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Search Results for " crosslinker "

Targets

83

Compounds

2

Natural Products

Cat No. Product Name Synonyms Targets
T15179 DTSSP Crosslinker Others
DTSSP Crosslinker is a cleavable ADC linker and can be used to synthesize antibody-drug conjugates (ADCs).
T15175 DSP Crosslinker Others
DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1].
T15176 DSS Crosslinker Others
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters a...
T15171 DSG Crosslinker Others
DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T14833L BS3 Crosslinker disodium Others
BS3 Crosslinker disodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T34746 Sulfo-SANPAH Crosslinker Sulfo-SANPAH Cross-linker,Sulfo-SANPAH Cross linker Others
Sulfo-SANPAH Crosslinker (Sulfo-SANPAH Cross linker) is a water-soluble isobisfunctional protein crosslinker.
T15203 EGNHS EGS crosslinker Others
EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
T19941 MBS Crosslinker MBS protein crosslinker
MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add su...
T6741 SPDP SPDP Crosslinker Others
SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could ...
T30599 BS3-d4 Deuterated Crosslinker Deuterated Crosslinker BS3-d4,BS3-d4,D4-BS3
BS3-d4 Deuterated Crosslinker or Bis(Sulfosuccinimidyl) 2,2,7,7-suberate-d4, is a water-soluble and membrane impermeable protein crosslinking agent.
T16880 SIA Crosslinker Others
SIA Crosslinker is a non-cleavable ADC linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].
T14833 BS3 Crosslinker Others
BS3 Crosslinker is a non-cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1]. It is utilized specifically for its proficiency in connecting antibodies with drugs, enhancing the overall effici...
T16903 SMPH Crosslinker Others
SMPH Crosslinker is an alkyl/ether-based PROTAC linker utilized for synthesizing PROTACs[1].
T34742 Sulfo-EGS Crosslinker
Sulfo-egs crosslinker or ethylene glycol bis (sulfosuccinimide succinate) is a water-soluble isofunctional crosslinker that is not permeable to cell membranes and can be used to label cell surface proteins.
T19947 EDC hydrochloride EDC-HCl Crosslinker,1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Others
EDC hydrochloride (EDC-HCl Crosslinker) is a zero-length crosslinker. EDC hydrochloride is ideal for covalently binding proteins or peptides to carboxyl containing beads, resins, or other nanoparticals.
T14832 BS2G Crosslinker disodium Others
BS2G Crosslinker (disodium) is a non-cleavable linker employed for synthesizing antibody-drug conjugates (ADCs)[1].
T19946 DCC Crosslinker DCC Cross-linker,Cyclohexaamine
DCC Crosslinker is a zero-length crosslinker. DCC crosslinker is commonly used in the synthesis of active ester-containing reagents.
T18864 UAA crosslinker 1 Others
UAA crosslinker 1 hydrochloride is an Amber codon-activating agent utilized for the incorporation of non-canonical amino acids (ncAAs) into proteins. This incorporation is achieved in vivo by leveraging the promiscuous a...
T30597 BS2G Crosslinker BS2G Cross linker,BS2G Cross-linker
BS2G crosslinker (Bis[Sulfosuccinimidyl] glutarate) is an amine reactive, water-soluble, isofunctional protein crosslinker. The molecule is impenetrable to cell membranes and can be used to label cell surface proteins.
T31584 DST Crosslinker DST Cross linker,DST Cross-linker
DST crosslinker(disuccinimide tartarate) is an isotype bifunctional, cleavable crosslinker (cleavable by an oxidizer) for applications that require crosslinking cleavability and that do not interfere with protein disulfi...
T19944 DSSeb Crosslinker DSSeb Cross linker,DSSeb Cross-linker
DSSeb Crosslinker is a homobifunctional cross-linking reagent. It is useful in protein crosslinking and making antibody-drug conjugates.
T19943 SMPB Crosslinker SMPB Cross linker,SMPB Cross-linker
SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslin...
T19942 SBA Crosslinker SBA Cross-linker,SBA Cross linker
SBA crosslinker is a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. SBA protein crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents k...
T31583 DSS-d4 Deuterated Crosslinker
DSS-d4 Deuterated Crosslinker, or Bis[Succinimidyl] 2,2,7,7-suberate-d4 is a membrane permeable crosslinker with four deuterium atoms.
T31581 DSG-d4 Deuterated Crosslinker
DSG-d4 Deuterated Crosslinker, or Bis[Succinimidyl] 2,2,4,4-glutarate-d4 is a protein crosslinker that is permeable to cell membranes.
T33904 PDPH Crosslinker PDPH Cross linker,SPDP Hydrazide,PDPH Cross-linker
PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.
T24842 Sulfo-SIA Crosslinker Sulfo-SIA Cross-linker,Sulfo-SIA Cross linker
Sulfo-SIA Crosslinker is a non-cleavable, heterobifunctional protein crosslinker. Sulfo-SIA Crosslinker is useful in making antibody-drug conjugates.
T24841 Sulfo-MBS Crosslinker Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker
Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies.
T18863 UAA crosslinker 1 hydrochloride Others
UAA crosslinker 1 hydrochloride is an amber codon used to incorporate non-canonical amino acids (ncAAs) into proteins in vivo. This is achieved by leveraging the promiscuous activity of specific wildtype and engineered a...
T30598 BS2G-d4 Deuterated Crosslinker D4-BS2G,BS2G-d4
BS2G-d4 or Bis(Sulfosuccinimidyl) 2,2,4,4-glutarate-d4, is a water-soluble and membrane impermeable protein crosslinking agent.
T74339 DNA crosslinker 3 dihydrochloride
DNA Crosslinker 3 (dihydrochloride) (Compound 1) is a potent minor groove binder, exhibiting a DNA binding affinity (ΔTm) of 1.4°C, and serves as a valuable tool in anticancer research [1].
T74337 DNA crosslinker 1 dihydrochloride
DNA Crosslinker 1 (dihydrochloride) serves as a potent binder for the DNA minor groove, exhibiting a DNA binding affinity (ΔTm) of 1.1°C. This compound is utilized in research focused on anticancer therapies [1].
T74340 DNA crosslinker 4 dihydrochloride
DNA Crosslinker 4 (dihydrochloride) is a potent binder of the DNA minor groove with inhibitory effects on cancer cell lines NCI-H460, A2780, and MCF-7. It is utilized in research for anticancer applications [1].
T74338 DNA crosslinker 2 dihydrochloride
DNA crosslinker 2 (dihydrochloride) is a potent minor groove binder exhibiting a Δ T m of 1.2 °C, indicative of its DNA binding affinity. This compound demonstrates inhibitory activity against cancer cell lines NCI-H460,...
T18865 Azide-phenylalanine hydrochloride UAA crosslinker 2 Others
UAA crosslinker 2 is a phenylalanine derivative.
T0707L Cyclophosphamide DNA Alkylator/Crosslinker , DNA , MRP
Cyclophosphamide is an alkylating agent used in the treatment of several forms of cancer including leukemias, lymphomas and breast cancer.
T19945 N,N'-Carbonyldiimidazole 1,1'-Carbonyldiimidazole,N,N'-Carbonyldiimidazole,CDI Crosslinker Others
N,N'-Carbonyldiimidazole is a biological cross-linking agent that has great application in mass spectrometry to detect the purity of compounds.
T4368 Miriplatin SM-11355 DNA Alkylator/Crosslinker
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC).
T0923 Busulfan Myleran,Sulphabutin,Busulphan Apoptosis , DNA Alkylator/Crosslinker , DNA Alkylation
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation...
T1564 Cisplatin cis-Diaminodichloroplatinum,CDDP DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy.
T1055 Ifosfamide NSC109724,Isophosphamide DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the nitrogen mustard cyclophosphamide with antineoplastic acti...
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T8554 KCC-07 DNA Alkylator/Crosslinker
KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenes...
T17159 Treosulfan NSC 39069,Treosulphan DNA Alkylator/Crosslinker , DNA Alkylation
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T15793 Lurbinectedin PM01183 Others
Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.
T0164 Oxaliplatin L-OHP DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin induces autop...
T5017 Nimustine Hydrochloride Nidran hydrochloride Apoptosis , Others , DNA Alkylator/Crosslinker , DNA/RNA Synthesis
Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T1058 Carboplatin NSC 241240,CBDCA,JM-8 DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death. Carboplatin has antitumor activity.
T8380 Bendamustine SDX105 Apoptosis , Others , DNA Alkylator/Crosslinker
Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T1601 Lomustine CCNU,NSC 79037 Apoptosis , Others , DNA Alkylator/Crosslinker , DNA Alkylation , Autophagy
Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.

Compounds

DTSSP Crosslinker
T15179
Synonym:
Target: Others
DSP Crosslinker
T15175
Synonym:
Target: Others
DSS Crosslinker
T15176
Synonym:
Target: Others
DSG Crosslinker
T15171
Synonym:
Target: Others
BS3 Crosslinker disodium
T14833L
Synonym:
Target: Others
Sulfo-SANPAH Crosslinker
T34746
Synonym: Sulfo-SANPAH Cross-linker,Sulfo-SANPAH Cross linker
Target: Others
EGNHS
T15203
Synonym: EGS crosslinker
Target: Others
MBS Crosslinker
T19941
Synonym: MBS protein crosslinker
Target:
SPDP
T6741
Synonym: SPDP Crosslinker
Target: Others
BS3-d4 Deuterated Crosslinker
T30599
Synonym: Deuterated Crosslinker BS3-d4,BS3-d4,D4-BS3
Target:
SIA Crosslinker
T16880
Synonym:
Target: Others
BS3 Crosslinker
T14833
Synonym:
Target: Others
SMPH Crosslinker
T16903
Synonym:
Target: Others
Sulfo-EGS Crosslinker
T34742
Synonym:
Target:
EDC hydrochloride
T19947
Synonym: EDC-HCl Crosslinker,1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Target: Others
BS2G Crosslinker disodium
T14832
Synonym:
Target: Others
DCC Crosslinker
T19946
Synonym: DCC Cross-linker,Cyclohexaamine
Target:
UAA crosslinker 1
T18864
Synonym:
Target: Others
BS2G Crosslinker
T30597
Synonym: BS2G Cross linker,BS2G Cross-linker
Target:
DST Crosslinker
T31584
Synonym: DST Cross linker,DST Cross-linker
Target:
DSSeb Crosslinker
T19944
Synonym: DSSeb Cross linker,DSSeb Cross-linker
Target:
SMPB Crosslinker
T19943
Synonym: SMPB Cross linker,SMPB Cross-linker
Target:
SBA Crosslinker
T19942
Synonym: SBA Cross-linker,SBA Cross linker
Target:
DSS-d4 Deuterated Crosslinker
T31583
Synonym:
Target:
DSG-d4 Deuterated Crosslinker
T31581
Synonym:
Target:
PDPH Crosslinker
T33904
Synonym: PDPH Cross linker,SPDP Hydrazide,PDPH Cross-linker
Target:
Sulfo-SIA Crosslinker
T24842
Synonym: Sulfo-SIA Cross-linker,Sulfo-SIA Cross linker
Target:
Sulfo-MBS Crosslinker
T24841
Synonym: Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker
Target:
UAA crosslinker 1 hydrochloride
T18863
Synonym:
Target: Others
BS2G-d4 Deuterated Crosslinker
T30598
Synonym: D4-BS2G,BS2G-d4
Target:
DNA crosslinker 3 dihydrochloride
T74339
Synonym:
Target:
DNA crosslinker 1 dihydrochloride
T74337
Synonym:
Target:
DNA crosslinker 4 dihydrochloride
T74340
Synonym:
Target:
DNA crosslinker 2 dihydrochloride
T74338
Synonym:
Target:
Azide-phenylalanine hydrochloride
T18865
Synonym: UAA crosslinker 2
Target: Others
Cyclophosphamide
T0707L
Synonym:
Target: DNA Alkylator/Crosslinker, DNA, MRP
N,N'-Carbonyldiimidazole
T19945
Synonym: 1,1'-Carbonyldiimidazole,N,N'-Carbonyldiimidazole,CDI Crosslinker
Target: Others
Miriplatin
T4368
Synonym: SM-11355
Target: DNA Alkylator/Crosslinker
Busulfan
T0923
Synonym: Myleran,Sulphabutin,Busulphan
Target: Apoptosis, DNA Alkylator/Crosslinker, DNA Alkylation
Cisplatin
T1564
Synonym: cis-Diaminodichloroplatinum,CDDP
Target: DNA Alkylator/Crosslinker, Ferroptosis, DNA/RNA Synthesis, Autophagy
Ifosfamide
T1055
Synonym: NSC109724,Isophosphamide
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Duocarmycin TM
T11120
Synonym:
Target: DNA Alkylation, Antibiotic
KCC-07
T8554
Synonym:
Target: DNA Alkylator/Crosslinker
Treosulfan
T17159
Synonym: NSC 39069,Treosulphan
Target: DNA Alkylator/Crosslinker, DNA Alkylation
Lurbinectedin
T15793
Synonym: PM01183
Target: Others
Oxaliplatin
T0164
Synonym: L-OHP
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Nimustine Hydrochloride
T5017
Synonym: Nidran hydrochloride
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA/RNA Synthesis
Carboplatin
T1058
Synonym: NSC 241240,CBDCA,JM-8
Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy
Bendamustine
T8380
Synonym: SDX105
Target: Apoptosis, Others, DNA Alkylator/Crosslinker
Lomustine
T1601
Synonym: CCNU,NSC 79037
Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy
1 2
Cat No. Product Name Synonyms Targets
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...
T1507 Streptozocin STZ,Streptozotocin,NSC-85998,U 9889 DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th...
TargetMol