Search Result

Search Results for " 表观遗传 "

Targets

Influenza Virus Histone Methyltransferase Autophagy

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T3257	UNC0638		Influenza Virus , Histone Methyltransferase , Autophagy
	UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets.		Influenza Virus , Histone Methyltransferase , Autophagy
T7900	BAY-474		c-Met/HGFR
	BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe		c-Met/HGFR
T13748	L-2-Hydroxyglutaric acid disodium	(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase , Mitochondrial Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ...		Histone Demethylase , Mitochondrial Metabolism
T1816	(Z)-JIB-04	NSC 693627,Z-JIB-04	Others
	(Z)-JIB-04 (NSC 693627) is an isomer of JIB-04.		Others
T0499	Oxybenzone	KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567	Apoptosis , Retinoid Receptor , Autophagy
	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.		Apoptosis , Retinoid Receptor , Autophagy
T39252	TAK-418		Histone Demethylase
	TAK-418 is a selective and orally active inhibitor of LSD1/KDM1A enzyme with an IC50 of 2.9 nM. TAK-418 unlocks abnormal epigenetic mechanisms and improves autism symptoms in models of neurodevelopmental disorders.		Histone Demethylase
T5198	Bobcat339	Bobcat339 hydrochloride	DNA Methyltransferase
	Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.		DNA Methyltransferase
T6793	BRD7552		Others
	BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.		Others
T7400	RRX-001		Apoptosis , Dehydrogenase , Parasite
	RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity		Apoptosis , Dehydrogenase , Parasite
T35363	HM-cytosine	5hmC,5-Hydroxymethylcytosine	Others
	HM-cytosine (5hmC) is a naturally occurring component of mammalian genomic DNA and is thought to be the sixth base of DNA [1]. HM-cytosine is an intermediate metabolite for demethylation of active DNA [2]. HM-cytosine is...		Others
T27423	GNE-375	GNE375,GNE 375	Epigenetic Reader Domain , Carboxypeptidase , CDK
	GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.		Epigenetic Reader Domain , Carboxypeptidase , CDK
T4393	MS049 2HCl (1502816-23-0(free base))		Histone Methyltransferase
	MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and...		Histone Methyltransferase
T15784	LP99		Epigenetic Reader Domain
	LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9).		Epigenetic Reader Domain
T82458	Epigenetic factor-IN-1		Sirtuin
	Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7. It is utilized in the study of liver cancer [1].		Sirtuin
T63103	PRMT5-IN-17
	PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor that exhibits antitumour activity. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications.
T76132	β-N-Acetylhexosaminidase
	β-N-Acetylhexosaminidase is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in oligosaccharides for epigenetic applications [1] .
T79131	KAT modulator-1		Histone Acetyltransferase
	KAT modulator-1 (Compound 3), an epigenetics research tool, selectively interacts with the full-length p300 protein but not its catalytic domain [1].		Histone Acetyltransferase
T63138	PRMT5-IN-16
	PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with antitumour effects. PRMT5, a protein arginine methyltransferase, is a novel anti-tumour target associated with epigenetic modifications.
T76413	PRMT5-IN-22
	PRMT5-IN-22 (compound 53), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a protein arginine methyltransferase, PRMT5 represents a novel anti-tumor target associated with e...
T76414	PRMT5-IN-23
	PRMT5-IN-23 (compound 50), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a novel anti-tumor target associated with epigenetic modification, PRMT5 belongs to the protein ar...
T61012	Bobcat339 hydrochloride
	Bobcat339 hydrochloride can be used in the field of epigenetics and as a starting point for new therapeutics targeting DNA methylation and gene transcription. Bobcat339 hydrochloride is a potent and selective cytosine-ba...
T80212	Lunasin		Parasite
	Lunasin, a bioactive peptide derived from soybean, exhibits antioxidant, anti-inflammatory, anticancer, and anti-aging properties. It operates through an epigenetic mechanism linked to histone acetylation and has the abi...		Parasite
T9634	Bomedemstat
	Bomedemstat (IMG-7289) is an orally active and irreversible inhibitor of the epigenetically active lysine-specific demethylase 1 (LSD1) in mouse models of myeloproliferative neoplasms (MPNs). Bomedemstat shows antineopla...
T81932	LIN28-IN-1
	LIN28-IN-1 (compound 5) is a selective inhibitor targeting the RNA-binding protein LIN28, specifically binding to its cold shock domain (CSD). This compound robustly interrupts the LIN28-let-7 miRNA interaction with an I...
T79801	TCIP 1		Epigenetic Reader Domain
	TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre...		Epigenetic Reader Domain

Compounds

UNC0638

T3257

Synonym:

Target: Influenza Virus, Histone Methyltransferase, Autophagy

L-2-Hydroxyglutaric acid disodium

T13748

Synonym: (S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

(Z)-JIB-04

T1816

Synonym: NSC 693627,Z-JIB-04

Target: Others

Oxybenzone

T0499

Synonym: KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567

Target: Apoptosis, Retinoid Receptor, Autophagy

TAK-418

T39252

Synonym:

Target: Histone Demethylase

Bobcat339

T5198

Synonym: Bobcat339 hydrochloride

Target: DNA Methyltransferase

Target: Apoptosis, Dehydrogenase, Parasite

HM-cytosine

T35363

Synonym: 5hmC,5-Hydroxymethylcytosine

Target: Others

GNE-375

T27423

Synonym: GNE375,GNE 375

Target: Epigenetic Reader Domain, Carboxypeptidase, CDK

MS049 2HCl (1502816-23-0(free base))

T4393

Synonym:

Target: Histone Methyltransferase

LP99

T15784

Synonym:

Target: Epigenetic Reader Domain

Epigenetic factor-IN-1

β-N-Acetylhexosaminidase

Target: Histone Acetyltransferase

Bobcat339 hydrochloride

Target: Epigenetic Reader Domain

Cat No.	Product Name	Synonyms	Targets
T4832	Cytosine	6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine	Endogenous Metabolite
	Cytosine (6-Aminopyrimidin-2(1H)-one) is a pyrimidine base that is a fundamental unit of nucleic acids. The deamination of cytosine alone is apparent and the nucleotide of cytosine is the prime mutagenic nucleotide in le...		Endogenous Metabolite
T5270	5-Methylcytosine		Others , DNA/RNA Synthesis , Endogenous Metabolite
	5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA. In animals, the DNA methylation of cytosine to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In plants, the methylated...		Others , DNA/RNA Synthesis , Endogenous Metabolite
T5255	5-Hydroxymethyluracil	5-(Hydroxymethyl)uracil,Hydroxymethyl Uracil,a-Hydroxythymine	Others , Endogenous Metabolite
	5-Hydroxymethyluracil (a-Hydroxythymine) is an oxidation damage product derived from thymine or 5-methylcytosine. 5-Hydroxymethyluracil is a product of thymine dioxygenase. Additional deamination products such as 5-hydro...		Others , Endogenous Metabolite

Natural Products

Cytosine

T4832

Synonym: 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine

Target: Endogenous Metabolite

5-Methylcytosine

T5270

Synonym:

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

5-Hydroxymethyluracil

T5255

Synonym: 5-(Hydroxymethyl)uracil,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Cat No.	Product Name
L1200	Epigenetics Compound Library	960 compounds
	Well-chosen 960 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L3510	Methylation Compound Library	131 compounds
	131 methylation-related compounds that can be used for high-throughput and high-content screening.
L2150	Anti-Cancer Drug Library	3159 compounds
	A unique collection of 3159 anticancer drugs for high throughput screening (HTS) and high content screening (HCS);
L3500	Histone Modification Compound Library	480 compounds
	A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L2160	Anti-Cancer Active Compound Library	3250 compounds
	A unique collection of 3250 compounds with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L2120	Anti-Cancer Clinical Compound Library	2614 compounds
	A unique collection of 2614 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS);
L2100	Anti-Cancer Compound Library	7360 compounds
	A unique collection of 7360 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L2110	Anti-Cancer Approved Drug Library	1825 compounds
	A unique collection of 1825 approved anti-cancer drugs for high throughput screening (HTS) and high content screening (HCS);
L8200	Anti-Aging Compound Library	3324 compounds
	A unique collection of 3324 anti-aging compounds for high throughput screening (HTS) and high content screening (HCS);