Search Result

Search Results for " tyrosinase "

Targets

Compounds

103

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T73598	Tyrosinase
	Tyrosinase (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes [1] .
T78554	Tyrosinase-IN-12		Tyrosinase
	Tyrosinase-IN-12(Non-competitive tyrosinase inhibitor) is a potent non-competitive tyrosinase inhibitor with an IC50 of 49.33 ± 2.64 µM and a Ki of 31.25 ± 0.25 µM. Tyrosinase-IN-12 has significant antioxidant and free r...		Tyrosinase
T67939	Tyrosinase-IN-16
	Tyrosinase-IN-16 inhibited tyrosinase.
T60278	Tyrosinase-IN-2		Tyrosinase
	Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase, a copper-containing metalloenzyme pivotal for the catalytic step that limits the rate in melanin biosynthesis and enzymatic browning processes. This comp...		Tyrosinase
TP1623	[Asp371]-Tyrosinase (369-377), human
	Tyrosinase (369-377,YMDGTMSQV) is derived from the membrane protein tyrosinase by posttranslational conversion of the sequence YMNGTMSQV. Presentation of YMDGTMSQV in cells expressing full-length tyrosinase is TAP-(trans...
T39311	Tyrosinase-related Protein 2 (TRP-2) (181-188)
	Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from the tyrosinase-related protein 2 (TRP-2), specifically corresponding to residues 180-188. It is the primary epitope within TRP-2 that is recognized...
T60484	Tyrosinase-IN-4
	Tyrosinase-IN-4 (compound 34) is a potent tyrosinase inhibitor. As a promising target, tyrosinase inhibitors can be used as skin-whitening agents and food preservatives. Tyrosinase-IN-4 has the potential in the fields of...
T80910	Tyrosinase-IN-15		Tyrosinase
	Tyrosinase-IN-15 (Compound 39), with an IC50 of 7.12 μM and a Ki of 11.8 μM, functions as a tyrosinase inhibitor [1].		Tyrosinase
T61460	Tyrosinase-IN-3
	Tyrosinase-IN-3 (compound 54) is a powerful tyrosinase inhibitor, an enzyme involved in the key catalytic step of melanin biosynthesis and enzymatic browning. As a copper-containing metalloenzyme, tyrosinase plays a cruc...
T72786	Tyrosinase-IN-7
	Tyrosinase-IN-7, a potent inhibitor of tyrosinase, exhibits an IC50 value of 1.57 µM and demonstrates inhibition of cell growth with minimal cytotoxicity.
T72787	Tyrosinase-IN-8
	Tyrosinase-IN-8, a potent inhibitor of tyrosinase, demonstrates an inhibitory concentration (IC 50) value of 1.6 µM and exhibits low cytotoxicity while effectively inhibiting cell growth.
T60449	Tyrosinase-IN-1
	Tyrosinase-IN-1 (compound 90) is a potent tyrosinase inhibitor. As a promising target, tyrosinase inhibitors can be used as skin-whitening agents and food preservatives, thus having broad potential in the fields of food,...
T61817	Tyrosinase-IN-6
	Tyrosinase-IN-6 (Compound 4B) demonstrated the highest efficacy as a tyrosinase inhibitor (ic50 = 3.80 μM), in addition to exhibiting favorable antioxidant activity.
T72703	Tyrosinase-IN-11
	Tyrosinase-IN-11, a potent inhibitor of tyrosinase, exhibits IC50 values of 50 nM and 64 nM for L-tyrosinase and L-dopa (L-dopa), respectively. It demonstrates significant antioxidant activity coupled with low cytotoxici...
T80909	Tyrosinase-IN-19		Tyrosinase
	Tyrosinase-IN-19 (compound 9), a competitive tyrosinase inhibitor, exhibits potent antioxidant activities by neutralizing ROS, ABTS+, and DPPH radicals and demonstrates dose-dependent suppression of tyrosinase expression...		Tyrosinase
T61425	Tyrosinase-IN-5
	Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1].
T72720	Tyrosinase-IN-10
	Tyrosinase-IN-10 serves as a partially competitive inhibitor of tyrosinase, demonstrating an inhibition concentration (IC50) value of 1.6 μM against the enzyme's activity in lysates derived from human melanoma cells.
T79406	Tyrosinase-IN-14		Tyrosinase
	Tyrosinase-IN-14 (compound 7m), a tyrosinase inhibitor, modulates the enzyme's secondary structure to diminish its catalytic function, exhibits low cytotoxicity, and possesses anti-browning properties that effectively pr...		Tyrosinase
T79401	Tyrosinase-IN-13		Tyrosinase
	Tyrosinase-IN-13 (compound 3c), stemming from Flurbiprofen, acts as a potent non-competitive inhibitor of tyrosinase, exhibiting IC50 and Ki values of 68 μM and 36.3 μM respectively. This compound demonstrates cytotoxici...		Tyrosinase
T74243	Tyrosinase/elastase-IN-1
	Tyrosinase/elastase-IN-1, a triterpenoid extracted from the leaves of Rubus fraxinifolius, exhibits inhibitory activities against both tyrosinase and elastase enzymes.
T76410	Tyrosinase (206-214), human
	Tyrosinase (206-214), human (AFLPWHRLF), is a 9-amino acid peptide and an epitope of tyrosinase that can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL) [1].
T80911	Tyrosinase (192-200), human mouse
	Tyrosinase (192-200), a human mouse nonapeptide, is recognizable by cytolytic T cells (CTL) on the HLA-B44 molecule and is utilized in the research of melanoma-associated cancers [1].
T3567	SU 4942		Others
	SU-4942 is a modulator of tyrosine kinase signaling. SU-4942 has inhibitory effects on endothelial cell mitosis induced by VEGF and endothelial cell growth factor (ECGF).		Others
T3710	XMD16-5		Tyrosinase , PPAR
	XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is d...		Tyrosinase , PPAR
T8697	ZAP-180013		Tyrosine Kinases , Tyrosinase
	ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).		Tyrosine Kinases , Tyrosinase
T3709	XMD8-87	ACK1-B19	Tyrosinase , PPAR
	XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.		Tyrosinase , PPAR
T4182	Lavendustin B		Tyrosinase , transporter , HIV Protease
	Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived growth factor (LEDGF/p75).		Tyrosinase , transporter , HIV Protease
T7125	4-Butylresorcinol	Butylresorcinol	Tyrosinase
	4-Butylresorcinol (Butylresorcinol) is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent.		Tyrosinase
T10104	3,4-Dihydroxybenzylamine hydrobromide	NSC 263475 hydrobromide	Others , DNA/RNA Synthesis
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) inhibits DNA polymerase activity in melanoma cells and displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activit...		Others , DNA/RNA Synthesis
T1344	4-Chloro-4'-hydroxybenzophenone		Others
	4-Chloro-4'-hydroxybenzophenone inhibits tyrosinase and also acts as a free radical scavenger or antioxidant, reducing lipid and protein oxidation.		Others
T77011	Flanvotumab	20D7S,IMC 20D7S	Tyrosinase
	Flanvotumab (IMC-20D7S) is a humanized monoclonal antibody directed against tyrosinase-related protein (TYRP1).Flanvotumab exhibits potent antitumor activity and acts through natural killer-mediated and antibody-dependen...		Tyrosinase
T50049	4-Methylhistamine hydrochloride		Others
	4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in ...		Others
T77649	HTYR/AbTYR-IN-1		Tyrosinase
	hTYR/AbTYR-IN-1 is a dual hTYR/AbTYR inhibitor with inhibitory effects on hTYR and AbTYR, with IC50s of 5.4 μM and 3.52 μM, respectively. hTYR/AbTYR-IN-1 can be used for the study of hyperpigmentation and melanoma in hum...		Tyrosinase
T28035	MHY908
	MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.
T75714	Decapeptide-12
	Decapeptide-12, a competitive inhibitor of mushroom tyrosinase with an IC50 of 40 µM and a Kd of 61.1 μM for the C-terminal residue of tyrosinase, is a small oligopeptide that reduces melanin content in melanocytes by in...
T27358	FQ
	FQ is a novel reversible inhibitor of mixed-type tyrosinase.
T29898	Alpha-Methylcinnamaldehyde	Z-alpha-Methylcinnamaldehyde
	alpha-Methylcinnamaldehyde is an α-substituted derivative of Cinnamaldehyde, which can be used as an inhibitor of mushroom tyrosinase.
T12645	(R)-Trolox		Others
	(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor (Ki value of 0.83 mM and a ID50 value of 1.88 mM).		Others
T40846	3,5-Difluoro-L-tyrosine
	3,5-Difluoro-L-tyrosine is a functional and tyrosinase-resistant mimic of tyrosine, commonly utilized for evaluating the substrate specificity of protein tyrosine phosphatases (PTPs).
T70783	Azo-Resveratrol
	Azo-Resveratrol is an analog of Resveratrol used as a potent tyrosinase inhibitor.
T71873	Temechine hydrobromide
	Temechine hydrobromide is used for the identification of new diterpenoidal alkaloid leads as tyrosinase inhibitors.
TP1675	MTRP-2 (180-188)	mTRP-2 180-188
	This peptide is a TRP-tyrosinase-related protein. Its immunization results in effective induction of antitumor immunity.
T83925	(S)-(–)-Deoxyarbutin
	(S)-(–)-Deoxyarbutin, an isomer of deoxyarbutin, functions as a tyrosinase inhibitor, effectively inhibiting tyrosinase activity at a concentration of 74 µM.
T25807	MHY884	MHY 884,MHY-884
	MHY884 is an inhibitor of tyrosinase that acts by inhibiting UVB-induced activation of the NF-κB signaling pathway through the downregulation of oxidative stress.
T63219	Piceid 6″-O-azelaic acid ester
	Piceid 6″-O-azelaic acid ester exhibited strong intracellular tyrosinase inhibition and decolorization activity.
T71813	Cardanol diene
	Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E...
T76258	Tetrapeptide-30
	Tetrapeptide-30, a skin-brightening peptide comprised of four amino acids, functions as a tyrosinase inhibitor. It effectively lightens hyperpigmentation and evens skin tone by decreasing tyrosinase levels and preventing...
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory...
T83924	(R)-(+)-Deoxyarbutin
	(R)-(+)-Deoxyarbutin, an isomer of deoxyarbutin, acts as a tyrosinase inhibitor. Effective at a concentration of 21 µM, it diminishes tyrosinase activity and has been demonstrated to lighten the skin in hairless guinea p...
T37555	Cardanol triene
	Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal c...

Compounds

[Asp371]-Tyrosinase (369-377), human

Tyrosinase/elastase-IN-1

T74243

Synonym:

Target:

Tyrosinase (206-214), human

T76410

Synonym:

Target:

Tyrosinase (192-200), human mouse

Target: Tyrosinase, PPAR

ZAP-180013

T8697

Synonym:

Target: Tyrosine Kinases, Tyrosinase

XMD8-87

T3709

Synonym: ACK1-B19

Target: Tyrosinase, PPAR

lavendustin B

T4182

Synonym:

Target: Tyrosinase, transporter, HIV Protease

4-Butylresorcinol

T7125

Synonym: Butylresorcinol

Target: Tyrosinase

3,4-Dihydroxybenzylamine hydrobromide

T10104

Synonym: NSC 263475 hydrobromide

Target: Others, DNA/RNA Synthesis

4-Chloro-4'-hydroxybenzophenone

Synonym: 20D7S,IMC 20D7S

Target: Tyrosinase

4-Methylhistamine hydrochloride

alpha-Methylcinnamaldehyde

T29898

Synonym: Z-alpha-Methylcinnamaldehyde

3,5-Difluoro-L-tyrosine

Temechine hydrobromide

Synonym: mTRP-2 180-188

Synonym: MHY 884,MHY-884

Target:

Piceid 6″-O-azelaic acid ester

Cat No.	Product Name	Synonyms	Targets
TN2246	Swertiajaponin		Tyrosinase
	Swertiajaponin possesses antimicrobial activity.		Tyrosinase
T6463	Deoxyarbutin		Tyrosinase
	DeoxyArbutin(IC50=50 nM) inhibits tyrosinase activity reversibly.		Tyrosinase
TN1928	Methyl rosmarinate		MMP , Anti-infection , Tyrosinase
	Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmarinate shows antioxidative, and antifungal activities. It has...		MMP , Anti-infection , Tyrosinase
T8087	Tropolone		Tyrosinase
	Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion		Tyrosinase
T5985	Glycolic acid		Tyrosinase , Endogenous Metabolite
	Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products		Tyrosinase , Endogenous Metabolite
T7966	3-O-Ethyl-L-ascorbic acid		Tyrosinase
	3-O-Ethyl-L-ascorbic acid is a cosmetic tyrosinase inhibitor with whitening ability and is a stabilized vitamin C derivative. It also has antioxidant properties.		Tyrosinase
TN1772	Isoastilbin		Anti-infection , Tyrosinase , Antibacterial
	Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, Isoastilbin has anti-acne an...		Anti-infection , Tyrosinase , Antibacterial
TN1545	D-Tyrosine		Tyrosinase
	D-Tyrosine, the D-isomer of tyrosine, acts as a negative regulator of melanin synthesis by inhibiting tyrosinase activity. Furthermore, D-Tyrosine also inhibits biofilm formation and induces the self-dispersal of biofilm...		Tyrosinase
T7052	Gnetol		Tyrosinase , COX , HDAC , AChR
	Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. ...		Tyrosinase , COX , HDAC , AChR
T4S0998	Trifolirhizin		TNF , Tyrosinase
	Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer ...		TNF , Tyrosinase
TN1441	Beta-Tocopherol		ERK , MAPK
	Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).		ERK , MAPK
T1738	Taxifolin	(+)-Taxifolin,Dihydroquercetin,(+)-Dihydroquercetin	VEGFR , TNF , Tyrosinase , Adrenergic Receptor , Autophagy
	Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
T6S1597	Mulberroside A		TNF , Tyrosinase , Interleukin
	1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...		TNF , Tyrosinase , Interleukin
T5552	Methyl cinnamate		Tyrosinase , Antibacterial , AMPK
	Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.		Tyrosinase , Antibacterial , AMPK
T3734	3',4'-Dihydroxyacetophenone	Qingxintong,4-Acetylpyrocatechol	Tyrosinase , Platelet aggregation
	3',4'-Dihydroxyacetophenone (Qingxintong) is an active constituent of Chinese medicine. It is platelet aggregation Inhibitor and also has anti-arrhythmia activity.		Tyrosinase , Platelet aggregation
T4S1658	Benzoyloxypaeoniflorin	Benzoyloxypeoniflorin	NF-κB , Tyrosinase
	Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation.		NF-κB , Tyrosinase
T0473	Arbutin	Uva,p-Arbutin,p-Arbutin,β-Arbutin	Tyrosinase
	Arbutin (p-Arbutin)(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the formation of melanin.		Tyrosinase
T4587	Mirificin	BCP10902,Puerarin Apioside	Tyrosinase
	Mirificin (BCP10902) is an active ingredient in Tongmai formula (TMF) which is a well-known Chinese medicinal preparation. Anti-oxidant.		Tyrosinase
T2S0973	2-Methoxycinnamic acid	AI3-11206,o-Methoxycinnamic acid	Tyrosinase
	1. 2-Methoxycinnamic acid (o-Methoxycinnamic acid) can enhance inhibition of tyrosinase activity.		Tyrosinase
T5980	2-Ketoglutaric acid		Tyrosinase , Endogenous Metabolite
	2-Ketoglutaric acid is a key molecule in the tricarboxylic acid cycle,is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.		Tyrosinase , Endogenous Metabolite
T2A2524	2-Hydroxy-4-methoxybenzaldehyde	4-Methoxysalicylaldehyde	Tyrosinase , Antibacterial
	2-Hydroxy-4-methoxybenzaldehyde (4-Methoxysalicylaldehyde) is a chemical compound and an isomer of Vanillin. 2-Hydroxy-4-methoxybenzaldehyde(4-Methoxysalicylaldehyde) could be used to synthesis Urolithin M7. 2-hydroxy-4-...		Tyrosinase , Antibacterial
T3737	3-(2,4-Dihydroxyphenyl)propanoic acid	Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid	Tyrosinase
	3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) is a predicted metabolite generated by BioTransformer1 that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is generated by abkar1...		Tyrosinase
T3745	3,4-Dimethoxyphenol	4-Hydroxyveratrole,3,4-dimethoxyphel	Tyrosinase
	3,4-Dimethoxyphenol (4-Hydroxyveratrole) is an active biochemical.		Tyrosinase
T3S1068	Oxyresveratrol	trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene	Tyrosinase , Autophagy , HSV
	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid...		Tyrosinase , Autophagy , HSV
TN1296	5-Feruloylquinic acid	5-O-Feruloylquinic acid,5-FQA	Tyrosinase , Sirtuin
	5-Feruloylquinic acid (5-FQA) is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated with aging.		Tyrosinase , Sirtuin
T4911	α-Arbutin	4-hydroxyphenyl-D-lucopyranoside,alpha-Arbutoside,alpha-Arbutin	Tyrosinase
	α-Arbutin (4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening.		Tyrosinase
TCS1709	BENZYLACETONE	4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone	Tyrosinase
	Benzylacetone (4-Phenyl-2-butanone) is an aromatic compound extracted from incense wood. Benzylacetone has appetite-enhancing and exercise-reducing properties. Benzylacetone has a strong and reversible anti-mushroom tyro...		Tyrosinase
TN2698	2,3-Dihydroisoginkgetin		Tyrosinase
	2,3-Dihydroisoginkgetin is a Tyrosinase inhibitor with 36.84% inhibition at 0.1 mM.		Tyrosinase
T4920	2-Ketoglutaric acid Sodium	Oxoglutaric acid,AKG,2-oxoglutarate monobasic,α-Ketoglutaric acid sodium salt	Tyrosinase , Endogenous Metabolite
	2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination...		Tyrosinase , Endogenous Metabolite
TN6784	Ethyl rosmarinate	Methyl rosmarinate	MMP , Tyrosinase , Glucosidase
	Methyl rosmarinate (Methyl rosmarinate) inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).		MMP , Tyrosinase , Glucosidase
T5889	Kojic acid		Tyrosinase , Parasite
	Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase.		Tyrosinase , Parasite
T0176	Isobarbaloin	Aloin,Aloin-A,Barbaloin-A	Tyrosinase
	Isobarbaloin (Barbaloin-A) (Aloin) is a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.		Tyrosinase
T20488	4-Isopropylbenzoic acid	NSC1907,NSC-1907,NSC 1907,Cumic acid	Antifungal
	4-Isopropylbenzoic acid (Cumic acid) is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and unco...		Antifungal
TN3231	Pratol	7-Hydroxy-4'-methoxyflavone	Others
	Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic.		Others
TN2078	Pinocembrin chalcone	2',4',6'-Trihydroxychalcone,Pinocembrinchalcone	Calcium Channel , Tyrosinase , Antibacterial , Antifection
	Pinocembrin chalcone is an inhibitor of tyrosinase with antimutagenic effects. Pinocembrin chalcone can be used in studies about the prevention of gastric ulcers.
T15753	Licraside	Licuraside	Tyrosinase
	Licraside is a tyrosinase inhibitor with an IC50 of 0.072 mM for monophenolase and can be used in studies about antibrowning and depigmenting agents.		Tyrosinase
T7438	3,5-Dimethoxyphenol	Phloroglucinol dimethyl ether	Tyrosinase
	3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.		Tyrosinase
T2742	Aloin	Barbaloin,Barbalin,Aloin-A,Aloin(mixture of A&B),Barbaloin-A	Tyrosinase
	Aloin (Aloin-A)(mixture of A&B), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.		Tyrosinase
TN1705	Glycyrrhisoflavone		MAO , Tyrosinase , NO Synthase , Immunology/Inflammation related
	Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
T0501	Mequinol	4-Hydroxyanisole,Leucobasal,4-Methoxyphenol	Others
	Mequinol (Leucobasal) is a synthetic derivate of hydroquinone and depigmenting agent. Although the exact mechanism of the depigmenting effects of mequinol remains unclear, it may exert its effect by oxidation of tyrosina...		Others
T5755	Aloesin		Tyrosinase
	Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.		Tyrosinase
T6389	Anacardic Acid	6-pentadecylsalicylic Acid,Hydroginkgolic acid	Others , Epigenetic Reader Domain , Histone Acetyltransferase , Antibacterial
	Anacardic Acid (6-pentadecylsalicylic Acid) is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostagland...
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC
T3676	Sesamol	1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol	Apoptosis , AMPK
	Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig...		Apoptosis , AMPK
T3S0645	N-trans-Feruloyltyramine	Feruloyltyramine,N-Feruloyltyramine,Moupinamide	Others , COX
	1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...		Others , COX
T40080	(±)-Taxifolin	(±)-Dihydroquercetin	Antioxidant , Tyrosinase
	(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark, with anti-tyrosinase and anti-fibrotic activity.Taxifoli...		Antioxidant , Tyrosinase
T3810	Saikosaponin B2		Others , HCV Protease
	Saikosaponin B2 acts on HCV E2 and inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells. Saikosaponin B2 (5 μM) induces differentiation of B16 melanoma cells, with...		Others , HCV Protease
TN2601	12-O-Methylcarnosic acid		Reductase
	12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...		Reductase
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
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Natural Products

Target: MMP, Anti-infection, Tyrosinase

Target: Tyrosinase, Endogenous Metabolite

3-O-Ethyl-L-ascorbic acid

Target: Anti-infection, Tyrosinase, Antibacterial

Target: Tyrosinase, COX, HDAC, AChR

Trifolirhizin

T4S0998

Synonym:

Target: TNF, Tyrosinase

Synonym: (+)-Taxifolin,Dihydroquercetin,(+)-Dihydroquercetin

Target: VEGFR, TNF, Tyrosinase, Adrenergic Receptor, Autophagy

Mulberroside A

T6S1597

Synonym:

Target: TNF, Tyrosinase, Interleukin

Methyl cinnamate

T5552

Synonym:

Target: Tyrosinase, Antibacterial, AMPK

3',4'-Dihydroxyacetophenone

T3734

Synonym: Qingxintong,4-Acetylpyrocatechol

Target: Tyrosinase, Platelet aggregation

Benzoyloxypaeoniflorin

T4S1658

Synonym: Benzoyloxypeoniflorin

Target: NF-κB, Tyrosinase

Arbutin

T0473

Synonym: Uva,p-Arbutin,p-Arbutin,β-Arbutin

Target: Tyrosinase

Mirificin

T4587

Synonym: BCP10902,Puerarin Apioside

Target: Tyrosinase

2-Methoxycinnamic acid

T2S0973

Synonym: AI3-11206,o-Methoxycinnamic acid

Target: Tyrosinase, Endogenous Metabolite

2-Hydroxy-4-methoxybenzaldehyde

T2A2524

Synonym: 4-Methoxysalicylaldehyde

Target: Tyrosinase, Antibacterial

3-(2,4-Dihydroxyphenyl)propanoic acid

T3737

Synonym: Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid

Target: Tyrosinase

3,4-Dimethoxyphenol

T3745

Synonym: 4-Hydroxyveratrole,3,4-dimethoxyphel

Target: Tyrosinase

Oxyresveratrol

T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

5-Feruloylquinic acid

TN1296

Synonym: 5-O-Feruloylquinic acid,5-FQA

Target: Tyrosinase, Sirtuin

α-Arbutin

T4911

Synonym: 4-hydroxyphenyl-D-lucopyranoside,alpha-Arbutoside,alpha-Arbutin

Target: Tyrosinase

BENZYLACETONE

TCS1709

Synonym: 4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone

Target: Tyrosinase

2,3-Dihydroisoginkgetin

TN2698

Synonym:

Target: Tyrosinase

2-Ketoglutaric acid Sodium

T4920

Synonym: Oxoglutaric acid,AKG,2-oxoglutarate monobasic,α-Ketoglutaric acid sodium salt

Target: Tyrosinase, Endogenous Metabolite

ethyl rosmarinate

TN6784

Synonym: Methyl rosmarinate

Target: MMP, Tyrosinase, Glucosidase

Kojic acid

T5889

Synonym:

Target: Tyrosinase, Parasite

Isobarbaloin

T0176

Synonym: Aloin,Aloin-A,Barbaloin-A

Target: Tyrosinase

4-Isopropylbenzoic acid

T20488

Synonym: NSC1907,NSC-1907,NSC 1907,Cumic acid

Target: Antifungal

Pratol

TN3231

Synonym: 7-Hydroxy-4'-methoxyflavone

Target: Others

Pinocembrin chalcone

TN2078

Synonym: 2',4',6'-Trihydroxychalcone,Pinocembrinchalcone

Target: Calcium Channel, Tyrosinase, Antibacterial, Antifection

Synonym: Phloroglucinol dimethyl ether

Target: Tyrosinase

Aloin

T2742

Synonym: Barbaloin,Barbalin,Aloin-A,Aloin(mixture of A&B),Barbaloin-A

Target: MAO, Tyrosinase, NO Synthase, Immunology/Inflammation related

Mequinol

T0501

Synonym: 4-Hydroxyanisole,Leucobasal,4-Methoxyphenol

Synonym: 6-pentadecylsalicylic Acid,Hydroginkgolic acid

Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial

2,5-Dihydroxyacetophenone

TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP

Target: ERK, NF-κB, Tyrosinase

Isosilybin A

TN1804

Synonym:

Target: Apoptosis, Tyrosinase, PPAR, ABC

Sesamol

T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol

Target: Apoptosis, AMPK

N-trans-Feruloyltyramine

T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide

Target: Others, COX

(±)-Taxifolin

T40080

Synonym: (±)-Dihydroquercetin

Target: Antioxidant, Tyrosinase

Saikosaponin B2

T3810

Synonym:

Target: Others, HCV Protease

12-O-Methylcarnosic acid

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02269	Tyrosinase/TYR Protein, Human, Recombinant (His)	Human	Yeast
	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan...
TMPH-02270	Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melan...
TMPH-02751	DCT Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	DCT Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01608	DCT Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).

Tyrosinase/TYR Protein, Human, Recombinant (His)

TMPH-02269

Species: Human

Expression System: Yeast

Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO)

TMPH-02270

Species: Human

Expression System: E. coli

DCT Protein, Mouse, Recombinant (His & SUMO)

TMPH-02751

Species: Mouse

Expression System: E. coli

DCT Protein, Human, Recombinant (His & Myc & SUMO)

TMPH-01608

Species: Human

Expression System: E. coli