6
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8697 | ZAP-180013 | Tyrosine Kinases , Tyrosinase | |
ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM). | |||
T32108 | HXJ42 | HXJ-42,HXJ 42 | Others |
HXJ42 is a PP1 analog that selectively and effectively acts on wild-type ZAP-70 (AS). | |||
T6266 | PP2 | AGL 1879,AG 1879,AGL 1879 | EGFR , Tyrosine Kinases , JAK , Src |
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2. | |||
T6277 | Doramapimod | BIRB 796 | Raf , p38 MAPK , Autophagy |
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. | |||
T4391 | Syk Inhibitor II dihydrochloride | Syk Inhibitor II (hydrochloride) | Others , Tyrosine Kinases , Syk , PKC , BTK |
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun... | |||
T81308 | RDN2150 | ||
RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69 and inhibiting the activation of CD4+ T cells, making it suit... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01096 | SLP-76 Protein, Human, Recombinant (His) | Human | E. coli |
Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cel... |