dihydrotestosterone

Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

Dihydrotestosterone-KLH is a hapten-carrier protein conjugate formed by coupling Dihydrotestosterone (DHT) to keyhole limpet hemocyanin (KLH). As a hapten, Diethylstilbestrol alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Dihydrotestosterone-KLH may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Dihydrotestosterone-BSA is a hapten-carrier protein conjugate formed by coupling Dihydrotestosterone (DHT) to bovine serum albumin (BSA). As a hapten, Dihydrotestosterone alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Dihydrotestosterone-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Dihydrotestosterone-d3 is a deuterated compound of Dihydrotestosterone. Dihydrotestosterone has a CAS number of 521-18-6.

5α-Dihydrotestosterone-d4 is a deuterated compound of 5α-Dihydrotestosterone. 5α-Dihydrotestosterone has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.

11-Ketodihydrotestosterone is a metabolite of 11β-Hydroxyandrostenedione. It is an active androgen and is also a potent androgen receptor (AR) agonist (Ki: 20.4 nM, EC50: 1.35 nM for human AR).

Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters.

(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.

4-Androsten-3-one-5-ene-17-carboxylic acid is a derivative of progesterone and functions as a 5α-reductase inhibitor. It prevents the transformation of testosterone into dihydrotestosterone in homogenates of the rat ventral prostate.

Neoaureothin, a bacterial metabolite found in Streptomyces, is an androgen receptor (AR) antagonist that inhibits dihydrotestosterone (DHT) binding to ARs (IC50 = 13 μM) and DHT-induced prostate-specific antigen expression in LNCaP cells (IC50 = 1.75 nM). It is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively), exhibits nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml), and increases survival of P. densiflora trees inoculated with B. xylophilus.

(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (±)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (±)-Equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).

Cioteronel is an antineoplastic compound with antiandrogenic activities. The antineoplastic action of CPC 10997 appears to be the inhibition of RNA synthesis in vitro. Although it blocks competitively the binding of dihydrotestosterone (DHT) to its protein receptor, it has no significant effects on either estrogen or progesterone receptors.

N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition to 5α-dihydrotestosterone and reducing AR protein levels [1].

Stanolone-d4 is a deuterated compound of Stanolone. Stanolone has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.

5α-Reductase is the enzyme responsible for converting testosterone into 5-α dihydrotestosterone (DHT), a potent androgen involved in male sexual differentiation. The 5α-reductase family comprises three subfamilies and five isozyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L.