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Cat No. | Product Name | Synonyms | Targets |
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T9192 | BIIB068 | BTK | |
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases. | |||
T8316 | 1V209 | TLR7 agonist T7 | TLR |
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. | |||
T6649 | (S)-(+)-Rolipram | (S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram | Apoptosis , PDE |
(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. | |||
T0137 | Mirtazapine | 6-Azamianserin,Org3770 | Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor |
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... | |||
T16501 | PF-3644022 | p38 MAPK , Serine Protease , MAPK | |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... | |||
T36127 | TNF-α Antagonist | ||
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact sit... | |||
TP1626 | TNF-α (46-65), human | ||
Human TNF alpha (46-65) peptide. | |||
T9034 | MK2-IN-3 | MK2 Inhibitor III | MAPK |
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis | |||
T71726 | TNFalpha-IN-S10 | ||
TNFalpha-IN-S10 is an inhibitor of TNF-α. | |||
T19584 | TNF-α (31-45), human | Others | |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
TP1537 | TNF-α (10-36), human | ||
TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response. | |||
T20033 | Direct Violet 1 | NSC75778,NSC 75778,Airedale Violet ND,NSC-75778,Direct Violet N,CCRIS 2413 | SARS-CoV |
Direct Violet 1 (CCRIS 2413) is an agent of dye. | |||
T19584L | TNF-α (31-45), human acetate | TNF-α (31-45), human acetate(144796-71-4 free base) | Others |
TNF-α (31-45), human acetate is a peptide of tumor necrosis factor-α. | |||
T9537 | N'-Nitro-D-arginine | N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid | Others |
N'-Nitro-D-arginine (N'-Nitro-D-arginine) is a Building Block. | |||
T7162 | R1487 Hydrochloride | R1487 (Hydrochloride) | p38 MAPK , Autophagy |
R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α. | |||
TP1636 | TNF-α (31-45), human TFA (144796-71-4 free base) | TNF-α (31-45), human TFA | |
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
TP1669 | TNF-α (46-65), human TFA (144796-72-5 free base) | TNF-α (46-65), human TFA | |
TNF-α (46-65), human (TFA) is a peptide of human TNF-α. | |||
TP1479 | TNF-α (10-36), human (TFA) (144796-70-3 free base) | TNF-α (10-36), human (TFA) | |
TNF-α (10-36), human (TFA) is a peptide of human TNF-α. | |||
T4637 | R-7050 | TNF-α Antagonist III | TNF |
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα. | |||
T29857 | Alethine | β-Alethine | TNF |
Alethine (β-Alethine) is a small molecule compound with antitumour activity and is used to treat tumours and infections. The alethine-induced up-regulation of TNFα increases the cytotoxicity of T cells. | |||
T1934 | Bay 11-7085 | BAY 11-7083 | Apoptosis , IκB/IKK , Ferroptosis , NF-κB |
Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM). | |||
T14848 | C 87 | Others , TNF | |
C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities. | |||
T1902 | BAY 11-7082 | BAY 11-7821 | Apoptosis , Others , IκB/IKK , DUB , Autophagy |
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM). | |||
T61111 | UCB-5307 | TNF | |
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas... | |||
T4403 | AX-024 hydrochloride | AX-024 HCl | IL Receptor , TNF , COX , IFNAR , Interleukin |
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. | |||
T76711 | Golimumab | MK-8259,SCH 900259,CNTO-148 | TNF |
Golimumab (CNTO-148) is a potent humanized anti-TNFα IgG1κ monoclonal antibody.Golimumab has anti-inflammatory and anticancer activity, inhibits the production of IL-6 and IL-1β, and induces apoptosis.Golimumab can be us... | |||
T36524 | IKK2-IN-4 | 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV | IκB/IKK , TNF |
IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS. | |||
T38361 | GSK717 | IL Receptor , NOD | |
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretio... | |||
T24185 | IW-927 | IW927,IW 927 | |
IW-927 is a potent and selective TNFα/TNFRc1 interaction antagonist. | |||
T27615 | INUB | ||
iNUB is a NEMO-Ub binding inhibitor. iNUB inhibits TNFα induced NF-κB signaling and has selectively toxic to IKK/NF-κB dependent ABC-DLBCL. | |||
T25525 | IDT | ||
IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model. | |||
T40321 | TNF-α-IN-6 | ||
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM). | |||
T27687 | JNJ525 | JNJ 525,JNJ-525 | |
JNJ525 is an inhibitor of TNFα. JNJ525 inhibits protein function via an aggregation-based mechanism. JNJ525 prevents the formation of TNFα complexes with TNFR1 and TNFR2, the apparent IC50 values for the inhibition of co... | |||
T77126 | Ozoralizumab | ||
Ozoralizumab (ATN-103), a humanized trivalent nanobody compound, comprises two anti-human TNFα nanobodies along with an anti-human serum albumin (HSA) nanobody, acting as an anti-TNFα humanized antibody. This compound is... | |||
T77179 | Remtolumab | ||
Remtolumab (ABT-122), a dual-variable domain immunoglobulin, neutralizes tumor necrosis factor α (TNFα) and IL-17A, demonstrating dual inhibition of both. This compound is utilized in rheumatoid arthritis (RA) research [... | |||
T61810 | Anti-inflammatory agent 16 | ||
Anti-inflammatory agent 16 (compound 14) is a highly effective peptidomimetic with potent anti-inflammatory properties. It effectively reduces the expression levels of TNFα, NO, CD40, and CD86 [1]. | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in... | |||
T68321 | AS1940477 | ||
AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo... | |||
T71240 | AS 703026 | ||
AS 703026 has been shown to inhibit LPS-induced TNFα production in macrophages/monocytes as well as protect from LPS-induced endotoxin shock. AS 703026 may be useful as an anti-inflammatory therapy for COPD patients. | |||
T27150 | Dersalazine sodium | UR12746,Dersalazine,UR 12746S (sodium salt),UR-12746S (sodium salt),UR-12746 | |
Dersalazine, a PAF antagonist and TNFα inhibitor, is used potentially for the treatment of ulcerative colitis. It showed anti-inflammatory effect in reactivated colitis in rats, as evidenced by a significant reduction in... | |||
T78991 | Biotin-labeled ODN 1585 sodium | ||
Biotin-labeled ODN 1585 (sodium) serves as a potent inducer of IFN and TNFα production and facilitates the assessment of CpG ODN cellular uptake and localization through detection with a biotin system and light microscop... | |||
T16477 | PF-03715455 | p38 MAPK | |
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respectiv... | |||
T10298 | AMG-548 hydrochloride (864249-60-5 free base) | AMG-548 hydrochloride | p38 MAPK |
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibi... | |||
T68266 | BMS-751324 | ||
BMS-751324, a p38α MAPK inhibitor, features a carbamyl-methyl linkage precursor with esters and phosphate functional groups from hydroxyphenylacetic acid (HPA). It effectively reduces foot swelling and suppresses LPS-ind... | |||
T10298L | AMG-548 | p38 MAPK | |
AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole b... | |||
T79170 | Immuno modulator-1 | ||
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound e... | |||
T36042 | 17(R)-HDHA | ||
Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when ex... | |||
T61604 | PKC-IN-4 | ||
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-... | |||
T78992 | FITC-labeled ODN 1585 sodium | ||
FITC-labeled ODN 1585 (sodium) effectively induces IFN and TNFα production and serves to assess CpG ODN cellular uptake and localization through confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or ... | |||
T75010 | TD1092 | ||
TD1092, a pan-IAP degrader, effectively degrades cIAP1, cIAP2, and XIAP, catalyzing the activation of Caspase 3/7 and fostering apoptosis in cancer cells through IAP degradation. It also obstructs the TNFα-mediated NF-κB... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5834 | Myrcene | Others | |
Myrcene is a terpene that has been found in Cannabis and has antioxidative properties. | |||
T3918 | Ginsenoside Rb3 | Gypenoside IV | NF-κB , COX , NO Synthase |
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA. | |||
TN1637 | Eurycomalactone | Anti-infection , NF-κB | |
Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in... | |||
T2878 | Ginsenoside Rd | Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII | P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite |
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. | |||
T8852 | Tubuloside B | Apoptosis , Others | |
The neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells. | |||
T7917 | 4'-Hydroxychalcone | 2-Benzal-4-Hydroxyacetophenone | Proteasome |
4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity | |||
T79961 | Aloeresin G | ||
Aloeresin G, a chromone glycoside isolated from Aloe, exhibits a moderate inhibitory effect on TNFα-induced NF-κB transcriptional activity, evidenced by an IC50 of 40.02 μM [1]. | |||
T79962 | Aloenin aglycone | Others | |
Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglyco... | |||
TN3614 | Cearoin | ERK , BCL , PARP , IκB/IKK , TNF , NF-κB , ROS , Caspase | |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of... | |||
TN5880 | Mesuol | ||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and p... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01294 | TNF alpha Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-01697 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR... | |||
TMPK-00583 | TNF alpha Protein, Ferret, Recombinant (His) | Ferret | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPY-02535 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPK-00119 | TNF alpha Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPK-00121 | TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPK-00120 | TNF alpha Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system developm... | |||
TMPY-05187 | TNF alpha Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-01696 | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFR... | |||
TMPY-01639 | TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th... | |||
TMPJ-00779 | TNF alpha Protein, Rabbit, Recombinant | Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor ty... | |||
TMPK-00749 | PGLYRP1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPK-00745 | PGLYRP1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPJ-00287 | TNF RII Protein, Human, Recombinant (hFc) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino a... | |||
TMPJ-00288 | TNF RII Protein, Human, Recombinant (mFc) | Human | Human Cells |
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino a... | |||
TMPY-01176 | CIAP1 Protein, Human, Recombinant (Avi) | Human | E. coli |
The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP r... |
Cat No. | Product Name | ||
---|---|---|---|
L9810 | Anti-Fibrosis Compound Library | 1180 compounds | |
A unique collection of 1180 potential anti-fibrosis compounds, can be used in HTS and HCS; |