myostatin inhibitory peptide-2

Myostatin inhibitory peptide 2 is a 24-amino-acid peptide derived from amino acids 20-43 of the mouse myostatin prodomain, and serves as a potent myostatin inhibitor. Myostatin inhibitory peptide 2 binds directly to myostatin with high affinity (Kd=35.9 nM), blocks the binding of myostatin to ActRII receptor, and inhibits the activation of downstream Smad2 signaling pathway. In mdx mice, a model of muscular dystrophy, Myostatin inhibitory peptide 2 significantly increases skeletal muscle weight and is suitable for research on mechanisms and interventions of muscular atrophy diseases.

Myostatin Inhibitory Peptide 2 (compd 2) TFA is a potent inhibitor of muscle growth suppressant with a dissociation constant (Kd) of 35.9 nM. It is utilized in the study of muscle atrophy diseases.