TN1033 |
Sennidin A
|
641-12-3
|
100%
|
|
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
|
TN1034 |
Sennidin B
|
517-44-2
|
|
|
Sennidin B stimulates glucose incorporation in rat adipocytes.
|
T4S1499 |
Ginsenoside Rk1
|
494753-69-4
|
|
|
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
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T12466 |
AZD3458
|
2132961-46-5
|
98%
|
|
AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).
|
T12463 |
PI3kδ inhibitor 1
|
1332075-63-4
|
98%
|
|
PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).
|
T78092 |
UCL-TRO-1938
|
2919575-27-0
|
98%
|
|
UCL-TRO-1938, a potent allosteric activator of PI3Kα, exhibits an EC50 of approximately 60 μM. This compound promotes cell proliferation and possesses both cardi...
|
T78211 |
STX-478
|
2883540-92-7
|
98%
|
|
STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor regression...
|
T78568 |
PI3Kδ-IN-15
|
870281-17-7
|
98%
|
|
PI3Kδ-IN-15 (compound 6b) is a potent and selective inhibitor of PI3Kδ, exhibiting an IC50 of 0.5 nM for p110δ and demonstrating over 30-fold selectivity compare...
|
T78691 |
PI3Kδ-IN-12
|
|
98%
|
|
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4 f...
|
T78804 |
PI3Kα-IN-12
|
|
98%
|
|
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values o...
|
T78836 |
IHMT-PI3K-455
|
|
98%
|
|
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3...
|
T78853 |
PI3K-IN-47
|
|
98%
|
|
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50) values...
|
T79111 |
PI3Kγ inhibitor 7
|
2575863-25-9
|
98%
|
|
PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. ...
|
T79370 |
FD2056
|
2685870-87-3
|
98%
|
|
FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Additio...
|
T79482 |
Anticancer agent 137
|
|
98%
|
|
Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis. It increases le...
|
T79566 |
PI3K-IN-41
|
|
98%
|
|
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV light irradiati...
|
T79627 |
PI3Kδ-IN-13
|
1686137-02-9
|
98%
|
|
PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including ca...
|
T79658 |
PI3Kδ-IN-14
|
|
98%
|
|
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of P...
|
T79685 |
PI3Kα-IN-13
|
2955529-67-4
|
98%
|
|
PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, e...
|
T81264 |
RLY-2608
|
2733573-94-7
|
98%
|
|
RLY-2608 is a pioneering, mutant-selective allosteric inhibitor of class IA PI3Kα (phosphoinositide 3-kinase alpha) [1].
|