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Search Results for " epigenetic-reader-domain "

Targets

110

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T15424 GSK1379725A Epigenetic Reader Domain
GSK1379725A is a selective BPTF ligand (Kd: 2.8 uM). It also shows no binding activity for Brd4.
T11925 M‑89 Epigenetic Reader Domain , Histone Methyltransferase
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to men...
T2072 BET bromodomain inhibitor Epigenetic Reader Domain
BET bromodomain inhibitor is a potent BET inhibitor.
T4495 DBET1 Epigenetic Reader Domain
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.
T5440 Dbet57 Epigenetic Reader Domain
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2
T5130 DBET6 Apoptosis , Epigenetic Reader Domain
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T5362 Y06036 Epigenetic Reader Domain
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM).
T16072 MI-538 Epigenetic Reader Domain , Histone Methyltransferase
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
T1854 MS436 Epigenetic Reader Domain
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
TQ0058 MI-463 Epigenetic Reader Domain , Histone Methyltransferase
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM).
T3311 GSK6853 Epigenetic Reader Domain
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T13363 Y06137 Epigenetic Reader Domain , PKC
Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-resistant prostate cancer.
T3973 PF-CBP1 Epigenetic Reader Domain
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM).
T19935 XD14 Epigenetic Reader Domain
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).
T14685 BMS-986158 Epigenetic Reader Domain
BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively.
T2127 OF-1 Epigenetic Reader Domain
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T6783 BI-7273 Epigenetic Reader Domain
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell.
TQ0253 PLX51107 Epigenetic Reader Domain
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1).
T16321 NI-42 Epigenetic Reader Domain
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele...
TQ0083 NI-57 Epigenetic Reader Domain
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.
T12112 MS402 Epigenetic Reader Domain
MS402 is a novel BD1-selective BET BrD inhibitor.
TQ0069 MI-503 Epigenetic Reader Domain , Histone Methyltransferase
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction.
T9749 FHD-286 Epigenetic Reader Domain
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia.
T17697 BRD7-IN-1 Epigenetic Reader Domain
BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC 50 s of 4.5 and 1.8 nM, respectively) [1].
T11136 E-7386 E7386 Epigenetic Reader Domain
E-7386 is an oral active CBP/ -catenin modulator.
T5435 ARV-771 Epigenetic Reader Domain
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1].
T5442 A1874 Epigenetic Reader Domain , PROTACs
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
T5417 INCB-057643 Apoptosis , Epigenetic Reader Domain
INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
T17311 (+)-JQ1 PA Epigenetic Reader Domain
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T9568 SGC-SMARCA-BRDVIII Epigenetic Reader Domain
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.
T5434 ARV-825 Epigenetic Reader Domain
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
T6939 PFI-3 PFI 3 Epigenetic Reader Domain
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
T3624 A-366 A 366,A366 Epigenetic Reader Domain , Histone Methyltransferase
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...
T9703 GSK778 Epigenetic Reader Domain
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ...
T6786 BI-9564 BI 9564,BI9564 Epigenetic Reader Domain
BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM.
T6026 CPI-203 CPI 203,CPI203 Apoptosis , Epigenetic Reader Domain
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T15405 GNE-781 Epigenetic Reader Domain
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
T14073 A-485 Epigenetic Reader Domain , Histone Acetyltransferase
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively).
T17350 ACBI1 Apoptosis , Epigenetic Reader Domain , PROTACs
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ...
T15216 EML 425 Epigenetic Reader Domain , Histone Acetyltransferase
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T5318 666-15 CREB inhibitor Epigenetic Reader Domain
666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM).
T9194 UMB298 Epigenetic Reader Domain
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
T8890 653-47 hydrochloride Epigenetic Reader Domain
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
T7264 CBP/EP300-IN-1 Epigenetic Reader Domain
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor.
T4345 CeMMEC1 CeMMEC1 HCl Epigenetic Reader Domain , Carboxypeptidase , DNA/RNA Synthesis
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
T14776 BRD4 Inhibitor-10 Epigenetic Reader Domain
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T9629 BRD4 Inhibitor-24 Epigenetic Reader Domain
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.
T6811 CPI-637 CPI 637 Epigenetic Reader Domain , Histone Acetyltransferase
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor.
T2452 C646 Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase , Autophagy
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T1972 GSK-5959 Epigenetic Reader Domain
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family...

Compounds

GSK1379725A
T15424
Synonym:
Target: Epigenetic Reader Domain
M‑89
T11925
Synonym:
Target: Epigenetic Reader Domain, Histone Methyltransferase
BET bromodomain inhibitor
T2072
Synonym:
Target: Epigenetic Reader Domain
dBET1
T4495
Synonym:
Target: Epigenetic Reader Domain
Dbet57
T5440
Synonym:
Target: Epigenetic Reader Domain
dBET6
T5130
Synonym:
Target: Apoptosis, Epigenetic Reader Domain
Y06036
T5362
Synonym:
Target: Epigenetic Reader Domain
MI-538
T16072
Synonym:
Target: Epigenetic Reader Domain, Histone Methyltransferase
MS436
T1854
Synonym:
Target: Epigenetic Reader Domain
MI-463
TQ0058
Synonym:
Target: Epigenetic Reader Domain, Histone Methyltransferase
GSK6853
T3311
Synonym:
Target: Epigenetic Reader Domain
Y06137
T13363
Synonym:
Target: Epigenetic Reader Domain, PKC
PF-CBP1
T3973
Synonym:
Target: Epigenetic Reader Domain
XD14
T19935
Synonym:
Target: Epigenetic Reader Domain
BMS-986158
T14685
Synonym:
Target: Epigenetic Reader Domain
OF-1
T2127
Synonym:
Target: Epigenetic Reader Domain
BI-7273
T6783
Synonym:
Target: Epigenetic Reader Domain
PLX51107
TQ0253
Synonym:
Target: Epigenetic Reader Domain
NI-42
T16321
Synonym:
Target: Epigenetic Reader Domain
NI-57
TQ0083
Synonym:
Target: Epigenetic Reader Domain
MS402
T12112
Synonym:
Target: Epigenetic Reader Domain
MI-503
TQ0069
Synonym:
Target: Epigenetic Reader Domain, Histone Methyltransferase
FHD-286
T9749
Synonym:
Target: Epigenetic Reader Domain
BRD7-IN-1
T17697
Synonym:
Target: Epigenetic Reader Domain
E-7386
T11136
Synonym: E7386
Target: Epigenetic Reader Domain
ARV-771
T5435
Synonym:
Target: Epigenetic Reader Domain
A1874
T5442
Synonym:
Target: Epigenetic Reader Domain, PROTACs
INCB-057643
T5417
Synonym:
Target: Apoptosis, Epigenetic Reader Domain
(+)-JQ1 PA
T17311
Synonym:
Target: Epigenetic Reader Domain
SGC-SMARCA-BRDVIII
T9568
Synonym:
Target: Epigenetic Reader Domain
ARV-825
T5434
Synonym:
Target: Epigenetic Reader Domain
PFI-3
T6939
Synonym: PFI 3
Target: Epigenetic Reader Domain
A-366
T3624
Synonym: A 366,A366
Target: Epigenetic Reader Domain, Histone Methyltransferase
GSK778
T9703
Synonym:
Target: Epigenetic Reader Domain
BI-9564
T6786
Synonym: BI 9564,BI9564
Target: Epigenetic Reader Domain
CPI-203
T6026
Synonym: CPI 203,CPI203
Target: Apoptosis, Epigenetic Reader Domain
GNE-781
T15405
Synonym:
Target: Epigenetic Reader Domain
A-485
T14073
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
ACBI1
T17350
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, PROTACs
EML 425
T15216
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase
666-15
T5318
Synonym: CREB inhibitor
Target: Epigenetic Reader Domain
UMB298
T9194
Synonym:
Target: Epigenetic Reader Domain
653-47 hydrochloride
T8890
Synonym:
Target: Epigenetic Reader Domain
CBP/EP300-IN-1
T7264
Synonym:
Target: Epigenetic Reader Domain
CeMMEC1
T4345
Synonym: CeMMEC1 HCl
Target: Epigenetic Reader Domain, Carboxypeptidase, DNA/RNA Synthesis
BRD4 Inhibitor-10
T14776
Synonym:
Target: Epigenetic Reader Domain
BRD4 Inhibitor-24
T9629
Synonym:
Target: Epigenetic Reader Domain
CPI-637
T6811
Synonym: CPI 637
Target: Epigenetic Reader Domain, Histone Acetyltransferase
C646
T2452
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase, Autophagy
GSK-5959
T1972
Synonym:
Target: Epigenetic Reader Domain
1 2 3
Cat No. Product Name Synonyms Targets
T6389 Anacardic Acid 6-pentadecylsalicylic Acid,Hydroginkgolic acid Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...
T1516 Curcumin Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00694 BRD4 Protein, Human, Recombinant (His & Flag) Human E. coli
Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remain...
TargetMol