细胞骨架 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T24494	MP265	MP-265,MP 265	Others
	MP265 disrupts the MreB cytoskeleton and has antiproliferative effects.		Others
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T28001	MDK-6983	MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy
	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.		Autophagy
T6626	PF-3758309	PF-309,PF-03758309,PF 3758309	Apoptosis , PAK
	PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.		Apoptosis , PAK
T2011	RKI1313	RKI 1313,RKI-1313	ROCK
	RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.		ROCK
T3580	FIPI	5-Fluoro-2-indolyl deschlorohalopemide	Phospholipase , Autophagy
	FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell s...		Phospholipase , Autophagy
T77504	JAK1/2/3 Inhibitor 1		PKA
	JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell lines. It inhibits the growth of cancer cells by binding to the c...		PKA
T50056	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide		Others
	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordina...		Others
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T78591	Zoxamide	RH-7281
	Zoxamide (RH-7281) is an oomycete-specific fungicide that impedes nuclear division in Phytophthora capsici germlings and disrupts the microtubule cytoskeleton [1] [2].
T72552	Antitumor agent-88
	Antitumor agent-88, a competitive inhibitor of CYP1A1 (K i: 1.4 μM), demonstrates significant antimitotic activity by arresting cells in the G2/M phase and disrupting the microtubule network and cytoskeleton in CYP1A1-ex...
T82877	Biotin-myelin basic protein (94-102)
	Biotin-myelin basic protein (94-102) is a peptide fragment crucial for myelin adhesion within the nervous system, facilitating myelination. This protein contributes to signal transduction by interacting as a membrane act...
T16386	Ombrabulin hydrochloride	AVE8062 (hydrochloride),AC7700 (hydrochloride)	Microtubule Associated
	Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells and has antivascular effects. Ombrabulin is a tubulin polymeriz...		Microtubule Associated
T63984	PF-3758309 dihydrochloride
	PF-3758309 dihydrochloride is a potent, reversible, orally active, ATP-competitive PAK4 inhibitor with a Kd value of 2.7 nM and a Ki value of 18.7 nM. PF-3758309 dihydrochloride exhibits the expected cellular functions o...
T83661	17(R,S)-Benzo-Resolvin D1	17(R,S)-Benzo-RvD1,Benzo-RvD1
	Benzo-resolvin D1 (benzo-RvD1), a derivative of the specialized pro-resolving mediator (SPM) RvD1, effectively reduces PDGF-BB-induced cytoskeletal alterations and PDGF-triggered migration in isolated human vascular smoo...
T80253	S3 Fragment
	S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac...
T74461	Chalcones A-N-5
	Chalcones A-N-5, a trihydroxy chalcone derivative, exhibits no cytotoxicity at concentrations below 100 µM (with IC 50 > 1 mM) and notably enhances cell proliferation. It is particularly effective in encouraging neuronal...

Compounds

MP265

T24494

Synonym: MP-265,MP 265

Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

Target: Autophagy

PF-3758309

T6626

Synonym: PF-309,PF-03758309,PF 3758309

Target: Apoptosis, PAK

RKI1313

T2011

Synonym: RKI 1313,RKI-1313

Target: ROCK

FIPI

T3580

Synonym: 5-Fluoro-2-indolyl deschlorohalopemide

Target: Phospholipase, Autophagy

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide

T50056

Synonym:

Target: Others

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Biotin-myelin basic protein (94-102)

T82877

Synonym:

Target:

Ombrabulin hydrochloride

T16386

Synonym: AVE8062 (hydrochloride),AC7700 (hydrochloride)

Target: Microtubule Associated

PF-3758309 dihydrochloride

T63984

Synonym:

Target:

17(R,S)-Benzo-Resolvin D1

T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

Cat No.	Product Name	Synonyms	Targets
T5S1261	Methylophiopogonanone B		Ras
	1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.		Ras
T20945	2,4-D	Hedonal,Macondray,2,4-D acid,Chloroxone	DNA/RNA Synthesis
	2,4-Dichlorophenoxyacetic acid (Hedonal) is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ingredient in herbicides used to disrupts the acti...		DNA/RNA Synthesis
T17155	Trabectedin	Ecteinascidin 743,ET-743	Apoptosis , Reactive Oxygen Species
	Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7/DXR cells with IC50 values of 0...		Apoptosis , Reactive Oxygen Species
TN1694	Gliotoxin		Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
T35782	Swinholide A	MK-7684	Antifungal
	Swinholide A is a polyketone compound that can be extracted from sponges and binds to actin to dimerize actin with Kd of about 50 nM. Swinholide A is a cytotoxin that stabilizes actin dimers and severs actin filaments. S...		Antifungal

Natural Products

Methylophiopogonanone B

Synonym: Hedonal,Macondray,2,4-D acid,Chloroxone

Target: DNA/RNA Synthesis

Trabectedin

T17155

Synonym: Ecteinascidin 743,ET-743

Target: Apoptosis, Reactive Oxygen Species

Gliotoxin

TN1694

Synonym:

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Cat No.	Product Name
L1310	Cytoskeletal Signaling Pathway Compound Library	773 compounds
	A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS；
L6000	Natural Product Library for HTS	4320 compounds
	A unique collection of 4320 pure natural products and their derivatives with known biological activity for drug discovery, pharmacological study, stem cell differentiation, fingerprint study and quality research, and can...
DO1200	SmartTM Library	53200 compounds

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