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Search Result

Search Results for " β-secretase "

38

Compounds

9

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T40260 β-Secretase Inhibitor II
β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specif...
T39251 β-Secretase Inhibitor I
β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity...
T3161 β-Secretase inhibitor-STA Beta-Secretase
BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
T13434 β-Secretase Inhibitor IV Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T2639 LY2811376 Beta Amyloid , Beta-Secretase , BACE
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...
T4398 LX2343 Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
T12188 NB-360 BACE
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...
T9713 δ-secretase inhibitor 11 Beta Amyloid , Caspase
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
T13253 Umibecestat CNP520 BACE
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...
T6125 Semagacestat LY450139 Beta Amyloid , Gamma-secretase
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T6202 DAPT LY-374973,GSI-IX Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
T11175 Elenbecestat E2609 Beta-Secretase , BACE
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
T6058 LY2886721 Beta-Secretase , BACE
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772 AZD3839 free base AZD3839 Beta-Secretase , BACE
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T7011 Verubecestat MK-8931 Beta-Secretase , BACE
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T62455 β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.
T3285 Eslicarbazepine Acetate Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa Beta-Secretase , Sodium Channel
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve...
T11362 Gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T3521 γ-Secretase-IN-1 Compound E Beta Amyloid , Gamma-secretase
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
T62263 γ-Secretase modulator 13 Gamma-secretase
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.
T11043 Dihydroergocristine mesylate DHEC (mesylate) Beta Amyloid
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebro...
TP1786L Amyloid β-Protein 10-20 acetate Amyloid β-Protein 10-20 acetate(152286-31-2 free base) Beta Amyloid
Amyloid β-Protein 10-20 acetate (Amyloid β-Protein 10-20 acetate (152286-31-2 free base)) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α...
T21890 JLK6 Gamma-secretase
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
T4364 Aftin-4 Aftin 4,Aftin4 Beta Amyloid , Gamma-secretase
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...
T83616 SEW06622 BACE , AChE
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.
T15184 E 2012 Gamma-secretase
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc...
T6870 L-685458 L-685,458 Apoptosis , Gamma-secretase
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T70366 PF-06663195
PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).
TP1099 M-2420 Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).
T64258 Gamma-secretase modulator 5
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60...
TP1786 β-Amyloid (10-20) Amyloid β-Protein 10-20
Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains ...
T25685 Leucyl-phenylalanine amide Leu-phe-NH2
Leucyl-phenylalanine amide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to produce amyloid β-peptide (Aβ) which is th...
T63215 COX-2-IN-22
COX-2-IN-22 is a COX-2 inhibitor (IC50: 8.6 μM) that can cross the blood-brain barrier and also exhibits inhibitory effects on AChE (IC50: 2.8 μM), BChE (IC50: 6.3 μM), β-Secretase (IC50: 15.3 μM), LOX-5 (IC50: 13.9 μM) ...
T37661 LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...
T39678 Multitarget AD inhibitor-1
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additio...
T79422 BuChE-IN-8
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic pr...
T35975 6,9-Dichloro-1,2,3,4-tetrahydroacridine
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids...
T83686 Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 is a fluorogenic substrate designed for the quantification of β-secretase (BACE) activity. When cleaved by BACE, it liberates 7-methoxycoumarin-4-acetyl (Mca), a compound whose fluorescence, ...

Compounds

β-Secretase Inhibitor II
T40260
Synonym:
Target:
β-Secretase Inhibitor I
T39251
Synonym:
Target:
β-Secretase inhibitor-STA
T3161
Synonym:
Target: Beta-Secretase
β-Secretase Inhibitor IV
T13434
Synonym:
Target: Others
LY2811376
T2639
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE
LX2343
T4398
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy
NB-360
T12188
Synonym:
Target: BACE
δ-secretase inhibitor 11
T9713
Synonym:
Target: Beta Amyloid, Caspase
Umibecestat
T13253
Synonym: CNP520
Target: BACE
Semagacestat
T6125
Synonym: LY450139
Target: Beta Amyloid, Gamma-secretase
DAPT
T6202
Synonym: LY-374973,GSI-IX
Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy
Elenbecestat
T11175
Synonym: E2609
Target: Beta-Secretase, BACE
LY2886721
T6058
Synonym:
Target: Beta-Secretase, BACE
AZD3839 free base
T6772
Synonym: AZD3839
Target: Beta-Secretase, BACE
Verubecestat
T7011
Synonym: MK-8931
Target: Beta-Secretase, BACE
β-Secretase Inhibitor III
T62455
Synonym:
Target:
Eslicarbazepine Acetate
T3285
Synonym: Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa
Target: Beta-Secretase, Sodium Channel
gamma-Secretase Modulators
T11362
Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor
Target: Others
γ-Secretase-IN-1
T3521
Synonym: Compound E
Target: Beta Amyloid, Gamma-secretase
γ-Secretase modulator 13
T62263
Synonym:
Target: Gamma-secretase
Dihydroergocristine mesylate
T11043
Synonym: DHEC (mesylate)
Target: Beta Amyloid
Amyloid β-Protein 10-20 acetate
TP1786L
Synonym: Amyloid β-Protein 10-20 acetate(152286-31-2 free base)
Target: Beta Amyloid
JLK6
T21890
Synonym:
Target: Gamma-secretase
Aftin-4
T4364
Synonym: Aftin 4,Aftin4
Target: Beta Amyloid, Gamma-secretase
SEW06622
T83616
Synonym:
Target: BACE, AChE
E 2012
T15184
Synonym:
Target: Gamma-secretase
L-685458
T6870
Synonym: L-685,458
Target: Apoptosis, Gamma-secretase
PF-06663195
T70366
Synonym:
Target:
M-2420
TP1099
Synonym: Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
Target:
gamma-secretase modulator 5
T64258
Synonym:
Target:
β-Amyloid (10-20)
TP1786
Synonym: Amyloid β-Protein 10-20
Target:
Leucyl-phenylalanine amide
T25685
Synonym: Leu-phe-NH2
Target:
COX-2-IN-22
T63215
Synonym:
Target:
LY 2886721 Hydrochloride
T37661
Synonym:
Target:
Multitarget AD inhibitor-1
T39678
Synonym:
Target:
BuChE-IN-8
T79422
Synonym:
Target:
6,9-Dichloro-1,2,3,4-tetrahydroacridine
T35975
Synonym:
Target:
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
T83686
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5S2361 Epiberberine ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...
T3769 Tenuifolin Others , Beta-Secretase , AChE
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
T8179 Aloeresin D Beta-Secretase , BACE
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T2S1181 Aloenin Aloenin A,Aloearbonaside Beta-Secretase , AChR
1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
TN2217 Sophoflavescenol Others , Beta-Secretase , BACE , PDE , AChR , AChE
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...
T8306 Epiberberine chloride Epiberberine (chloride) Reactive Oxygen Species , Beta-Secretase , BACE , AChR , AChE
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
T4753 Imidazoleacetic acid hydrochloride I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-Imidazoleacetic acid hydrochloride Endogenous Metabolite , Antibiotic
Imidazoleacetic acid hydrochloride (I4AA) is an imidazole derivative with potential antituberculosis properties. It also used in the preparation of acyl guanidine inhibitors of β-secretase.
T4115 Auraptene 7-geranyloxycoumarin MMP , BACE
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...

Natural Products

Epiberberine
T5S2361
Synonym:
Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE
Tenuifolin
T3769
Synonym:
Target: Others, Beta-Secretase, AChE
Aloeresin D
T8179
Synonym:
Target: Beta-Secretase, BACE
Scoulerine
TN2190
Synonym:
Target: Apoptosis, Beta-Secretase, BACE, Parasite
Aloenin
T2S1181
Synonym: Aloenin A,Aloearbonaside
Target: Beta-Secretase, AChR
Sophoflavescenol
TN2217
Synonym:
Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE
Epiberberine chloride
T8306
Synonym: Epiberberine (chloride)
Target: Reactive Oxygen Species, Beta-Secretase, BACE, AChR, AChE
Imidazoleacetic acid hydrochloride
T4753
Synonym: I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-Imidazoleacetic acid hydrochloride
Target: Endogenous Metabolite, Antibiotic
Auraptene
T4115
Synonym: 7-geranyloxycoumarin
Target: MMP, BACE

Recombinant Proteins

Species：
Human (5)
Mouse (1)
Expression System：
E. coli (4)
HEK293 (2)
Tag：
His,GST (2)
His,GST (2)
His (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-03065 BACE2 Protein, Mouse, Recombinant (His) Mouse HEK293
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is th...
TMPY-00668 APP/Protease nexin-II Protein, Human, Recombinant (hFc) Human HEK293
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02110 Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02221 Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03884 Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03885 Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
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