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NO PAINS Compound Library

Catalog No. L4020
  Library Compound List   Excel SDF

High-throughput screening is an important research tool in drug discovery, which allows rapid testing of a large number of compounds to identify target compounds, where the potent compounds can act precisely at specific protein binding sites to inhibit or activate protein function. However, some compounds were found in high-throughput screening experiments that were not based on the specific interaction between the compound and the protein and showed false positive results for "activity" in different types of target screenings. These compounds are called PAINS, the abbreviation for “Pan-assay interference compounds”. Common PAINS compounds include toxoflavin, isothiazolones, rhodanines, enones etc. Since first publication in 2010 by John Bell, PAINS filters have become widely recognized by the drug discovery industry.

For scientists who needed the PAINS filter, TargetMol created the L4020 NO-PAINS Compound Library that applied the PAINS filter, remaining 9384 small molecules that are suitable for new drug development, signaling pathway research, drug repurposing and other research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
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Product Description

  • 9384 PAINS-excluded small molecules for high-throughput screening and high-content screening.
  • Diverse targets with wide coverage; covers multiple disease research areas such as cancer, metabolism, immune system and cardiovascular system.
  • An effective tool for drug repurposing and cell-induced target screening.
  • Detailed instructions, compound structures, target information, activity descriptions, etc.
  • Structural diversity, significant druggability and cell penetration.
  • NMR, HPLC/ LCMS testings to ensure accurate structure and high purity.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (2.39 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L4020)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
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Library Composition

Apoptosis (864)
Autophagy (692)
Antibacterial (676)
Endogenous Metabolite (616)
Antibiotic (463)
5-HT Receptor (231)
Parasite (209)
AChR (206)
Antifungal (201)
COX (195)
NF-κB (184)
DNA/RNA Synthesis (159)
Adrenergic Receptor (156)
HIV Protease (148)
Potassium Channel (145)
Dopamine Receptor (144)
PI3K (137)
CDK (136)
Calcium Channel (135)
Reactive Oxygen Species (122)
VEGFR (118)
P450 (114)
EGFR (110)
Histamine Receptor (110)
Sodium Channel (104)
Dehydrogenase (101)
Epigenetic Reader Domain (101)
Influenza Virus (100)
GABA Receptor (93)
PDE (91)
HDAC (89)
PPAR (84)
Histone Methyltransferase (82)
Estrogen/progestogen Receptor (80)
Ferroptosis (79)
GluR (78)
Microtubule Associated (77)
TRP/TRPV Channel (76)
p38 MAPK (73)
JAK (73)
Antioxidant (72)
FLT (72)
AChE (71)
mTOR (71)
TNF (70)
ERK (69)
PDGFR (68)
Estrogen Receptor/ERR (68)
Opioid Receptor (67)
Src (67)
Phosphatase (64)
RAAS (64)
GPR (64)
AMPK (63)
FGFR (63)
PARP (62)
Akt (62)
iGluR (61)
Topoisomerase (61)
SARS-CoV (59)
c-Kit (58)
Caspase (58)
STAT (57)
Prostaglandin Receptor (56)
Wnt/beta-catenin (56)
Raf (56)
HCV Protease (56)
Proteasome (56)
Virus Protease (55)
Adenosine Receptor (55)
PKC (54)
c-Met/HGFR (54)
IL Receptor (53)
MMP (51)
NO Synthase (48)
Glucocorticoid Receptor (48)
Mitophagy (48)
Ras (47)
NMDAR (47)
ATPase (47)
Bcr-Abl (47)
TGF-beta/Smad (47)
ALK (46)
GSK-3 (46)
HSV (45)
BCL (45)
Androgen Receptor (45)
Beta Amyloid (45)
Mitochondrial Metabolism (43)
HBV (42)
Anti-infection (42)
TLR (41)
HSP (41)
Nucleoside Antimetabolite/Analog (41)
Tyrosinase (40)
MEK (39)
Sirtuin (38)
Aurora Kinase (37)
Phospholipase (37)
MAO (37)
Drug Metabolite (37)
JNK (36)
ROS (36)
Interleukin (35)
Reverse Transcriptase (35)
HIF/HIF Prolyl-Hydroxylase (35)
P-gp (34)
MAPK (34)
Cannabinoid Receptor (33)
DNA-PK (33)
PKA (33)
Monoamine Oxidase (33)
IκB/IKK (33)
BTK (32)
Lipoxygenase (32)
HER (32)
Tyrosine Kinases (32)
Antiviral (31)
ROCK (31)
Integrin (31)
Serotonin Transporter (31)
Serine/threonin kinase (30)
ribosome (29)
NOS (29)
Carbonic Anhydrase (29)
CaMK (28)
CXCR (28)
Nrf2 (28)
E1/E2/E3 Enzyme (28)
p53 (27)
Gamma-secretase (27)
TAM Receptor (27)
Casein Kinase (27)
Histone Demethylase (26)
c-RET (26)
Trk receptor (26)
CCR (26)
HIF (25)
P2X Receptor (25)
LPL Receptor (25)
Serine Protease (25)
IGF-1R (24)
FAK (24)
Neurokinin receptor (24)
Antifection (24)
Chloride channel (23)
Retinoid Receptor (23)
Norepinephrine (23)
DUB (23)
S6 Kinase (23)
S1P Receptor (23)
Cysteine Protease (22)
ATM/ATR (22)
Ligand for E3 Ligase (22)
Fatty Acid Synthase (21)
Histone Acetyltransferase (21)
Hedgehog/Smoothened (21)
Transferase (21)
Proton pump (21)
DPP-4 (20)
Progesterone Receptor (20)
Glucagon Receptor (20)
c-Fms (20)
Amino Acids and Derivatives (20)
DNA Alkylator/Crosslinker (20)
Indoleamine 2,3-Dioxygenase (IDO) (20)
Glucosidase (19)
FXR (19)
Chk (19)
Thyroid hormone receptor(THR) (19)
HMG-CoA Reductase (19)
PLK (19)
NADPH (19)
FAAH (19)
RIP kinase (18)
Reductase (18)
Protease-activated Receptor (18)
DNA Methyltransferase (17)
transporter (17)
Guanylate cyclase (17)
Aryl Hydrocarbon Receptor (17)
LRRK2 (17)
Smo (16)
PDK (16)
NOD (16)
Thrombin (16)
GNRH Receptor (16)
Melanocortin Receptor (15)
Acyltransferase (15)
AhR (15)
Kinesin (15)
PERK (15)
NOD-like Receptor (NLR) (14)
Neuropeptide Y Receptor (14)
P2Y Receptor (14)
Glucokinase (14)
STING (14)
OX Receptor (14)
Sigma receptor (14)
Endothelin Receptor (14)
MRP (14)
Syk (13)
Lipase (13)
CFTR (13)
Factor Xa (13)
Glutathione Peroxidase (13)
SGLT (13)
DNA Alkylation (13)
BACE (13)
Epoxide Hydrolase (13)
Antifolate (13)
Bradykinin Receptor (13)
Mdm2 (12)
IRE1 (12)
ROR (12)
Rho (12)
Immunology/Inflammation related (12)
c-Myc (12)
Vasopressin Receptor (12)
DHFR (12)
PGE Synthase (12)
IRAK (11)
Complement System (11)
PROTAC Linker (11)
ABC (11)
DNA gyrase (11)
Hydroxylase (11)
Beta-Secretase (11)
CSF-1R (11)
Aminopeptidase (11)
LTR (10)
LPA Receptor (10)
GPCR19 (10)
Ephrin Receptor (10)
Liver X Receptor (10)
Pim (10)
Stearoyl-CoA Desaturase (SCD) (10)
Isocitrate Dehydrogenase (IDH) (10)
PAK (10)
DNA (9)
Myosin (9)
IDO (9)
GHSR (9)
PD-1/PD-L1 (9)
Leukotriene Receptor (9)
ROS Kinase (9)
Gap Junction Protein (9)
IAP (9)
cholecystokinin (8)
Aromatase (8)
NAMPT (8)
Acetyl-CoA Carboxylase (8)
CAT (8)
IFNAR (8)
Phosphorylase (8)
DYRK (8)
Xanthine Oxidase (8)
Monocarboxylate transporter (8)
PAD (8)
Arginase (8)
RSV (8)
Lipid (8)
PAI-1 (7)
MLK (7)
Neprilysin (7)
UGT (7)
Monoamine Transporter (7)
cAMP (7)
GST (7)
Discoidin Domain Receptor (DDR) (7)
Melatonin Receptor (7)
ATP Citrate Lyase (7)
Porcupine (7)
YAP (6)
Imidazoline Receptor (6)
Ligands for Target Protein for PROTAC (6)
PKM (6)
Neurotensin Receptor (6)
Tie-2 (6)
p97 (6)
CaSR (6)
GTPase (6)
PI4K (6)
Telomerase (6)
BCRP (6)
Platelet aggregation (6)
Oxytocin Receptor (6)
MNK (6)
CRM1 (6)
GRK (6)
NPC1L1 (5)
SGK (5)
PROTACs (5)
DprE1 (5)
CRISPR/Cas9 (5)
CGRP Receptor (5)
Na+/Ca2+ Exchanger (5)
Somatostatin (5)
LDL (5)
LIM Kinase (5)
PYK2 (5)
CETP (5)
OCT (5)
MT Receptor (5)
Arrestin (5)
Free radical scavengers (5)
ACK (5)
Adenosine deaminase (4)
TOPK (4)
Bombesin Receptor (4)
APC (4)
GlyT (4)
Adenylyl cyclase (4)
OAT (4)
cGAS (4)
ASK (4)
advanced glycation end products (4)
FLAP (4)
Carboxypeptidase (4)
Glutaminase (4)
Annexin A (4)
cell cycle arrest (4)
PAFR (4)
PTEN (3)
Pyroptosis (3)
MTH1 (3)
SIK (3)
Molecular Glues (3)
Hexokinase (3)
BMI-1 (3)
Kisspeptin (3)
Adiponectin receptor (3)
MELK (3)
MAGL (3)
GPX (3)
Decarboxylase (3)
OXPHOS (3)
Cell wall (3)
Hippo pathway (3)
Dynamin (3)
NEDD8 (3)
Thrombopoietin Receptor (3)
KLF (3)
TSH Receptor (3)
Methionine Adenosyltransferase (MAT) (3)
CRFR (3)
MyD88 (3)
E3 Ligase Ligand-Linker Conjugate (3)
Survivin (2)
Na-K-Cl cotransporter (2)
Haspin Kinase (2)
lysosomal autophagy (2)
CD73 (2)
MALT (2)
GluCls (2)
VDAC (2)
NADPH-oxidase (2)
Wee1 (2)
Glutathione reductase (2)
Melanin-concentrating Hormone Receptor (MCHR) (2)
Galectin (2)
Piezo Channel (2)
Amylin Receptor (2)
RANKL/RANK (2)
KSP (2)
Integrase (2)
Hck (2)
Aquaporin (2)
Apelin receptor (2)
RAR/RXR  (2)
EBI2/GPR183 (2)
VDA (2)
PGC-1α (2)
Stemness kinase (1)
Prolyl Endopeptidase (PREP) (1)
hCE (1)
FOXO1 (1)
Amylase (1)
CYP19A1 (1)
Motilin Receptor (1)
ATTECs (1)
LHRH (1)
gp120/CD4 (1)
CD38 (1)
Hydrogenase (1)
Thioredoxin (1)
Transaminase (1)
HCN Channel (1)
Fer/FerT kinase (1)
Taste receptor (1)
Anion Exchanger (1)
NMU2R (1)
AAK1 (AP2 associated kinase 1) (1)
aconitase (1)
N-Acetylglucosaminyltransferase (1)
FABP (1)
Fas/FasL (1)
PACAP (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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