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Cat No. | Product Name | Synonyms | Targets |
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T15424 | GSK1379725A | Epigenetic Reader Domain | |
GSK1379725A is a selective BPTF ligand (Kd: 2.8 uM). It also shows no binding activity for Brd4. | |||
T11925 | M‑89 | Epigenetic Reader Domain , Histone Methyltransferase | |
M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia. M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to men... | |||
T2072 | BET bromodomain inhibitor | Epigenetic Reader Domain | |
BET bromodomain inhibitor is a potent BET inhibitor. | |||
T4495 | DBET1 | Epigenetic Reader Domain | |
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis. | |||
T5440 | Dbet57 | Epigenetic Reader Domain | |
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2 | |||
T5130 | DBET6 | Apoptosis , Epigenetic Reader Domain | |
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity. | |||
T5362 | Y06036 | Epigenetic Reader Domain | |
Y06036, a potent and selective BET inhibitor, can bind to the BRD4(1) bromodomain (Kd: 82 nM). | |||
T16072 | MI-538 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). | |||
T1854 | MS436 | Epigenetic Reader Domain | |
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains. | |||
TQ0058 | MI-463 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-463 is a potent and orally bioavailable inhibitor of the menin-mLL interaction (IC50: 15.3 nM). | |||
T3311 | GSK6853 | Epigenetic Reader Domain | |
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain. | |||
T13363 | Y06137 | Epigenetic Reader Domain , PKC | |
Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-resistant prostate cancer. | |||
T3973 | PF-CBP1 | Epigenetic Reader Domain | |
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM). | |||
T19935 | XD14 | Epigenetic Reader Domain | |
XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively). | |||
T14685 | BMS-986158 | Epigenetic Reader Domain | |
BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively. | |||
T2127 | OF-1 | Epigenetic Reader Domain | |
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain. | |||
T6783 | BI-7273 | Epigenetic Reader Domain | |
BI-7273 is an effective, specific, BRD9 BD Inhibitor, which can infiltrate cell. | |||
TQ0253 | PLX51107 | Epigenetic Reader Domain | |
PLX51107 is a potent and selective BET inhibitor (Kds: 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1). | |||
T16321 | NI-42 | Epigenetic Reader Domain | |
NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent sele... | |||
TQ0083 | NI-57 | Epigenetic Reader Domain | |
NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively. | |||
T12112 | MS402 | Epigenetic Reader Domain | |
MS402 is a novel BD1-selective BET BrD inhibitor. | |||
TQ0069 | MI-503 | Epigenetic Reader Domain , Histone Methyltransferase | |
MI-503 is a highly effective and orally bioavailable inhibitor of the menin-mLL interaction. | |||
T9749 | FHD-286 | Epigenetic Reader Domain | |
FHD-286 is an inhibitor of BRM/BRG1 ATPase and can be used for studies on the treatment of BAF-related disorders such as acute myeloid leukemia. | |||
T17697 | BRD7-IN-1 | Epigenetic Reader Domain | |
BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC 50 s of 4.5 and 1.8 nM, respectively) [1]. | |||
T11136 | E-7386 | E7386 | Epigenetic Reader Domain |
E-7386 is an oral active CBP/ -catenin modulator. | |||
T5435 | ARV-771 | Epigenetic Reader Domain | |
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively[1]. | |||
T5442 | A1874 | Epigenetic Reader Domain , PROTACs | |
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation. | |||
T5417 | INCB-057643 | Apoptosis , Epigenetic Reader Domain | |
INCB057643 is a potent, selective and orally bioavailable BET inhibitor. | |||
T17311 | (+)-JQ1 PA | Epigenetic Reader Domain | |
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM). | |||
T9568 | SGC-SMARCA-BRDVIII | Epigenetic Reader Domain | |
SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively. | |||
T5434 | ARV-825 | Epigenetic Reader Domain | |
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. | |||
T6939 | PFI-3 | PFI 3 | Epigenetic Reader Domain |
PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer. | |||
T3624 | A-366 | A 366,A366 | Epigenetic Reader Domain , Histone Methyltransferase |
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met... | |||
T9703 | GSK778 | Epigenetic Reader Domain | |
GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ... | |||
T6786 | BI-9564 | BI 9564,BI9564 | Epigenetic Reader Domain |
BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM. | |||
T6026 | CPI-203 | CPI 203,CPI203 | Apoptosis , Epigenetic Reader Domain |
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4). | |||
T15405 | GNE-781 | Epigenetic Reader Domain | |
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively). | |||
T14073 | A-485 | Epigenetic Reader Domain , Histone Acetyltransferase | |
A-485 is a potent and selective catalytic p300/CBP inhibitor(IC50s of 9.8 nM and 2.6 nM for p300 and CBP, respectively). | |||
T17350 | ACBI1 | Apoptosis , Epigenetic Reader Domain , PROTACs | |
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ... | |||
T15216 | EML 425 | Epigenetic Reader Domain , Histone Acetyltransferase | |
EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively). | |||
T5318 | 666-15 | CREB inhibitor | Epigenetic Reader Domain |
666-15 (CREB inhibitor) is a potent and selective CREB inhibitor (IC50: 81 nM). | |||
T9194 | UMB298 | Epigenetic Reader Domain | |
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM. | |||
T8890 | 653-47 hydrochloride | Epigenetic Reader Domain | |
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM. | |||
T7264 | CBP/EP300-IN-1 | Epigenetic Reader Domain | |
CBP/EP300-IN-1 is a CBP/EP300 bromodomain inhibitor. | |||
T4345 | CeMMEC1 | CeMMEC1 HCl | Epigenetic Reader Domain , Carboxypeptidase , DNA/RNA Synthesis |
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM). | |||
T14776 | BRD4 Inhibitor-10 | Epigenetic Reader Domain | |
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM). | |||
T9629 | BRD4 Inhibitor-24 | Epigenetic Reader Domain | |
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity. | |||
T6811 | CPI-637 | CPI 637 | Epigenetic Reader Domain , Histone Acetyltransferase |
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor. | |||
T2452 | C646 | Apoptosis , Epigenetic Reader Domain , Histone Acetyltransferase , Autophagy | |
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay). | |||
T1972 | GSK-5959 | Epigenetic Reader Domain | |
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family... |
Cat No. | Product Name | Synonyms | Targets |
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T6389 | Anacardic Acid | 6-pentadecylsalicylic Acid,Hydroginkgolic acid | Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial |
Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland... | |||
T1516 | Curcumin | Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow | Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy |
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00694 | BRD4 Protein, Human, Recombinant (His & Flag) | Human | E. coli |
Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remain... |