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Search Results for " aromatase,estrogen "

Targets

14

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T7556 Fadrozole hydrochloride CGS 16949A Aromatase
Fadrozole hydrochloride (CGS 16949A) is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovaries of fish.
T4281 Endoxifen (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen Estrogen Receptor/ERR , Aromatase , Estrogen/progestogen Receptor , Parasite , Drug Metabolite
(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f...
T2280 Endoxifen (Z-isomer) Endoxifen Z-isomer Estrogen Receptor/ERR , EGFR , Potassium Channel , Estrogen/progestogen Receptor , HER
Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T6827L Endoxifen hydrochloride
Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for br...
T23549 YM 511 P450 , Aromatase
YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly ...
T11847L Liarozole R75251 dihydrochloride P450 , Retinoid Receptor
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...
T7197L Fadrozole HCl hydrate Fadrozole,CGS-16949A,Fadrozole hydrochloride hemihydrate,CGS16949A,CGS 16949A
Fadrozole is a selective inhibitor of aromatase. It also effective in the treatment of estrogen-dependent diseases including breast cancer.
T27868 LY 113174 LY-113174,LY113174
LY 113174, a novel nonsteroidal aromatase inhibitor, may prove useful in the treatment of estrogen-dependent diseases.
T71010 Norendoxifen
Norendoxifen, also known as 4-hydroxy-N, N-didesmethyltamoxifen, is a nonsteroidal aromatase inhibitor of the triphenylethylene group that was never marketed. It is an active metabolite of the selective estrogen receptor...
T11847 Liarozole dihydrochloride R75251 dihydrochloride Others
Liarozole dihydrochloride is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lya...
T71578 Endoxifen mesylate
Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot...
T83907 10-Chloroestra-1,4-diene-3,17-dione 10-chloro-1,4-Estradiene
10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor α (ERα) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aroma...
T35676 17β-hydroxy Exemestane
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (...
Cat No. Product Name Synonyms Targets
T1590 Letrozole CGS 20267 Aromatase , Autophagy
Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.
T3390 Obacunone Apoptosis , Aromatase , p38 MAPK
Obacunone has cytotoxicity in androgen-dependent human prostate Y cells. Obacunone exerts an antivirulence effect on S. Typhimurium and may serve as a lead compound for development of antivirulence strategies for S. Typh...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00956 Aromatase/CYP19A1 Protein, Human, Recombinant (His) Human E. coli
Aromatase/CYP19A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TargetMol