PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
TN1033	Sennidin A	641-12-3	100%
TN1033	Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1034	Sennidin B	517-44-2
TN1034	Sennidin B stimulates glucose incorporation in rat adipocytes.
T12466	AZD3458	2132961-46-5	98%
T12466	AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).
T12463	PI3kδ inhibitor 1	1332075-63-4	98%
T12463	PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).
T78092	UCL-TRO-1938	2919575-27-0	98%
T78092	UCL-TRO-1938, a potent allosteric activator of PI3Kα, exhibits an EC50 of approximately 60 μM. This compound promotes cell proliferation and possesses both cardi...
T78211	STX-478	2883540-92-7	98%
T78211	STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumor regression...
T78568	PI3Kδ-IN-15	870281-17-7	98%
T78568	PI3Kδ-IN-15 (compound 6b) is a potent and selective inhibitor of PI3Kδ, exhibiting an IC50 of 0.5 nM for p110δ and demonstrating over 30-fold selectivity compare...
T78691	PI3Kδ-IN-12		98%
T78691	PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4 f...
T78804	PI3Kα-IN-12		98%
T78804	PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values o...
T78836	IHMT-PI3K-455		98%
T78836	IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM for PI3...
T78853	PI3K-IN-47		98%
T78853	PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50) values...
T79111	PI3Kγ inhibitor 7	2575863-25-9	98%
T79111	PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1]. ...
T79370	FD2056	2685870-87-3	98%
T79370	FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Additio...
T79482	Anticancer agent 137		98%
T79482	Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis. It increases le...
T79566	PI3K-IN-41		98%
T79566	PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV light irradiati...
T79627	PI3Kδ-IN-13	1686137-02-9	98%
T79627	PI3Kδ-IN-13 (compound 89), with an IC50 value of 2.6 nM, is an inhibitor of PI3Kδ, applicable for researching diseases involving cell proliferation, including ca...
T79658	PI3Kδ-IN-14		98%
T79658	PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of P...
T79685	PI3Kα-IN-13	2955529-67-4	98%
T79685	PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, e...
T81264	RLY-2608	2733573-94-7	98%
T81264	RLY-2608 is a pioneering, mutant-selective allosteric inhibitor of class IA PI3Kα (phosphoinositide 3-kinase alpha) [1].
T81453	PITCOIN4		98%
T81453	PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivity ag...