Search Result

Search Results for " 免疫与炎症 "

Targets

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T10389	Aspartyl-alanyl-diketopiperazine	DA-DKP	Interleukin
	Aspartyl-alanyl-diketopiperazine (DA-DKP) is a known immunomodulatory molecule from the N terminus of human albumin.		Interleukin
T21608L	β-Interleukin I (163-171), human Acetate	β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)	Others
	β-Interleukin I (163-171), human Acetateis a peptide that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.		Others
T9631	IRAK-4 protein kinase inhibitor 2		IRAK
	IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).		IRAK
T10389L	Aspartyl-alanyl-diketopiperazine acetate	DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)	Others
	Aspartyl-alanyl-diketopiperazine acetate (DA-DKP) (DA-DKP) can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy.		Others
T41303	Isoflupredone	Delta-Fluorocortisone,Isoflupredona,Isoflupredonum,9-Fluoroprednisolone	Others
	Isoflupredone (Isoflupredonum) is a synthetic corticosteroid that acts in vivo by binding to glucocorticoid and corticosteroid receptors in animals (such as horses) to inhibit inflammatory cells and inhibit the expressio...		Others
T9137	SN-011	[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING
	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.		STING
T15096	Delgocitinib	JTE-052,Corectim（Delgocitinib）	Tyrosine Kinases , JAK
	Delgocitinib (Corectim(Delgocitinib)) is a potent and specific JAK inhibitor with an IC50 value of 2.8, 2.6, 13 and 58 nM against JAK1, JAK2, JAK3 and Tyk2. Delgocitinib is involved in a variety of inflammatory and autoi...		Tyrosine Kinases , JAK
T50107	Ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate		Others
	ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate is a synthetic compound belonging to the curcumin family. It is involved in the regulation of immune response and inflammation through ...		Others
T10865	Cot inhibitor-1		TNF , MAPK
	Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a...		TNF , MAPK
T73695	Canakinumab	ACZ 885,Ilaris	IL Receptor
	Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab...		IL Receptor
T61025	GSK-1482160		P2X Receptor
	GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G...		P2X Receptor
T36503	Sodium Hydrogen Sulfide (hydrate)		Others
	Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul...		Others
T4391	Syk Inhibitor II dihydrochloride	Syk Inhibitor II (hydrochloride)	Others , Tyrosine Kinases , Syk , PKC , BTK
	Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun...		Others , Tyrosine Kinases , Syk , PKC , BTK
T79094	Bromodomain inhibitor-12 (edisylate)		Epigenetic Reader Domain
	Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].		Epigenetic Reader Domain
T78208	Leramistat	HMC-C-01-A,MBS2320	Mitochondrial Metabolism
	Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune ski...		Mitochondrial Metabolism
T64200	C5aR-IN-2
	C5aR-IN-2 is a potent inhibitor of C5aR. C5aR-IN-2 has shown potential for the study of inflammatory diseases.
T80131	C5a Anaphylatoxin (human)		Complement System
	C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses, including allergic asthma [1] [2].		Complement System
T80538	Lib2-1
	Lib2-1, a macrocyclic peptide, inhibits the interaction between IL-17C and IL-17RE and is applicable in the study of autoimmune and inflammatory diseases [1].
T78205	ROCK2-IN-6 hydrochloride		ROCK
	ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1].		ROCK
T73262	C5aR-IN-3
	C5aR-IN-3, a potent C5aR inhibitor, holds potential for inflammation disease research due to its ability to counteract increased C5a levels, which are linked to autoimmune and inflammatory disorders.
T82020	J5 peptide	Myelin basic protein (85-99) antagonist
	J5 peptide, an MBP inhibitor, competitively inhibits the binding of MBP 85-99 to HLA-DR2, and mitigates PLP 139-151/MBP 85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. It is utilized in research pe...
T79624	PDE4-IN-14
	PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including inflammatory and immune disorders, cancer, and metabolic diseases [...
T73261	C5aR-IN-1
	C5aR-IN-1, a potent inhibitor of C5aR, is linked with the potential to research inflammatory diseases. This association is due to the elevated levels of C5a, which are connected with autoimmune and inflammatory disorders...
T78744	IRAK4-IN-24		IRAK
	IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.		IRAK
T76840	Vunakizumab
	Vunakizumab (Anti-Human IL17A Recombinant Antibody), a recombinant human IgGκ monoclonal antibody, specifically targets and inhibits IL-17A's interaction with its receptor, making it useful for researching autoimmune con...
T80964	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
	Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) acts as a T cell proliferation activator by promoting the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner and is utilized...
T81027	TCRS-417	T417
	TCRS-417 (T417), a small molecule compound, selectively binds to the interface between PBX1 and its specific DNA target sequence, disrupting the PBX1-DNA interaction. This compound has potential research applications in ...
T76040	Dusquetide TFA
	Dusquetide (SGX942) TFA, a first-in-class innate defense regulator (IDR), modulates the innate immune response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by interac...
T63423	AFM-30a hydrochloride
	AFM-30a hydrochloride is a potent and highly selective inhibitor of protein arginine deiminase 2 (PAD2). aFM-30a hydrochloride binds to PAD2 (EC50: 9.5 μM) and also inhibits H3 guanylation (EC50: 0.4 μM). aFM-30a hydroch...
T74910	ODN 24888
	ODN 24888, a guanine-modified inhibitory oligonucleotide (INH-ODN), effectively inhibits TLR7/TLR9-mediated signaling, reducing IFN-α levels and NF-κB activation, and suppressing IL-6 release. This compound plays a role ...
T76156	Sphingomyelin phosphodiesterase
	Sphingomyelin phosphodiesterase, a hydrolase, plays a crucial role in sphingomyelin metabolism by catalyzing the conversion of sphingomyelin into phosphocholine and ceramide. Furthermore, it is instrumental in cellular d...
T63220	Bromodomain inhibitor-9
	Bromodomain inhibitor-9 is an inhibitor of Bromodomains that selectively inhibits the activity of BRD4-1 with a Kd value of 12 nM. Bromodomain inhibitor-9 can be used in studies of diseases related to systemic or lipid m...
T78858	CGAS-IN-1
	cGAS-IN-1 (compound C20), a flavonoid that acts as a Cyclic GMP-AMP Synthase (cGAS) inhibitor, demonstrates IC50 values of 2.28 μM for human cGAS and 1.44 μM for mouse cGAS. By inhibiting the abnormal activation of cGAS ...
T80683	γ-Fibrinogen 377-395
	γ-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimen...
T80682	γ-Fibrinogen 377-395 TFA
	γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Addition...
T83681	IRBP (1-20) (human, rat) TFA	IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20), a dodecapeptide fragment of retinoid-binding protein 3, plays a crucial role in pigment regeneration by facilitating the transport of retinol and retinal bet...
T63498	ALK5-IN-6
	ALK5-IN-6 is a potent inhibitor of ALK5. ALK5-IN-6 has potential for TGF-β-related diseases and conditions, including but not limited to tumors, inflammatory diseases, fibrotic diseases, autoimmune diseases, etc.Among th...
T80973	TNF-α-IN-8
	TNF-α-IN-8 (compound I-42) is an isoindole-imide-based inhibitor of tumor necrosis factor-alpha (TNF-α) with applications in researching various diseases including cancer, heart disease, osteoporosis, and autoimmune diso...
T63114	ALK5-IN-7
	ALK5-IN-7 is an effective inhibitor of ALK5. Transforming growth factor β (TGF-β) is a multifunctional cytokine that is involved in regulating cell proliferation, differentiation, and apoptosis through autocrine, paracri...
T80653	Larixol	(+)-Larixol	Akt
	Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for immune responses. It disrupts the interaction between the β...		Akt

Compounds

Aspartyl-alanyl-diketopiperazine

T10389

Synonym: DA-DKP

Target: Interleukin

β-Interleukin I (163-171), human Acetate

T21608L

Synonym: β-Interleukin I (163-171), human Acetate(106021-96-9 Free base)

Target: Others

IRAK-4 protein kinase inhibitor 2

T9631

Synonym:

Target: IRAK

Aspartyl-alanyl-diketopiperazine acetate

T10389L

Synonym: DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)

Target: Others

Isoflupredone

T41303

Synonym: Delta-Fluorocortisone,Isoflupredona,Isoflupredonum,9-Fluoroprednisolone

Target: Others

SN-011

T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

Delgocitinib

T15096

Synonym: JTE-052,Corectim（Delgocitinib）

Target: Tyrosine Kinases, JAK

ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate

Synonym: ACZ 885,Ilaris

Sodium Hydrogen Sulfide (hydrate)

T36503

Synonym:

Target: Others

Syk Inhibitor II dihydrochloride

T4391

Synonym: Syk Inhibitor II (hydrochloride)

Target: Others, Tyrosine Kinases, Syk, PKC, BTK

Bromodomain inhibitor-12 (edisylate)

T79094

Synonym:

Target: Epigenetic Reader Domain

Leramistat

T78208

Synonym: HMC-C-01-A,MBS2320

Target: Mitochondrial Metabolism

C5a Anaphylatoxin (human)

T80131

Synonym:

Target: Complement System

ROCK2-IN-6 hydrochloride

Synonym: Myelin basic protein (85-99) antagonist

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)

AFM-30a hydrochloride

Sphingomyelin phosphodiesterase

T76156

Synonym:

Target:

Bromodomain inhibitor-9

γ-Fibrinogen 377-395 TFA

T80682

Synonym:

Target:

IRBP (1-20) (human, rat) TFA

T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

Cat No.	Product Name	Synonyms	Targets
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T4938	Potassium 1H-indol-3-yl sulfate	Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR , Endogenous Metabolite
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...		AhR , Endogenous Metabolite

Natural Products

Allicin

T3123

Synonym:

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Potassium 1H-indol-3-yl sulfate

T4938

Synonym: Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Cat No.	Product Name
L4700	Immunology/Inflammation Compound Library	3483 compounds
	A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
L6720	Anti-COVID-19 Traditional Chinese Medicine Compound Library	1162 compounds
	A unique collection of 1162 monomers from 60 TCM plants, a powerful tool for anti-COVID-19 drug discovery, can be used for HTS and HCS screening；
L6600	Anti-Gastroenteritis Natural Product Library	223 compounds
	A unique collection of 223 natural products related to gastroenteritis for high throughput screening (HTS) and high content screening (HCS);
L1100	Protease Inhibitor Library	344 compounds
	A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
L9000	Apoptosis Compound Library	1796 compounds
	A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
L3600	Cytokine Inhibitor Library	613 compounds
	A unique collection of 613 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
L2540	Gut Microbial Metabolite Library	614 compounds
	A unique collection of 614 gut microbial metabolites which can be used for HTS and HCS;
L3300	Histamine & Melatonin Receptor-Targeted Compound Library	155 compounds
	A unique collection of 155 compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L3800	NF-κB Signaling Compound Library	740 compounds
	A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;
L9600	Peptide Compound Library	800 compounds
	800 peptides can be used in peptide drug development and signaling transduction and mechanism study;