analgesic ability

1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 induced NOX activation and Smad signaling. 3. Decursin has anti-cancer activity , mediated suppression of the PKCα, MAPK and NF-κB pathways in MCF-7 cells. 4. Decursin exhibits cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity.

Muopioid receptor antagonist9 is a potent and highly selective μ-opioid receptor (MOR) antagonist with the ability to cross the blood-brain barrier, having a Ki value of 77.3 nM. It exhibits selectivity for the κ-opioid receptor (KOR) and δ-opioid receptor (DOR). This compound effectively blocks the analgesic effects of psychoactive substances and can reverse respiration depression induced by these substances in mice. Additionally, Muopioid receptor antagonist9 is applicable for research on opioid use disorder (OUD).

DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.

[Nphe1]Nociceptin(1-13)NH2 is a novel endogenous ligand for the nociceptin/orphanin FQ (NC) receptor, acting as a selective and competitive antagonist without any agonist effects. It binds specifically to recombinant nociceptin receptors with high affinity (pKi=8.4) and effectively blocks nociceptin's ability to inhibit cyclic AMP accumulation in CHO cells (pA2=6.0), showcasing potential as an analgesic agent.

RE-33 is an analgesic compound with the ability to penetrate the blood-brain barrier [1].

MFCD01827729 (ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE), also known as EMTPC, is a derivative of the amino acid thiophene, a heterocyclic aromatic compound. EMTPC has been investigated for its potential as an anti-inflammatory, analgesic and anticonvulsant drug, its potential as an anticancer drug and its ability to modulate the immune system.