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BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated

Catalog No. TMPY-05567
Synonyms: tumor necrosis factor receptor superfamily member 17, BCMA, TNFRSF13A, CD269, BCM

BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated is expressed in HEK293 mammalian cells with His and Fc tag. The accession number is NP_001183.2.

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BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated
Pack Size Availability Price/USD Quantity
25 μg 5 days $ 385.00
100 μg 5 days $ 930.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated is expressed in HEK293 mammalian cells with His and Fc tag. The accession number is NP_001183.2.
Species Human
Expression System HEK293 Cells
Tag His, Fc
Accession Number NP_001183.2
Synonyms tumor necrosis factor receptor superfamily member 17, BCMA, TNFRSF13A, CD269, BCM
Construction Recombinant Human BCMA/TNFRSF17 (NP_001183.2, extracellular domain, Met 1-Ala 54) are conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Formulation Aqueous solution containing 0.5% BSA and 0.03% Proclin 300
Stability & Storage

This reagent is stable for 6 months when stored at 2℃ - 8℃. Protected from prolonged exposure to light. Do not freeze !

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Research Background Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

References and Literature

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Keywords

BCMA/TNFRSF17 Protein, Human (His & hFc), FITC conjugated tumor necrosis factor receptor superfamily member 17 BCMA TNFRSF13A CD 269 CD269 CD-269 BCM recombinant recombinant-proteins proteins protein

 

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