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Search Results for " bcr-abl "

Targets

107

Compounds

1

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T72958 BCR-ABL-IN-7 Bcr-Abl
BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.
T39732 BCR-ABL-IN-3
BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer acti...
T10489 BCR-ABL-IN-2 Others
BCR-ABL-IN-2 is a BCR-ABL1 tyrosine kinase inhibitor (IC50s: 57 nM, 773 nM for ABL1 native and ABL1 T315I).
T10488 BCR-ABL-IN-1 Bcr-Abl
BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
T5177 Asciminib ABL001 Bcr-Abl
Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).
T21785 AG957 Bcr-Abl
Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].
T3071 Olverembatinib GZD 824 Bcr-Abl
Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).
T8488 GMB-475 Bcr-Abl
GMB-475 is a BCR-ABL1 tyrosine kinase degrader based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL).resulting in ubiquitinati...
T8882 Vodobatinib K-0706 Bcr-Abl
Vodobatinib (K-0706) is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity.
T17267 XL228 IGF-1R , Bcr-Abl , Src , Aurora Kinase
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T2429 Olverembatinib dimesylate GZD824 Dimesylate,HQP1351 Bcr-Abl
Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).
T0152 Bosutinib SKI-606 Bcr-Abl , Src , Autophagy
Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.
T3063 PD173955 PD-173955,PD 173955 Apoptosis , Bcr-Abl , Src
PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR and PKC.
T6300 Degrasyn WP1130 Apoptosis , JAK , Bcr-Abl , DUB , Autophagy
Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (without affecting 20S proteasome) and activator of transcri...
T63332 BCR-ABL-IN-5
BCR-ABL-IN-5 is a Bcr-Abl (Breakpoint cluster region-Abelson) kinase inhibitor that acts on Bcr-AblWT (IC50: 0.014 μM) and Bcr-AblT3151 (IC50: 0.45 μM) and exhibits some anti-proliferative effects on leukemic cells. effe...
T11916 Lyn-IN-1 Bafetinib analog Bcr-Abl , Src
Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and Lyn
T1803 GNF-5 GNF 5 SARS-CoV , Bcr-Abl
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.
T82909 BCR-ABL-IN-8 Bcr-Abl
BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].
T63450 BCR-ABL-IN-6
BCR-ABL-IN-6 (9h) is an imatinib derivative and a selective inhibitor of Bcr-Abl kinase that acts on Bcr-AblWT (IC50: 4.6 nM) and Bcr-AblT3151 (IC50: 277 nM). BCR-ABL-IN-6 (9h) was able to be used in the study of chronic...
T63932 BCR-ABL-IN-4
BCR-ABL-IN-4 is a BCR-ABLL inhibitor that exhibits anticancer activity.BCR-ABL-IN-4 has an inhibitory effect on cancer cell growth and is able to act on K562 cells (IC50: 0.67 nM) and BCR-ABL T315I-transfected Ba/F3 cell...
T4320 Flumatinib HHGV678 Bcr-Abl , PDGFR , c-Kit
Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
T77974 PROTAC BCR-ABL Degrader-1 PROTACs
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway and demonstrates antiproliferative effects on K562 cells, suggesting its...
T3196 GNF-7 GNF7 Bcr-Abl , ACK , AChR
GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
T22553 Adaphostin 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410 Bcr-Abl
Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
T11898 LXH254 Raf
LXH254 is a potent C-Raf and B-Raf inhibitor.
T2802 Nocodazole R17934,Oncodazole Apoptosis , Microtubule Associated , Bcr-Abl , Autophagy , CRISPR/Cas9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
T1524 Nilotinib Tasigna,AMN107 Bcr-Abl , Autophagy
Nilotinib (AMN107) is a second-generation Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
T2640 Rebastinib DCC2036,DCC 2036,DCC-2036 Apoptosis , FLT , Bcr-Abl , Src
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...
T2341 KW-2449 KW2449 Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T1448 Dasatinib BMS-354825 Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly...
T1817 GNF-2 GNF2 SARS-CoV , Bcr-Abl
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.
T2372 Ponatinib AP24534 VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).
T7861 Flumatinib mesylate HHGV678 mesylate Bcr-Abl , PDGFR , c-Kit
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
T16545 Pivanex Pivalyloxymethyl butyrate,AN-9 Apoptosis , HDAC , Bcr-Abl
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.
T6311 Bafetinib NS-187,INNO-406 Bcr-Abl , Src , Autophagy
Bafetinib (INNO-406) (INNO-406) is an effective and specific dual Bcr-Abl/Lyn inhibitor (IC50: 5.8/19 nM), and no inhibition of the phosphorylation of the T315I mutant and less effective to c-Kit and PDGFR.
T4191 Multi-kinase inhibitor 1 Multi-kinase inhibitor I Others , Bcr-Abl , PDGFR , c-Kit
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.
T3068 AT9283 J-504568 Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
T13832 PROTAC BCR-ABL1 ligand 1 Others
PROTAC BCR-ABL1 ligand 1 is the ligand of PROTAC .
T14871 Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate Calcium Channel
Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the o...
T6230 Imatinib STI571,CGP057148B,ST-1571 SARS-CoV , Bcr-Abl , PDGFR , c-Kit , Autophagy
Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with oral activity. Imatinib has antitumor activity for the tre...
T4053 AST 487 NVP-AST 487 VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
T1448L Dasatinib monohydrate BMS-354825 Monohydrate Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T2147 Nilotinib monohydrochloride monohydrate Nilotinib (monohydrochloride monohydrate),AMN107 (monohydrochloride monohydrate) Bcr-Abl , Autophagy
Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL muta...
T1621 Imatinib Mesylate ST-1571 Mesylate,STI-571,CGP-57148B Bcr-Abl , PDGFR , c-Kit , Autophagy
Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, respectively).
T2693 AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200 Apoptosis , IGF-1R
AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
T4618 BGG463 K 0859 Bcr-Abl , CDK
BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
T22378 Nilotinib hydrochloride AMN-107 HCl Bcr-Abl , Autophagy
Nilotinib hydrochloride(AMN-107 HCl) is an orally available Bcr-Abl tyrosine kinase inhibitor with antitumor activity for modulation of neuroinflammation and cognitive deficits, and may be used in studies of chronic myel...
T10799 CHMFL-ABL-039 Bcr-Abl
CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor (IC50s: 7.9 nM and 27.9 nM) used in the research of chronic myeloid leukemia.
T63746 Vamotinib PF-114 Apoptosis , Tyrosine Kinases , Bcr-Abl
Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. ...
T23128 PD180970 PD 180970 Bcr-Abl , Src , c-Kit
PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia.

Compounds

BCR-ABL-IN-7
T72958
Synonym:
Target: Bcr-Abl
BCR-ABL-IN-3
T39732
Synonym:
Target:
BCR-ABL-IN-2
T10489
Synonym:
Target: Others
BCR-ABL-IN-1
T10488
Synonym:
Target: Bcr-Abl
Asciminib
T5177
Synonym: ABL001
Target: Bcr-Abl
AG957
T21785
Synonym:
Target: Bcr-Abl
Olverembatinib
T3071
Synonym: GZD 824
Target: Bcr-Abl
GMB-475
T8488
Synonym:
Target: Bcr-Abl
Vodobatinib
T8882
Synonym: K-0706
Target: Bcr-Abl
XL228
T17267
Synonym:
Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase
Olverembatinib dimesylate
T2429
Synonym: GZD824 Dimesylate,HQP1351
Target: Bcr-Abl
Bosutinib
T0152
Synonym: SKI-606
Target: Bcr-Abl, Src, Autophagy
PD173955
T3063
Synonym: PD-173955,PD 173955
Target: Apoptosis, Bcr-Abl, Src
Degrasyn
T6300
Synonym: WP1130
Target: Apoptosis, JAK, Bcr-Abl, DUB, Autophagy
BCR-ABL-IN-5
T63332
Synonym:
Target:
Lyn-IN-1
T11916
Synonym: Bafetinib analog
Target: Bcr-Abl, Src
GNF-5
T1803
Synonym: GNF 5
Target: SARS-CoV, Bcr-Abl
BCR-ABL-IN-8
T82909
Synonym:
Target: Bcr-Abl
BCR-ABL-IN-6
T63450
Synonym:
Target:
BCR-ABL-IN-4
T63932
Synonym:
Target:
Flumatinib
T4320
Synonym: HHGV678
Target: Bcr-Abl, PDGFR, c-Kit
PROTAC BCR-ABL Degrader-1
T77974
Synonym:
Target: PROTACs
GNF-7
T3196
Synonym: GNF7
Target: Bcr-Abl, ACK, AChR
Adaphostin
T22553
Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410
Target: Bcr-Abl
LXH254
T11898
Synonym:
Target: Raf
Nocodazole
T2802
Synonym: R17934,Oncodazole
Target: Apoptosis, Microtubule Associated, Bcr-Abl, Autophagy, CRISPR/Cas9
Nilotinib
T1524
Synonym: Tasigna,AMN107
Target: Bcr-Abl, Autophagy
Rebastinib
T2640
Synonym: DCC2036,DCC 2036,DCC-2036
Target: Apoptosis, FLT, Bcr-Abl, Src
KW-2449
T2341
Synonym: KW2449
Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase
Dasatinib
T1448
Synonym: BMS-354825
Target: Apoptosis, Bcr-Abl, Src, c-Kit, Autophagy
GNF-2
T1817
Synonym: GNF2
Target: SARS-CoV, Bcr-Abl
Ponatinib
T2372
Synonym: AP24534
Target: VEGFR, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Autophagy
Flumatinib mesylate
T7861
Synonym: HHGV678 mesylate
Target: Bcr-Abl, PDGFR, c-Kit
Pivanex
T16545
Synonym: Pivalyloxymethyl butyrate,AN-9
Target: Apoptosis, HDAC, Bcr-Abl
Bafetinib
T6311
Synonym: NS-187,INNO-406
Target: Bcr-Abl, Src, Autophagy
Multi-kinase inhibitor 1
T4191
Synonym: Multi-kinase inhibitor I
Target: Others, Bcr-Abl, PDGFR, c-Kit
AT9283
T3068
Synonym: J-504568
Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy
PROTAC BCR-ABL1 ligand 1
T13832
Synonym:
Target: Others
Carboxyamidotriazole Orotate
T14871
Synonym: L-651582 Orotate,CAI Orotate
Target: Calcium Channel
Imatinib
T6230
Synonym: STI571,CGP057148B,ST-1571
Target: SARS-CoV, Bcr-Abl, PDGFR, c-Kit, Autophagy
AST 487
T4053
Synonym: NVP-AST 487
Target: VEGFR, FLT, c-RET, Bcr-Abl, c-Kit
Dasatinib monohydrate
T1448L
Synonym: BMS-354825 Monohydrate
Target: Apoptosis, Bcr-Abl, Src, c-Kit, Ephrin Receptor, Autophagy
Nilotinib monohydrochloride monohydrate
T2147
Synonym: Nilotinib (monohydrochloride monohydrate),AMN107 (monohydrochloride monohydrate)
Target: Bcr-Abl, Autophagy
Imatinib Mesylate
T1621
Synonym: ST-1571 Mesylate,STI-571,CGP-57148B
Target: Bcr-Abl, PDGFR, c-Kit, Autophagy
AG1024
T2693
Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200
Target: Apoptosis, IGF-1R
BGG463
T4618
Synonym: K 0859
Target: Bcr-Abl, CDK
Nilotinib hydrochloride
T22378
Synonym: AMN-107 HCl
Target: Bcr-Abl, Autophagy
CHMFL-ABL-039
T10799
Synonym:
Target: Bcr-Abl
Vamotinib
T63746
Synonym: PF-114
Target: Apoptosis, Tyrosine Kinases, Bcr-Abl
PD180970
T23128
Synonym: PD 180970
Target: Bcr-Abl, Src, c-Kit
1 2 3
Cat No. Product Name Synonyms Targets
T3S1553 Trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein COX , Endogenous Metabolite
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TargetMol