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Results for "
tri611
" in TargetMol Product Catalog- Inhibitors & Agonists1
- PROTAC Products1
TRI-611
T2175273117940-39-0
TRI-611 is an oral, blood-brain barrier-penetrating ALK molecular chaperone degrader. TRI-611 specifically binds to E3 ligases, recruits and marks oncogenic ALK fusion proteins, and mediates their selective degradation via the ubiquitin-proteasome system. TRI-611 induces tumor regression in xenograft models of ALK-positive NSCLC. TRI-611 is equally effective in TKI-resistant tumor models. TRI-611 is suitable for use in studies of ALK-positive non-small cell lung cancer and TKI-resistant tumors.
- $68
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