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Search Results for " α-synuclein "

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T40541	α-Synuclein (61-75)
	α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disea...
T80151	α-Synuclein 4554W
	α-Synuclein 4554W, previously identified through intracellular library screening, is an inhibitor of α-Synuclein (aSyn) aggregation and its associated toxicity. This compound, comprising GIVNGVKA sequences, effectively r...
T9722	YTX-465		Stearoyl-CoA Desaturase (SCD)
	YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).		Stearoyl-CoA Desaturase (SCD)
T61644	α-Synuclein inhibitor 6
	α-Synuclein inhibitor 6 (compound 3ge) is a highly effective and blood-brain barrier-permeable inhibitor that targets the aggregation of α-Synuclein (α-Syn). It exhibits a potent inhibitory activity, with an IC50 value o...
T72314	α-Synuclein inhibitor 8
	α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 µM, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects ...
T61404	α-Synuclein inhibitor 3
	α-Synuclein inhibitor 3 (Compound 7g) is a potent inhibitor of α-synuclein (α -Syn) aggregation. It has potential applications in Parkinson's disease research [1].
T61611	α-Synuclein inhibitor 4
	α-Synuclein inhibitor 4 (compound 3gh) is a highly effective and blood-brain barrier-permeable inhibitor of α-Synuclein aggregation. It displays potent activity, with an IC50 value of 0.98 μM, and exhibits a remarkable i...
T61920	α-Synuclein inhibitor 7
	α- Synuclein inhibitor 7 (compound 3gf) is effective α- Synuclein ( α- Syn) aggregation inhibitor, IC50 is 1.95 μM, inhibition rate at 30μM was 85.8%. α- Synuclein inhibitor 7 has blood-brain barrier permeability.
T62131	α-Synuclein inhibitor 5
	α-Synuclein inhibitor 5 is a potent inhibitor of α-Synuclein (α-Syn) aggregation across the blood-brain barrier (IC50: 1.22 μM), with 94.3% inhibition at 30 μM.
T78842	α-Synuclein inhibitor 9
	α-Synuclein inhibitor 9 (Compound 20C) is a molecule that targets and binds to cavities within mature α-synuclein fibrils, diminishing their β-sheet content. It effectively inhibits the aggregation of A53T α-synuclein an...
T80118	α-Synuclein (61-95) (human)
	α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's dis...
T79250	PROTAC α-synuclein degrader 5		PROTACs
	PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The comp...		PROTACs
T62226	Dyrk1A/α-synuclein-IN-2
	Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM). Dyrk1A/α-synuclein-IN-2 has a high predictive CNS permeability and neuroprotective...
T76199	α-Synuclein (61-75) (TFA)
	α-Synuclein (61-75) TFA is a fragment (residues 61-75) of the abundant neuronal protein α-Synuclein, which is predominantly located in presynaptic nerve terminals. α-Synuclein serves as a potential biomarker for Parkinso...
T62096	Dyrk1A/α-synuclein-IN-1
	Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM). CNS permeability and neuroprotective activity.
T78629	PROTAC α-synuclein degrader 3		PROTACs
	PROTAC α-synuclein degrader 3 (compound 5) serves as a potent and selective agent for degrading α-synuclein and is utilized in Parkinson's disease research [1].		PROTACs
T81031	Tau protein/α-synuclein-IN-1
	Tau protein/α-synuclein-IN-1 is a dual inhibitor that not only impedes tau protein and α-synuclein but also reduces the development of α-syn inclusions in M17D neuroblastoma cells, making it a useful agent in the study o...
T4659	ELN484228		Others
	ELN484228 is a α-synuclein blocker. α-synuclein is a key protein in Parkinson’s disease.		Others
T62304	Minzasolmin	(R)-NPT200-11,UCB0599,DLX-313	Others
	Minzasolmin(DLX-313) is an alpha-synuclein misfolding inhibitor for the study of Parkinson's disease.		Others
T13048	SynuClean-D	SC-D	Others
	SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea...		Others
T76861	Cinpanemab	BIIB054	Others
	Cinpanemab (BIIB054) is a novel human monoclonal antibody with affinity for alpha-synuclein residues 1-10. Cinpanemab can be used to study Parkinson's disease and related diseases.		Others
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T83726	Tat-βsyn-degron TFA
	Tat-βsyn-degron, an α-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an α-synuclein binding domain (βsyn) representing amino acids 36-45 of β-synuclein, and a pr...
T13049	Synucleozid	NSC 377363	Others
	Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.		Others
T76889	Prasinezumab
	Prasinezumab (PRX 002), a humanized IgG1 monoclonal antibody targeting aggregated α-synuclein, shows promise for Parkinson's disease research [1].
T71174	PBT434 HBr
	PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neur...
T74974	SQ-3
	SQ-3, a quinoline analogue, demonstrates moderate selectivity towards α-synuclein aggregates (α-syn aggregates) (K i = 39.3 nM) over β-amyloid (Aβ) aggregates (K i = 230 nM). [18 F]SQ-3 exhibits foundational characterist...
T68763	PQQ-TME
	PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.
T72280	PBT434 methanesulfonate
	PBT434 methanesulfonate is an orally active, potent α-synuclein aggregation inhibitor with the ability to cross the blood-brain barrier. Acting as an iron chelator, it modulates transcellular iron trafficking, inhibits i...
T13049L	Synucleozid hydrochloride (502139-01-7 free base)	Synucleozid hydrochloride,NSC 377363 hydrochloride	Others
	Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.		Others
T83875	HUP-55
	HUP-55 is a prolyl endopeptidase inhibitor with an IC50 of 5 nM, shown to mitigate α-synuclein dimerization in Neuro2a cells, stimulate autophagy in HEK293 cells, and lower hydrogen peroxide-evoked reactive oxygen specie...
T70941	CLR01 sodium
	CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro ...
T78171	QR-0217
	QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40. Additionally, QR-0217 has been shown to alleviate memory impairments attributed to Aβ neurotoxicity [1].
T74770	D-685
	D-685, a prodrug of D-520, demonstrates enhanced anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model compared to its parent compound D-520. It effectively reduces the buildup of human α-syn...
T83328	4A7C-301
	4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and olfactory functions in male mouse models with AAV2-mediated α-s...
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent...
T36903	Rasagiline-13C3 (mesylate)	Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is se...
T83894	4A7C-301-Nurr1 Agonist	4A7C-301-Nuclear Receptor-Related 1
	The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity...

Compounds

α-Synuclein (61-75)

Target: Stearoyl-CoA Desaturase (SCD)

α-Synuclein inhibitor 6

T61644

Synonym:

Target:

α-Synuclein inhibitor 8

T72314

Synonym:

Target:

α-Synuclein inhibitor 3

T61404

Synonym:

Target:

α-Synuclein inhibitor 4

T61611

Synonym:

Target:

α-Synuclein inhibitor 7

T61920

Synonym:

Target:

α-Synuclein inhibitor 5

T62131

Synonym:

Target:

α-Synuclein inhibitor 9

T78842

Synonym:

Target:

α-Synuclein (61-95) (human)

T80118

Synonym:

Target:

PROTAC α-synuclein degrader 5

T79250

Synonym:

Target: PROTACs

Dyrk1A/α-synuclein-IN-2

T62226

Synonym:

Target:

α-Synuclein (61-75) (TFA)

T76199

Synonym:

Target:

Dyrk1A/α-synuclein-IN-1

T62096

Synonym:

Target:

PROTAC α-synuclein degrader 3

T78629

Synonym:

Target: PROTACs

tau protein/α-synuclein-IN-1

Synonym: (R)-NPT200-11,UCB0599,DLX-313

20S Proteasome activator 1

PBT434 methanesulfonate

T72280

Synonym:

Target:

Synucleozid hydrochloride (502139-01-7 free base)

T13049L

Synonym: Synucleozid hydrochloride,NSC 377363 hydrochloride

Rasagiline-13C3 (mesylate)

T36903

Synonym: Rasagiline-13C3 (mesylate)

Target:

4A7C-301-Nurr1 Agonist

T83894

Synonym: 4A7C-301-Nuclear Receptor-Related 1

Target:

Cat No.	Product Name	Synonyms	Targets
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T7441	Cuminaldehyde	Cuminic aldehyde,Cuminal	Endogenous Metabolite
	Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essenti...		Endogenous Metabolite
T5S2357	Acetylcorynoline	(+)-Corynoline Acetate,O-Acetylcorynoline	Antifungal
	1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3...		Antifungal
T72962	Sycosterol A
	Sycosterol A is an α-synuclein (α-syn) inhibitory sterol .
TN2149	Reynosin		BCL , Others , TNF
	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regu...		BCL , Others , TNF
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer. It facilitates the removal of alpha-synuclein by activating the Akt/mT...

Natural Products

Onjisaponin B

TN1140

Synonym:

Target: AMPK, mTOR, Autophagy

Cuminaldehyde

T7441

Synonym: Cuminic aldehyde,Cuminal

Target: Endogenous Metabolite

Acetylcorynoline

T5S2357

Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline

Target: BCL, Others, TNF

Corynoxine hydrochloride

T75438

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-06460	Alpha-Synuclein Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPJ-00683	SNCA Protein, Mouse, Recombinant	Mouse	E. coli
	Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist...
TMPY-06318	Alpha-Synuclein Protein,Human,Recombinant (H50Q)	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's ...
TMPJ-00023	SNCA Protein, Human, Recombinant (His)	Human	E. coli
	Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist...