ulk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5403	ULK-101		Autophagy
	ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.		Autophagy
T2128	SBI-0206965	SBI0206965	Apoptosis , Autophagy
	SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.		Apoptosis , Autophagy
T8850	Sbp-7455		Autophagy
	SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.		Autophagy
T8322	BL-918		Autophagy
	BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.		Autophagy
T6899	MRT68921	MRT68921 HCl	Autophagy
	MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.		Autophagy
T9142	MRT68921 dihydrochloride		Autophagy
	MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).		Autophagy
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy
T8808L	LYN-1604 dihydrochloride	LYN-1604 2HCl（2216753-86-3 free base)	Apoptosis , Autophagy
	LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T9207	GW406108X	GW108X	Kinesin , Autophagy
	GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.		Kinesin , Autophagy
T4123	LYN-1604	LYN1604	Apoptosis , Autophagy
	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T63343	ULK1-IN-2		Apoptosis , Autophagy
	ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells....		Apoptosis , Autophagy
T69365	HMS607P03
	HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP...

Compounds

ULK-101

T5403

Target: Apoptosis, Autophagy

Synonym: MRT68921 HCl

Target: Autophagy

MRT68921 dihydrochloride

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

LYN-1604 dihydrochloride

T8808L

Synonym: LYN-1604 2HCl（2216753-86-3 free base)

Target: Apoptosis, Autophagy

GW406108X

T9207

Synonym: GW108X

Target: Kinesin, Autophagy

LYN-1604

T4123

Synonym: LYN1604

Target: Apoptosis, Autophagy

ULK1-IN-2

T63343

Synonym:

Target: Apoptosis, Autophagy

Cat No.	Product Name	Synonyms	Targets
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.

Cat No.

Product Name

Synonyms

Targets

T3981

Acacetin

4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Apoptosis , IAP , COX , Autophagy

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.

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Natural Products