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Cat No. | Product Name | Synonyms | Targets |
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T4435 | E7820 | ER68203-00 | Integrin |
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells). | |||
T8560 | Angiotensin II human acetate | Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate | Apoptosis , RAAS |
Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. | |||
TP1528 | Angiotensin I/II (1-5) | Angiotensin I/II 1-5 | RAAS , Others |
Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II. | |||
TQ0317 | R1530 | R-1530,R 1530 | VEGFR , FGFR , FLT , PDGFR |
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities. | |||
TP1579 | Angiotensin I/II (1-6) | Angiotensin I/II 1-6 | RAAS , Others |
Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. | |||
T79860 | TIE-2/VEGFR-2 kinase-IN-5 | VEGFR , Tie-2 | |
TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis. | |||
T9963 | MPT0B390 | HDAC | |
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. | |||
T6885 | Marimastat | BB2516,KB-R8898,TA2516 | MMP |
Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM). | |||
T9127 | MYLS22 | Others | |
MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp... | |||
T13050 | SYP-5 | HIF/HIF Prolyl-Hydroxylase , HIF | |
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis. | |||
T4425 | JK-P3 | VEGFR | |
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format... | |||
T26046 | Razoxane | Topoisomerase | |
Razoxane is used as an antimitotic agent with immunosuppressive properties. | |||
T68455 | AP23846 | AP-23846 | Src |
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines. | |||
T0002 | Ethamsylate | Cyclonamine,Etamsylate,Dicynene,Aglumin | Prostaglandin Receptor |
Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins. | |||
T35570 | Chiauranib | CS2164 | c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase |
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-... | |||
T7575L1 | [Sar1, Ile8]-Angiotensin II acetate | RAAS | |
[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu... | |||
TP1328 | TB500 | Others | |
TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4. | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. | |||
T73368 | UniPR505 | Ephrin Receptor | |
UniPR505 is a potent EphA2 antagonist (IC50: 0.95 µM), a novel 3α-carbamoyloxy derivative with antiangiogenic properties. | |||
T7339 | Angiotensin (1-7) | Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO | RAAS , Endogenous Metabolite |
Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activiti... | |||
T67746 | IMS2186 | Others | |
IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the... | |||
T17105 | TM6089 | HIF/HIF Prolyl-Hydroxylase | |
TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia. | |||
T24804 | SM27 | SM-27,NSC-37204,SM 27,NSC37204 | FGFR |
SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours. | |||
T1777 | Nintedanib | BIBF 1120,Intedanib | VEGFR , FGFR , FLT , PDGFR , Src |
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an... | |||
T15574 | Incyclinide | COL-3,CMT-3 | MMP |
Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis. | |||
T7493 | AG-13958 | AG-013958 | VEGFR |
AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration. | |||
T2309 | Ganetespib | STA-9090 | Apoptosis , HSP , HIF |
Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. | |||
T2644 | (E)-Daporinad | Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866 | NAMPT , Transferase , Autophagy |
(E)-Daporinad (FK866) is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities. | |||
T10680 | Carebastine | Histamine Receptor | |
Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor. | |||
T5535 | ERK5-IN-2 | ERK | |
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | |||
T8491 | Vorolanib | CM082,X-82 | VEGFR , PDGFR |
Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor. | |||
T10397 | ATN-161 trifluoroacetate salt | ATN-161 TFA salt | Integrin |
ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model. | |||
T4412 | Roquinimex | Linomide,LS2616,FCF89,ABR212616 | TNF |
Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. | |||
TP1345 | Kisspeptin-10, human (TFA)(374675-21-5,FREE) | GPR , Kisspeptin | |
Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role i... | |||
T35834L | (Sar¹)-Angiotensin II acetate | RAAS | |
(Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell... | |||
T8541 | Lenvatinib mesylate | E7080 (mesylate) | VEGFR , FGFR , c-RET , PDGFR , c-Kit |
Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities. | |||
T2676 | PF-04217903 | c-Met/HGFR | |
MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. | |||
T1178 | Temozolomide | NSC 362856,TZM,CCRG 81045,TMZ | Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy |
Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. | |||
T3389 | Antitumor agent-21 | TRX818 | Others |
Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities. | |||
T4632 | NSC 6038 | 4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide | Others |
NSC-6038 (4-chloro-N,N-dipropylbenzamide) is a benzamide-based bioactive compound with a wide range of biological activities and has been shown to possess anti-inflammatory, antioxidant and anti-angiogenic activities, an... | |||
T39986 | LOX-IN-3 dihydrochloride | Lipoxygenase | |
LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities. | |||
T2384 | Pomalidomide | CC-4047 | Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues |
Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator. | |||
T7541 | PTP inhibitor 1 | PTP Inhibitor II | Phosphatase |
PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM. | |||
T39520 | Vamifeport | VIT-2763 | Ferroptosis |
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inf... | |||
T21334 | Bucillamine | DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019 | VEGFR , Antioxidant |
Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and... | |||
TP2308 | TB500 acetate(885340-08-9 free base) | Frag17-23 Acetate,TB500 Acetate | Others |
TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col... | |||
T14524 | Befetupitant | Ro67-5930 | Neurokinin receptor |
Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization. | |||
T8616 | Fasentin | N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide | transporter |
Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1. | |||
T6381 | Amifostine trihydrate | Ethyol trihydrate,WR2721,Amifostine | Others , HIF/HIF Prolyl-Hydroxylase |
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. | |||
T5122 | Alofanib | RPT835 | Apoptosis , FGFR |
Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9155 | Fumagillol | Others , Antibacterial | |
Fumagillol is a direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin. | |||
T8846 | Beta-Escin | B-escin,AESCINE | Immunology/Inflammation related |
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent. | |||
T3005 | 4-Hydroxychalcone | P-Cinnamoylphenol | Others , NF-κB |
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. | |||
T5S0331 | Isoliquiritin | Neoisoliquritin | p53 , Antifungal |
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk betwee... | |||
T4183 | Lavendustin A | RG-14355,NSC 678027 | EGFR , Tyrosinase |
lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. | |||
T25476 | Gypsogenin | Bcr-Abl | |
Gypsogenin (639-14-5) is a naturally occurring biochemical that shows anti-ABL1 kinase and anti-chronic Myelogenous Leukemia activities. | |||
T3056 | Bavachinin | Bavachinin A,7-O-Methylbavachin | PPAR |
Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity. | |||
TN1828 | Kahweol | Apoptosis , NF-κB , AMPK | |
Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity. | |||
T5761 | Notoginsenoside Ft1 | Others , HIF/HIF Prolyl-Hydroxylase | |
Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities | |||
T2961 | Notoginsenoside R1 | Sanqi glucoside R1,Sanchinoside R1 | Apoptosis , ERK , Beta Amyloid |
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties. | |||
T0724 | Formononetin | Biochanin B,Flavosil,Formononetol | Apoptosis , FGFR |
Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus. | |||
T17280 | (Z)-Guggulsterone | Apoptosis , VEGFR , Akt | |
(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. | |||
T5656 | (±)-Norcantharidin | Endothall anhydride,Norcantharidin | EGFR , c-Met/HGFR |
(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | |||
T10117 | 3'-O-Acetylhamaudol | Others | |
3'- O- Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation. | |||
T67708 | Thiolutin | Acetopyrrothin | Antibacterial , Antibiotic |
Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly. | |||
TN1087 | Deoxypodophyllotoxin | Apoptosis , Microtubule Associated , Autophagy | |
Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities. | |||
T4962 | Zingibroside R1 | Ginsenoside Z-R1 | HIV Protease |
Zingibroside R1 (Ginsenoside Z-R1) has anti-HIV-1 activity. | |||
T6S0657 | Isorhynchophylline | IsoRhy,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline | Others |
1. Isorhynchophylline (7-Isorhyncophylline) and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of an... | |||
TN1112 | Morellic acid | Others | |
Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity. | |||
T2774 | Lycorine hydrochloride | Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride | Virus Protease , HCV Protease , Antibacterial , Autophagy |
Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity. | |||
T3001 | Honokiol | NSC 293100 | ERK , HCV Protease , MEK , Akt , Autophagy |
Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. | |||
T2906 | Tanshinone IIA | Tanshinone B,Dan Shen ketone | VEGFR |
Tanshinone IIA (Tanshinone B)(Tanshinone B) is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory. | |||
T3878 | Raddeanin A | NSC382873,Anemodeanin A,Raddeanin R3 | Apoptosis , HDAC |
Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity. | |||
T7437 | 3-(3-Hydroxyphenyl)propionic Acid | m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid | Others , Endogenous Metabolite |
3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity. | |||
T7040 | Angiotensin II human | DRVYIHPF,Angiotensin II,Hypertensin II,Ang II | Apoptosis , RAAS |
Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes... | |||
TN1651 | Furanodiene | Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp | |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. | |||
T10619 | Bromelain | Apoptosis , Others | |
Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,... | |||
T2S1396 | 3-O-Acetyloleanolic acid | Apoptosis | |
3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations. | |||
T1335 | Mycophenolic acid | Mycophenolate,RS-61443 | Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal |
Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity. | |||
T3324 | Lycorine | Galanthidine,Narcissine,Amarylline,Belamarine,Licorine | Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase |
Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive. | |||
TN2429 | Capsiate | Antioxidant , TRP/TRPV Channel | |
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity. | |||
T6947 | Piperlongumine | PPLGM,Piplartine | Apoptosis , ERK , Ferroptosis , Reactive Oxygen Species , ROS , Antibacterial , Autophagy |
Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS). | |||
T1644 | Dopamine hydrochloride | Dopamine HCl,ASL279 | Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite |
Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b... | |||
T3150 | Caudatin | Apoptosis , Others | |
Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities. | |||
T38248 | 2-Ethylpyrazine | Endogenous Metabolite , NO Synthase | |
2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis thro... | |||
T2834 | Nobiletin | Hexamethoxyflavone | Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy |
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic... | |||
T19711 | Desmosterol | Desmesterol,24-Dehydrocholesterol | Endogenous Metabolite |
Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis. | |||
T1737 | Genistein | NPI 031L | Apoptosis , EGFR , Endogenous Metabolite , Autophagy |
Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities. | |||
T1082 | Benzyl isothiocyanate | Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester | Apoptosis , Antibacterial , Antibiotic |
Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog... | |||
TN1244 | 3'-Demethylnobiletin | LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis | |
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ... | |||
T2S1200 | Sinapine | Antioxidant , P-gp , AChE | |
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities. | |||
T11363 | Ganoderic acid F | Others | |
Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si... | |||
T6S0735 | Flavokawain B | Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone | Apoptosis , Others |
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... | |||
T3342 | Xanthohumol | Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV | |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ... | |||
T2S0886 | Terrestrosin D | Apoptosis , Others | |
Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action... | |||
T3860 | Isoliquiritin apioside | MMP , p38 MAPK , NF-κB | |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse... | |||
T10086 | 24-Hydroxycholesterol | Cholest-5-ene-3beta,24-diol | Liver X Receptor , NMDAR |
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcription factor LXR, which has been used in the study of cardioge... | |||
T2220 | 2-Methoxyestradiol | NSC-659853,2-MeOE2,2-ME2 | Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy |
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli... | |||
T4706 | Uridine-5'-diphosphate disodium salt | UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd | DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor |
Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction... | |||
T6670 | Silymarin | Silybin B | SARS-CoV |
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases. | |||
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Cat No. | Product Name | Species | Expression System |
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TMPJ-00763 | ANG Protein, Human, Recombinant | Human | E. coli |
Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular t... | |||
TMPJ-00303 | ANG2 Protein, Mouse, Recombinant (hFc) | Mouse | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti... | |||
TMPJ-01435 | ANG2 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus Macaque | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti... |
Cat No. | Product Name | ||
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L4800 | Angiogenesis related Compound Library | 1370 compounds | |
A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS); | |||
L5400 | Anti-Cardiovascular Disease Compound Library | 1428 compounds | |
A unique collection of 1428 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L7500 | Coagulation and Anticoagulation Compound Library | 154 compounds | |
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L6750 | PBCRBS Traditional Chinese Medicine Compound Library | 588 compounds | |
A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis. | |||
L1100 | Protease Inhibitor Library | 344 compounds | |
A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; | |||
L2300 | Ion Channel Inhibitor Library | 946 compounds | |
A unique collection of 946 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery; | |||
L2160 | Anti-Cancer Active Compound Library | 3250 compounds | |
A unique collection of 3250 compounds with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS); | |||
L2120 | Anti-Cancer Clinical Compound Library | 2614 compounds | |
A unique collection of 2614 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L2560 | Metabolism Compound Library | 2350 compounds | |
A unique collection of 2350 metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening. | |||
L5900 | CNS-Penetrant Compound Library | 516 compounds | |
A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L2110 | Anti-Cancer Approved Drug Library | 1825 compounds | |
A unique collection of 1825 approved anti-cancer drugs for high throughput screening (HTS) and high content screening (HCS); | |||
L2150 | Anti-Cancer Drug Library | 3159 compounds | |
A unique collection of 3159 anticancer drugs for high throughput screening (HTS) and high content screening (HCS); | |||
L6140 | Saccharide and Glycoside Natural Product Library | 364 compounds | |
A unique collection of 364 saccharides and glycosides compounds can be used for HTS and HCS; | |||
L2180 | Anti-Cancer Compound Library Plus | 1468 compounds | |
Well-chosen 1468 anti-tumor compounds with unique structures; | |||
L4700 | Immunology/Inflammation Compound Library | 3483 compounds | |
A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening. | |||
L2910 | Antioxidant Compound Library | 1330 compounds | |
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ... | |||
L2200 | Tyrosine Kinase Inhibitor Library | 1033 compounds | |
A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; | |||
L2100 | Anti-Cancer Compound Library | 7360 compounds | |
A unique collection of 7360 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS); | |||
L1300 | PI3K-AKT-mTOR Compound Library | 425 compounds | |
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L8720 | Pyroptosis Compound Library | 1077 compounds | |
1077 types of active small molecules associated with pyroptosis for high-throughput and high-content screening. | |||
L8600 | Ubiquitination Compound Library | 214 compounds | |
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening; | |||
L6120 | Flavonoid Natural Product Library | 477 compounds | |
A unique collection of 477 flavonoids can be used for high throughput and high content screening; | |||
L6400 | Marine Natural Product Library | 148 compounds | |
A unique collection of 148 marine natural products for high throughput screening (HTS) and high content screening (HCS); | |||
L7100 | Anti-Obesity Compound Library | 2286 compounds | |
A unique collection of 2286 anti-obesity compounds for high throughput and high content screening; | |||
L1610 | FDA-Approved Kinase Inhibitor Library | 266 compounds | |
A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening. | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 240 compounds | |
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L6820 | Tobacco Monomer Library | 750 compounds | |
A unique collection of 750 tobacco monomer compounds for high throughput screening and high content screening; |