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Search Results for " zap-70 "

Targets

6

Compounds

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8697 ZAP-180013 Tyrosine Kinases , Tyrosinase
ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
T32108 HXJ42 HXJ-42,HXJ 42 Others
HXJ42 is a PP1 analog that selectively and effectively acts on wild-type ZAP-70 (AS).
T6266 PP2 AGL 1879,AG 1879,AGL 1879 EGFR , Tyrosine Kinases , JAK , Src
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
T6277 Doramapimod BIRB 796 Raf , p38 MAPK , Autophagy
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.
T4391 Syk Inhibitor II dihydrochloride Syk Inhibitor II (hydrochloride) Others , Tyrosine Kinases , Syk , PKC , BTK
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun...
T81308 RDN2150
RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69 and inhibiting the activation of CD4+ T cells, making it suit...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-01096 SLP-76 Protein, Human, Recombinant (His) Human E. coli
Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cel...
TargetMol