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Search Result

Search Results for " histone-methyltransferase "

Targets

Histone Methyltransferase Antifolate Histamine Receptor

117

Compounds

2

Natural Products

14

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8548 Metoprine Histone Methyltransferase , Antifolate , Histamine Receptor
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T8381 Amodiaquine Others , Histone Methyltransferase , Parasite
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
T2435 EPZ011989 Histone Methyltransferase
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.
TQ0100 AZ505 Histone Methyltransferase
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
T15194 EBI-2511 Histone Methyltransferase
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
T2097 C-7280948 C7280948 Histone Methyltransferase
C-7280948 is a PRMT1 inhibitor.
T1905 EPZ005687 Histone Methyltransferase
EPZ005687 is a potent and selective inhibitor of EZH2.
T6900 MS023 Histone Methyltransferase
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.
T3084 SGC707 Histone Methyltransferase
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
T7089 SGC2085 Histone Methyltransferase
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).
T7403 BAY-598 Histone Methyltransferase
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM.
T1775 GSK503 Histone Methyltransferase
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.
T3081 EPZ004777 Apoptosis , Histone Methyltransferase
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T6059 GSK343 Histone Methyltransferase , Autophagy
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases.
T15624 JNJ-64619178 Histone Methyltransferase
JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
T3057 UNC1999 Histone Methyltransferase , Autophagy
UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).
T4021 UNC3866 Histone Methyltransferase
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T15201 MAK683 Histone Methyltransferase
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
T5322 BCI-121 Histone Methyltransferase
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
T9584 UNC6934 Others , Histone Methyltransferase
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
T10205 A-395 Histone Methyltransferase
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC50: 18 nM).
T6879 LLY-507 LLY507,LLY 507 Histone Methyltransferase
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
T13780 MS1943 Apoptosis , Histone Methyltransferase
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
T3257 UNC0638 Influenza Virus , Histone Methyltransferase , Autophagy
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets.
T1841 UNC0379 Histone Methyltransferase
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
T14841 BVT948 Phosphatase , P450 , Histone Methyltransferase
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
T4343 A-196 A 196 Histone Methyltransferase
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.
T4166 UNC0642 UNC-0642,UNC 0642 Histone Methyltransferase
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).
T13954 UNC6852 Histone Methyltransferase , Ligands for Target Protein for PROTAC
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T3458 EED226 Histone Methyltransferase
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
T3099 Pinometostat EPZ-5676 Histone Methyltransferase
Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others.
T36631 BAY-6035 MEK , Histone Methyltransferase
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.
T7194 CM-272 Apoptosis , DNA Methyltransferase , Histone Methyltransferase
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T27133 DCLX069 DCLX 069,DCLX-069 Histone Methyltransferase
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid le...
T40254 MRTX-1719 Histone Methyltransferase
MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.
T2379 UNC1215 Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family.
T7305 JQEZ5 Histone Methyltransferase
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
T12428L PF-06726304 Histone Methyltransferase
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).
T17204 UNC0321 Histone Methyltransferase
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
T2352 AMI-1 Histone Methyltransferase
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).
T7378 BRD9539 Histone Methyltransferase
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
T5605 EZM 2302 GSK3359088 Histone Methyltransferase
EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).
T13279L Valemetostat DS-3201 Histone Methyltransferase
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor.
T21767 MS37452 Others , Histone Methyltransferase
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).
T11486 GSK2807 Trifluoroacetate Histone Methyltransferase
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).
T28996 TP-064 TP 064 Histone Methyltransferase
TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epig...
T6333 MM-102 MM102,HMTase Inhibitor IX Histone Methyltransferase
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM.
T3624 A-366 A 366,A366 Epigenetic Reader Domain , Histone Methyltransferase
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...
T6076 EPZ015666 GSK3235025 Histone Methyltransferase
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity.
T7697 BIX-01294 Histone Methyltransferase , Autophagy
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).

Compounds

Metoprine
T8548
Synonym:
Target: Histone Methyltransferase, Antifolate, Histamine Receptor
Amodiaquine
T8381
Synonym:
Target: Others, Histone Methyltransferase, Parasite
EPZ011989
T2435
Synonym:
Target: Histone Methyltransferase
AZ505
TQ0100
Synonym:
Target: Histone Methyltransferase
EBI-2511
T15194
Synonym:
Target: Histone Methyltransferase
C-7280948
T2097
Synonym: C7280948
Target: Histone Methyltransferase
EPZ005687
T1905
Synonym:
Target: Histone Methyltransferase
MS023
T6900
Synonym:
Target: Histone Methyltransferase
SGC707
T3084
Synonym:
Target: Histone Methyltransferase
SGC2085
T7089
Synonym:
Target: Histone Methyltransferase
BAY-598
T7403
Synonym:
Target: Histone Methyltransferase
GSK503
T1775
Synonym:
Target: Histone Methyltransferase
EPZ004777
T3081
Synonym:
Target: Apoptosis, Histone Methyltransferase
GSK343
T6059
Synonym:
Target: Histone Methyltransferase, Autophagy
JNJ-64619178
T15624
Synonym:
Target: Histone Methyltransferase
UNC1999
T3057
Synonym:
Target: Histone Methyltransferase, Autophagy
UNC3866
T4021
Synonym:
Target: Histone Methyltransferase
MAK683
T15201
Synonym:
Target: Histone Methyltransferase
BCI-121
T5322
Synonym:
Target: Histone Methyltransferase
UNC6934
T9584
Synonym:
Target: Others, Histone Methyltransferase
A-395
T10205
Synonym:
Target: Histone Methyltransferase
LLY-507
T6879
Synonym: LLY507,LLY 507
Target: Histone Methyltransferase
MS1943
T13780
Synonym:
Target: Apoptosis, Histone Methyltransferase
UNC0638
T3257
Synonym:
Target: Influenza Virus, Histone Methyltransferase, Autophagy
UNC0379
T1841
Synonym:
Target: Histone Methyltransferase
BVT948
T14841
Synonym:
Target: Phosphatase, P450, Histone Methyltransferase
A-196
T4343
Synonym: A 196
Target: Histone Methyltransferase
UNC0642
T4166
Synonym: UNC-0642,UNC 0642
Target: Histone Methyltransferase
UNC6852
T13954
Synonym:
Target: Histone Methyltransferase, Ligands for Target Protein for PROTAC
EED226
T3458
Synonym:
Target: Histone Methyltransferase
Pinometostat
T3099
Synonym: EPZ-5676
Target: Histone Methyltransferase
BAY-6035
T36631
Synonym:
Target: MEK, Histone Methyltransferase
CM-272
T7194
Synonym:
Target: Apoptosis, DNA Methyltransferase, Histone Methyltransferase
DCLX069
T27133
Synonym: DCLX 069,DCLX-069
Target: Histone Methyltransferase
MRTX-1719
T40254
Synonym:
Target: Histone Methyltransferase
UNC1215
T2379
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase
JQEZ5
T7305
Synonym:
Target: Histone Methyltransferase
PF-06726304
T12428L
Synonym:
Target: Histone Methyltransferase
UNC0321
T17204
Synonym:
Target: Histone Methyltransferase
AMI-1
T2352
Synonym:
Target: Histone Methyltransferase
BRD9539
T7378
Synonym:
Target: Histone Methyltransferase
EZM 2302
T5605
Synonym: GSK3359088
Target: Histone Methyltransferase
Valemetostat
T13279L
Synonym: DS-3201
Target: Histone Methyltransferase
MS37452
T21767
Synonym:
Target: Others, Histone Methyltransferase
GSK2807 Trifluoroacetate
T11486
Synonym:
Target: Histone Methyltransferase
TP-064
T28996
Synonym: TP 064
Target: Histone Methyltransferase
MM-102
T6333
Synonym: MM102,HMTase Inhibitor IX
Target: Histone Methyltransferase
A-366
T3624
Synonym: A 366,A366
Target: Epigenetic Reader Domain, Histone Methyltransferase
EPZ015666
T6076
Synonym: GSK3235025
Target: Histone Methyltransferase
BIX-01294
T7697
Synonym:
Target: Histone Methyltransferase, Autophagy
1 2 3
Cat No. Product Name Synonyms Targets
T8201 Gambogenic acid Histone Methyltransferase
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
T6803 Chaetocin Histone Methyltransferase , Antibacterial , Antibiotic
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.

Natural Products

Gambogenic acid
T8201
Synonym:
Target: Histone Methyltransferase
Chaetocin
T6803
Synonym:
Target: Histone Methyltransferase, Antibacterial, Antibiotic

Recombinant Proteins

Species：
Human (14)
Expression System：
E. coli (9)
Baculovirus-Insect Cells (3)
HEK293 (1)
Yeast (1)
Tag：
His,GST (3)
N-terminal 6xHis-SUMO-tagged (3)
GST (2)
Tag Free (2)
C-6His (1)
His (1)
His,FLAG (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPY-01708 DOT1L Protein, Human, Recombinant Human E. coli
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil...
TMPH-02105 ASH2L Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 ...
TMPY-01229 SETD7 Protein, Human, Recombinant (His) Human E. coli
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine ...
TMPY-01657 SUV420H2 Protein, Human, Recombinant (His & GST) Human E. coli
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-ly...
TMPH-02227 ERG Protein, Human, Recombinant (His) Human Yeast
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
TMPH-02311 WDR5 Protein, Human, Recombinant (His & SUMO) Human E. coli
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histon...
TMPY-01383 PRMT6 Protein, Human, Recombinant (His & Flag) Human HEK293
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex...
TMPY-01268 SMYD3 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...
TMPY-01265 RIZ1 Protein, Human, Recombinant (GST) Human E. coli
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ...
TMPY-01272 RIZ1 Protein, Human, Recombinant Human E. coli
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ...
TMPH-01712 TRMT112 Protein, Human, Recombinant (His & SUMO) Human E. coli
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylat...
TMPJ-01040 MAX Protein, Human, Recombinant (His) Human E. coli
Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lun...
TMPY-04403 NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPY-02888 MAX Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to the MAX family. It is highly expressed in the brain, heart, and lung while lower levels are seen in the liver, kidney, and skeletal m...
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