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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8548 | Metoprine | Histone Methyltransferase , Antifolate , Histamine Receptor | |
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. | |||
T8381 | Amodiaquine | Others , Histone Methyltransferase , Parasite | |
Amodiaquine is a synthetic aminoquinoline, used to treat malaria. | |||
T2435 | EPZ011989 | Histone Methyltransferase | |
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. | |||
TQ0100 | AZ505 | Histone Methyltransferase | |
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM). | |||
T15194 | EBI-2511 | Histone Methyltransferase | |
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines). | |||
T2097 | C-7280948 | C7280948 | Histone Methyltransferase |
C-7280948 is a PRMT1 inhibitor. | |||
T1905 | EPZ005687 | Histone Methyltransferase | |
EPZ005687 is a potent and selective inhibitor of EZH2. | |||
T6900 | MS023 | Histone Methyltransferase | |
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. | |||
T3084 | SGC707 | Histone Methyltransferase | |
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3. | |||
T7089 | SGC2085 | Histone Methyltransferase | |
SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM). | |||
T7403 | BAY-598 | Histone Methyltransferase | |
BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27 nM. | |||
T1775 | GSK503 | Histone Methyltransferase | |
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity. | |||
T3081 | EPZ004777 | Apoptosis , Histone Methyltransferase | |
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM. | |||
T6059 | GSK343 | Histone Methyltransferase , Autophagy | |
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against other histone methyltransferases. | |||
T15624 | JNJ-64619178 | Histone Methyltransferase | |
JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. | |||
T3057 | UNC1999 | Histone Methyltransferase , Autophagy | |
UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45). | |||
T4021 | UNC3866 | Histone Methyltransferase | |
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen. | |||
T15201 | MAK683 | Histone Methyltransferase | |
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay). | |||
T5322 | BCI-121 | Histone Methyltransferase | |
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell. | |||
T9584 | UNC6934 | Others , Histone Methyltransferase | |
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. | |||
T10205 | A-395 | Histone Methyltransferase | |
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC50: 18 nM). | |||
T6879 | LLY-507 | LLY507,LLY 507 | Histone Methyltransferase |
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2. | |||
T13780 | MS1943 | Apoptosis , Histone Methyltransferase | |
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). | |||
T3257 | UNC0638 | Influenza Virus , Histone Methyltransferase , Autophagy | |
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. | |||
T1841 | UNC0379 | Histone Methyltransferase | |
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. | |||
T14841 | BVT948 | Phosphatase , P450 , Histone Methyltransferase | |
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A). | |||
T4343 | A-196 | A 196 | Histone Methyltransferase |
A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. | |||
T4166 | UNC0642 | UNC-0642,UNC 0642 | Histone Methyltransferase |
UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM). | |||
T13954 | UNC6852 | Histone Methyltransferase , Ligands for Target Protein for PROTAC | |
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC. | |||
T3458 | EED226 | Histone Methyltransferase | |
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM. | |||
T3099 | Pinometostat | EPZ-5676 | Histone Methyltransferase |
Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute Lymphocytic Leukemia, among others. | |||
T36631 | BAY-6035 | MEK , Histone Methyltransferase | |
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases. | |||
T7194 | CM-272 | Apoptosis , DNA Methyltransferase , Histone Methyltransferase | |
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. | |||
T27133 | DCLX069 | DCLX 069,DCLX-069 | Histone Methyltransferase |
DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid le... | |||
T40254 | MRTX-1719 | Histone Methyltransferase | |
MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. | |||
T2379 | UNC1215 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase | |
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family. | |||
T7305 | JQEZ5 | Histone Methyltransferase | |
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). | |||
T12428L | PF-06726304 | Histone Methyltransferase | |
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively). | |||
T17204 | UNC0321 | Histone Methyltransferase | |
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. | |||
T2352 | AMI-1 | Histone Methyltransferase | |
AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1). | |||
T7378 | BRD9539 | Histone Methyltransferase | |
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM | |||
T5605 | EZM 2302 | GSK3359088 | Histone Methyltransferase |
EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM). | |||
T13279L | Valemetostat | DS-3201 | Histone Methyltransferase |
Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor. | |||
T21767 | MS37452 | Others , Histone Methyltransferase | |
MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM). | |||
T11486 | GSK2807 Trifluoroacetate | Histone Methyltransferase | |
GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM). | |||
T28996 | TP-064 | TP 064 | Histone Methyltransferase |
TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epig... | |||
T6333 | MM-102 | MM102,HMTase Inhibitor IX | Histone Methyltransferase |
MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM. | |||
T3624 | A-366 | A 366,A366 | Epigenetic Reader Domain , Histone Methyltransferase |
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... | |||
T6076 | EPZ015666 | GSK3235025 | Histone Methyltransferase |
EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 enzymatic activity. | |||
T7697 | BIX-01294 | Histone Methyltransferase , Autophagy | |
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8201 | Gambogenic acid | Histone Methyltransferase | |
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity. | |||
T6803 | Chaetocin | Histone Methyltransferase , Antibacterial , Antibiotic | |
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01708 | DOT1L Protein, Human, Recombinant | Human | E. coli |
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil... | |||
TMPH-02105 | ASH2L Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 ... | |||
TMPY-01229 | SETD7 Protein, Human, Recombinant (His) | Human | E. coli |
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine ... | |||
TMPY-01657 | SUV420H2 Protein, Human, Recombinant (His & GST) | Human | E. coli |
Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-ly... | |||
TMPH-02227 | ERG Protein, Human, Recombinant (His) | Human | Yeast |
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. | |||
TMPH-02311 | WDR5 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histon... | |||
TMPY-01383 | PRMT6 Protein, Human, Recombinant (His & Flag) | Human | HEK293 |
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex... | |||
TMPY-01268 | SMYD3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger... | |||
TMPY-01265 | RIZ1 Protein, Human, Recombinant (GST) | Human | E. coli |
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ... | |||
TMPY-01272 | RIZ1 Protein, Human, Recombinant | Human | E. coli |
PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a ... | |||
TMPH-01712 | TRMT112 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylat... | |||
TMPJ-01040 | MAX Protein, Human, Recombinant (His) | Human | E. coli |
Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lun... | |||
TMPY-04403 | NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho... | |||
TMPY-02888 | MAX Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to the MAX family. It is highly expressed in the brain, heart, and lung while lower levels are seen in the liver, kidney, and skeletal m... |