 99.91% |
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NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM). | ||||
T8152 | 6-Demethoxytangeretin | 6601-66-7 | 99.89% |
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6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa. | ||||
T1726 | SB-431542 | 301836-41-9 | 99.87% |
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SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other... | ||||
T4071 | Repotrectinib | 1802220-02-5 | 99.86% |
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Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec... | ||||
T1944 | LDN-214117 | 1627503-67-6 | 99.85% |
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LDN-214117 is a potent and selective ALK2 inhibitor. | ||||
T4975 | SM 16 | 614749-78-9 | 99.81% |
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SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM). | ||||
T2449 | D4476 | 301836-43-1 | 99.8% |
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D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay). | ||||
T6496 | Vactosertib | 1352608-82-2 | 99.78% |
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Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn... |