Search Result

Search Results for " 蛋白酶体 "

Targets

540

Compounds

Natural Products

Libraries

Reagents

Cat No.	Product Name	Synonyms	Targets
T7513	Protease-Activated Receptor-2, amide	SLIGKV-NH2	Protease-activated Receptor
	Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)		Protease-activated Receptor
T7380	Protease-Activated Receptor-4		Protease-activated Receptor
	Protease-Activated Receptor-4 is the proteinase-activated receptor-4 (PAR4) agonist, with Antiplatelet Therapy		Protease-activated Receptor
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T2626	SBC-115076	SBC115076	Others , Serine/threonin kinase
	SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.		Others , Serine/threonin kinase
T6041	Oprozomib	PR-047,ONX 0912	Proteasome , Autophagy
	Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity.		Proteasome , Autophagy
T21617	MG-115	Z-LL-Nva-CHO	Proteasome
	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas...		Proteasome
T1795	Carfilzomib	PR-171	Apoptosis , Proteasome , Autophagy
	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.		Apoptosis , Proteasome , Autophagy
T6029	ONX-0914	ONX0914,PR-957,ONX 0914	Proteasome , HIV Protease , Antibacterial
	ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.		Proteasome , HIV Protease , Antibacterial
T6058	LY2886721		Beta-Secretase , BACE
	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.		Beta-Secretase , BACE
T9090	MUN57694		Proteasome
	MUN57694 is an inhibitor of 26S proteasome.		Proteasome
T10061	(1S,2S)-Bortezomib	Bortezomib	Proteasome
	(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.		Proteasome
T8464	RA-9		Apoptosis , DUB
	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.		Apoptosis , DUB
T10672	Capzimin		Others
	Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.		Others
T6910	NSC59984		p53
	NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.		p53
T13554	Arimoclomol maleate	BRX-220	HSP
	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.		HSP
T36352	Suc-Leu-Tyr-AMC
	Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; em...
T1932	B-AP15	NSC 687852	Apoptosis , DUB
	B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome.		Apoptosis , DUB
T8397	Ixazomib citrate	MLN9708	Proteasome , Autophagy
	Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.		Proteasome , Autophagy
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
T6040	Aloxistatin	E64d,Loxistatin,E64c ethyl ester	SARS-CoV , Cysteine Protease
	Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with...		SARS-CoV , Cysteine Protease
T2694	KN-62		CaMK , P2X Receptor , Autophagy
	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.		CaMK , P2X Receptor , Autophagy
T14529	Bentiromide		Others
	The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function[1]. Bentiromide is a peptide which is broken down in the pancreas by...		Others
T7854	Bortezomib-pinanediol		Proteasome
	Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.		Proteasome
T7740	Protease-Activated Receptor-4 diTFA	Protease-Activated Receptor-4 diTFA(245443-52-1(free base))	Protease-activated Receptor
	Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist		Protease-activated Receptor
TP1051L	Protein Kinase C Peptide Substrate acetate	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others
	Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple...		Others
T21521L	Papain Inhibitor acetate	GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate （70195-20-9 free base)	Others
	Papain Inhibitor acetate (Gly-Gly-Tyr-Arg) is an affinity Ligand for Papain.		Others
T50088	N-phenylthiophene-2-carboximidamide		Others
	N-phenylthiophene-2-carboximidamide is a thiophene derivative that functions as an inhibitor of protein tyrosine kinases (PTKs) and a ligand for G protein-coupled receptors (GPCRs).		Others
T1893	Parmodulin 2	ML 161	Protease-activated Receptor
	Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thromb...		Protease-activated Receptor
T13858	RA190		Proteasome
	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.		Proteasome
T7816	Ac-DEVD-pNA		Others
	Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.		Others
TQ0012	AZ3451		Protease-activated Receptor
	AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).		Protease-activated Receptor
T40034	GNF-8625 monopyridin-N-piperazine hydrochloride		Trk receptor
	GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.		Trk receptor
T21890	JLK6		Gamma-secretase
	JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling		Gamma-secretase
T12220	NIC3		Others
	NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor,with anti-cancer activity.		Others
T8553	BC-1471		Others
	BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1].		Others
T7625	TRAP-6	PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)	Protease-activated Receptor
	TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).		Protease-activated Receptor
T5534	LOC14		Others
	LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM)		Others
T6870	L-685458	L-685,458	Apoptosis , Gamma-secretase
	L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.		Apoptosis , Gamma-secretase
T25821	ML359	ML-359,ML 359	Others
	ML359 is a protein disulfide isomerase inhibitor.		Others
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T3098	Vorapaxar sulfate	SCH 530348 sulfate,Zontivity,vorapaxar monosulfate	Protease-activated Receptor
	Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.		Protease-activated Receptor
T16491	PF-06446846 hydrochloride		Others
	PF-06446846 hydrochloride, an orally active and highly selective inhibitor, targets Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) translation by inducing ribosomal stalling at approximately codon 34, effectively ...		Others
T9702	Eclitasertib		RIP kinase
	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).		RIP kinase
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T3161L	BACE-IN-1 acetate	BACE-IN-1 acetate (350228-37-4，Free base)	BACE
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...		BACE
T41308L	Gly-Phe β-naphthylamide acetate	Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)	Others
	Gly-Phe β-naphthylamide acetate is the substrate of Cathepsin C and can be used for research on the function of cathepsin C, intralysosomal hydrolysis and lysosomal membrane permeability.		Others
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T5401	GSK2983559 active metabolite	GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1	RIP kinase
	GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.		RIP kinase

Compounds

Protease-Activated Receptor-2, amide

T7513

Synonym: SLIGKV-NH2

Target: Protease-activated Receptor

Protease-Activated Receptor-4

T7380

Synonym:

Target: Protease-activated Receptor

VR23

T7016

Synonym:

Target: Apoptosis, Proteasome, Caspase

Target: Proteasome, Caspase, Autophagy

SBC-115076

T2626

Synonym: SBC115076

Target: Others, Serine/threonin kinase

Oprozomib

T6041

Synonym: PR-047,ONX 0912

Target: Proteasome, Autophagy

MG-115

T21617

Synonym: Z-LL-Nva-CHO

Target: Apoptosis, Proteasome, Autophagy

ONX-0914

T6029

Synonym: ONX0914,PR-957,ONX 0914

Target: Proteasome, HIV Protease, Antibacterial

LY2886721

T6058

Synonym:

Target: Beta-Secretase, BACE

Target: Apoptosis, DUB

Target: Apoptosis, DUB

Ixazomib citrate

T8397

Synonym: MLN9708

Target: Proteasome, Autophagy

MLN9708

T2016

Synonym: Ixazomib Citrate

Target: Proteasome

Aloxistatin

T6040

Synonym: E64d,Loxistatin,E64c ethyl ester

Target: SARS-CoV, Cysteine Protease

KN-62

T2694

Synonym:

Target: CaMK, P2X Receptor, Autophagy

Bortezomib-pinanediol

T7854

Synonym:

Target: Proteasome

Protease-Activated Receptor-4 diTFA

T7740

Synonym: Protease-Activated Receptor-4 diTFA(245443-52-1(free base))

Target: Protease-activated Receptor

Protein Kinase C Peptide Substrate acetate

TP1051L

Synonym: Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)

Target: Others

Papain Inhibitor acetate

T21521L

Synonym: GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate （70195-20-9 free base)

Target: Others

N-phenylthiophene-2-carboximidamide

Target: Protease-activated Receptor

Target: Protease-activated Receptor

GNF-8625 monopyridin-N-piperazine hydrochloride

Target: Gamma-secretase

Synonym: PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)

Target: Protease-activated Receptor

Target: Apoptosis, Gamma-secretase

ML359

T25821

Synonym: ML-359,ML 359

Target: Others

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

Vorapaxar sulfate

T3098

Synonym: SCH 530348 sulfate,Zontivity,vorapaxar monosulfate

Target: Protease-activated Receptor

PF-06446846 hydrochloride

Target: Proton pump, Cysteine Protease

BACE-IN-1 acetate

T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Gly-Phe β-naphthylamide acetate

T41308L

Synonym: Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)

GSK2983559 active metabolite

T5401

Synonym: GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1

Target: RIP kinase

Cat No.	Product Name	Synonyms	Targets
T15702	Lactacystin		Proteasome
	Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and a...		Proteasome
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
T4839	Ac-Ala-OH	N-Acetylalanine,N-Acetyl-L-alanine	Others , Endogenous Metabolite
	Ac-Ala-OH (N-Acetyl-L-alanine) is a substrate for Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Myelin basic protein, GTP-binding nuclear protein Ran, Tropomyosin alpha 4 chain, HIV-1 Rev binding pro...		Others , Endogenous Metabolite
T2O2730	L-Serine	(S)-Serine,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid	Endogenous Metabolite
	L-Serine (serine) is a non-essential amino acid in humans, L-Serine is present and functionally important in many proteins.L-Serine is also found at the active site of the serine protease enzyme class that includes tryps...		Endogenous Metabolite
T3793	(20R)-Ginsenoside Rh1	20(R)-Ginsenoside Rh1	Others
	(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) can inhibit the thrombin-induced conversion of fibrinogen to fibrin.		Others
T6808	Coelenterazine	Oplophorus luciferin,Coelenteramine	Others
	Coelenterazine (Coelenteramine) is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.		Others
T16012	Marizomib	NPI-0052,Salinosporamide A,ML858	Proteasome
	Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv...		Proteasome
T1214	Ribostamycin sulfate	Vistamycin sulfate	Antibacterial , Antibiotic
	Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome.		Antibacterial , Antibiotic
T3813	20(R)-Ginsenoside Rh2	(20R)Ginsenoside Rh2,Ginsenoside Rh2	Apoptosis , MMP , HSV
	20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.		Apoptosis , MMP , HSV
TN1299	Desmethylglycitein	6,7,4'-Trihydroxyisoflavone	PI3K , CDK , PKC
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.		PI3K , CDK , PKC
T4S0181	Hinokiflavone		MMP , BCL , E1/E2/E3 Enzyme
	Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...		MMP , BCL , E1/E2/E3 Enzyme
T6830	Epoxomicin	BU-4061T,BU-4061T,Aids010837	Apoptosis , Proteasome
	Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited...		Apoptosis , Proteasome
T3786	Tomatine	lycopersicin	Apoptosis , Proteasome
	Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.		Apoptosis , Proteasome
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T7917	4'-Hydroxychalcone	2-Benzal-4-Hydroxyacetophenone	Proteasome
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity		Proteasome
T2887	Trigonelline	Trigenolline	Apoptosis , Others , Ferroptosis , Endogenous Metabolite
	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Apoptosis , Others , Ferroptosis , Endogenous Metabolite
T3880	Silydianin	Silidianin	Phosphatase
	Silydianin (Silidianin) exerts inhibition of UGT in human liver. Silydianin exerts inhibition of OATP1B1, OATP1B3 (unknown origin) expressed in HEK293 cells. Silydianin exerts inhibition of OATP2B1 (unknown origin) expre...		Phosphatase
T3419	Chelerythrine chloride		Apoptosis , BCL , PKC , Autophagy
	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.		Apoptosis , BCL , PKC , Autophagy
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T2205	Acefylline	Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
	Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help...		TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
T5S0788	Oroxin A	Baicalein 7-O-glucoside	PPAR
	Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.		PPAR
TN1136	Procyanidin A1	Proanthocyanidin A1	LDL , Calcium Channel , PKC
	Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.		LDL , Calcium Channel , PKC
T6758	Anisomycin	Flagecidin,NSC 76712,Wuningmeisu C	Apoptosis , DNA/RNA Synthesis , Antibacterial , Antibiotic , JNK
	Anisomycin (NSC-76712) is an antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
T3343	5-methoxyflavone	5-methoxy-2-phenylchromen-4-one	DNA/RNA Synthesis
	5-methoxyflavone (5-methoxy-2-phenylchromen-4-one) is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.		DNA/RNA Synthesis
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T2745	18α-Glycyrrhetinic acid	Enoxolone,Glycyrrhetinic acid	Apoptosis , NF-κB , Proteasome
	18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.		Apoptosis , NF-κB , Proteasome
T5214	Cholesteryl linoleate	CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester	Others , Endogenous Metabolite
	Cholesteryl linoleate (Linoleic Acid cholesteryl ester) is a cholesterol ester found in LDL. Cholesteryl linoleate is transferred to the plasma membrane of macrophages and CHO cells expressing 15-lipoxygenase (15-LO) via...		Others , Endogenous Metabolite
TN1711	Gossypetin		Antioxidant , p38 MAPK , MAPK , Antibacterial
	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...		Antioxidant , p38 MAPK , MAPK , Antibacterial
TN1150	Procyanidin B3		Histone Acetyltransferase
	Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.		Histone Acetyltransferase
T5S0581	Sec-O-Glucosylhamaudol	Hamaudol 3-glucoside	Others , Opioid Receptor
	Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal Sec-O-Glucosylhamaudo...		Others , Opioid Receptor
TN1470	Cassiaside B2		Phosphatase , MAO , 5-HT Receptor
	Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the a...		Phosphatase , MAO , 5-HT Receptor
T7030	Anemarsaponin B		p38 MAPK , NF-κB , MEK , COX , NO Synthase
	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...		p38 MAPK , NF-κB , MEK , COX , NO Synthase
TN1702	Glycycoumarin		P450 , JNK , AMPK , Autophagy
	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.		P450 , JNK , AMPK , Autophagy
T6564	Leupeptin Hemisulfate		Serine Protease , Cysteine Protease
	Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and bloc...		Serine Protease , Cysteine Protease
T11665	Ionomycin calcium	SQ23377 calcium	Apoptosis , Calcium Channel , Antibacterial , Antibiotic , PKC
	lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly spec...
T7044	Norepinephrine	Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol	MMP , Endogenous Metabolite , Adrenergic Receptor , Autophagy
	Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. It can up-regulate the expression of vascular endothelial growth factor, matrix metalloprotei...
T2O2721	L-Cysteine	Thioserine,cysteine,L-(+)-Cysteine	Endogenous Metabolite
	L-Cysteine (L-(+)-Cysteine) is a non-essential sulfur-containing amino acid in humans. L-Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main prote...		Endogenous Metabolite
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T4115	Auraptene	7-geranyloxycoumarin	MMP , BACE
	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...		MMP , BACE
T7285	Ionomycin		Calcium Channel
	Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as ...		Calcium Channel
T6480	D-Pantothenic acid	vitamin B5,pantothenate	Others
	D-Pantothenic acid (vitamin B5) is a water-soluble vitamin ubiquitously found in plants and animal tissues with an antioxidant property. D-Pantothenic acid is a component of coenzyme A (CoA) and a part of the vitamin B2 ...		Others
T4447	S-(5'-Adenosyl)-L-methionine tosylate	SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt	Others
	S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methioni...		Others
T10933	D-Cysteine		Endogenous Metabolite , Antibacterial
	D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of the growth of E. coli. D-cysteine is mediated by D-amino acid oxidase to produce H2S, and is a neuroprotective agent against cerebellar ataxia. D-cystein...		Endogenous Metabolite , Antibacterial
T1331	Riboflavin phosphate sodium	Riboflavin 5'-phosphate sodium,Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,FMN-Na,riboflavin-5'-phosphate	Endogenous Metabolite
	Riboflavin phosphate sodium (FMN) is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. Rib...		Endogenous Metabolite
T4120	N-Methylsarcosine	N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG	Endogenous Metabolite
	N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of p...		Endogenous Metabolite
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T4725	N-Acetyl-D-mannosamine	2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE	Others , Endogenous Metabolite
	N-Acetyl-D-mannosamine (2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE) is a monosaccharide that is used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ...		Others , Endogenous Metabolite
T19117	3-Deoxyglucosone	3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX , Glucagon Receptor
	3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGE...		GPX , Glucagon Receptor
T38108	Fulvic Acid		Antioxidant , PDE
	Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabolite isolated from Penicillium for the first time. Fulvic Ac...		Antioxidant , PDE
T75623	Sadopeptins A
	Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
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Natural Products

Synonym: Celastrol,Tripterine

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Ac-Ala-OH

T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine

Target: Others, Endogenous Metabolite

L-Serine

T2O2730

Synonym: (S)-Serine,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid

Target: Endogenous Metabolite

(20R)-Ginsenoside Rh1

T3793

Synonym: 20(R)-Ginsenoside Rh1

Target: Others

Coelenterazine

T6808

Synonym: Oplophorus luciferin,Coelenteramine

Target: Others

Marizomib

T16012

Synonym: NPI-0052,Salinosporamide A,ML858

Target: Proteasome

Ribostamycin sulfate

T1214

Synonym: Vistamycin sulfate

Target: Antibacterial, Antibiotic

20(R)-Ginsenoside Rh2

T3813

Synonym: (20R)Ginsenoside Rh2,Ginsenoside Rh2

Target: Apoptosis, MMP, HSV

Desmethylglycitein

TN1299

Synonym: 6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Hinokiflavone

T4S0181

Synonym:

Target: MMP, BCL, E1/E2/E3 Enzyme

Epoxomicin

T6830

Synonym: BU-4061T,BU-4061T,Aids010837

Target: Apoptosis, Proteasome

Tomatine

T3786

Synonym: lycopersicin

Target: Apoptosis, Proteasome

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

4'-Hydroxychalcone

T7917

Synonym: 2-Benzal-4-Hydroxyacetophenone

Target: Proteasome

Trigonelline

T2887

Synonym: Trigenolline

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

Chelerythrine chloride

T3419

Synonym:

Target: Apoptosis, BCL, PKC, Autophagy

Ethyl 3,4-dihydroxybenzoate

T5684

Synonym:

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Acefylline

T2205

Synonym: Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Oroxin A

T5S0788

Synonym: Baicalein 7-O-glucoside

Target: PPAR

Procyanidin A1

TN1136

Synonym: Proanthocyanidin A1

Target: LDL, Calcium Channel, PKC

Anisomycin

T6758

Synonym: Flagecidin,NSC 76712,Wuningmeisu C

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, JNK

5-methoxyflavone

T3343

Synonym: 5-methoxy-2-phenylchromen-4-one

Target: DNA/RNA Synthesis

Scoulerine

TN2190

Synonym:

Target: Apoptosis, Beta-Secretase, BACE, Parasite

18α-Glycyrrhetinic acid

T2745

Synonym: Enoxolone,Glycyrrhetinic acid

Target: Apoptosis, NF-κB, Proteasome

Cholesteryl linoleate

T5214

Synonym: CE(18:2(9Z,12Z)),Cholesterol Linoleate,Linoleic Acid cholesteryl ester

Target: Others, Endogenous Metabolite

Gossypetin

TN1711

Synonym:

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Procyanidin B3

TN1150

Synonym:

Target: Histone Acetyltransferase

Sec-O-Glucosylhamaudol

T5S0581

Synonym: Hamaudol 3-glucoside

Target: Others, Opioid Receptor

Cassiaside B2

TN1470

Synonym:

Target: Phosphatase, MAO, 5-HT Receptor

anemarsaponin B

T7030

Synonym:

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Glycycoumarin

TN1702

Synonym:

Target: P450, JNK, AMPK, Autophagy

Leupeptin Hemisulfate

T6564

Synonym:

Target: Serine Protease, Cysteine Protease

Ionomycin calcium

T11665

Synonym: SQ23377 calcium

Target: Apoptosis, Calcium Channel, Antibacterial, Antibiotic, PKC

Norepinephrine

T7044

Synonym: Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol

Target: MMP, Endogenous Metabolite, Adrenergic Receptor, Autophagy

L-Cysteine

T2O2721

Synonym: Thioserine,cysteine,L-(+)-Cysteine

Target: Endogenous Metabolite

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Auraptene

T4115

Synonym: 7-geranyloxycoumarin

Target: Calcium Channel

D-Pantothenic acid

T6480

Synonym: vitamin B5,pantothenate

Target: Others

S-(5'-Adenosyl)-L-methionine tosylate

T4447

Synonym: SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt

Target: Endogenous Metabolite, Antibacterial

Riboflavin phosphate sodium

T1331

Synonym: Riboflavin 5'-phosphate sodium,Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,FMN-Na,riboflavin-5'-phosphate

Target: Endogenous Metabolite

N-Methylsarcosine

T4120

Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG

Target: Endogenous Metabolite

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

N-Acetyl-D-mannosamine

T4725

Synonym: 2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE

Target: Others, Endogenous Metabolite

3-Deoxyglucosone

T19117

Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

Target: GPX, Glucagon Receptor

Fulvic Acid

T38108

Synonym:

Target: Antioxidant, PDE

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Cat No.	Product Name
L1100	Protease Inhibitor Library	344 compounds
	A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
L1610	FDA-Approved Kinase Inhibitor Library	266 compounds
	A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L9400	PPI Inhibitor Library	490 compounds
	A unique collection of 490 PPI-related compounds for drug screening;
L2200	Tyrosine Kinase Inhibitor Library	1033 compounds
	A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L3500	Histone Modification Compound Library	480 compounds
	A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);
L7500	Coagulation and Anticoagulation Compound Library	154 compounds
	A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
L3510	Methylation Compound Library	131 compounds
	131 methylation-related compounds that can be used for high-throughput and high-content screening.
L4700	Immunology/Inflammation Compound Library	3483 compounds
	A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
L9410	Covalent Inhibitor Library	1949 compounds
	A unique collection of 1949 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.
L3200	Autophagy Compound Library	1248 compounds
	A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L3700	JAK-STAT Compound Library	256 compounds
	A unique collection of 256 JAK/STAT signaling targeted compounds for high throughput and high content screening;
L1120	AMPK-Targeted Compound Library	80 compounds
	80 well-chosen unique AMPK-targeted small molecules；
L3800	NF-κB Signaling Compound Library	740 compounds
	A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...
L8000	Stem Cell Differentiation Compound Library	1213 compounds
	A unique collection of 1213 stem cell differentiation signaling targeted compounds for high throughput and high content screening;
L8300	Chromatin Modification Compound Library	256 compounds
	A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS);