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Search Results for " tmp "

Targets

31

Compounds

6

Natural Products

14

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13172L1 TMP-778 ROR
TMP-778 is a selective inverse agonist of RORγt.
T3983 TMP195 TFMO 2,TMP 195 HDAC
TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.
T13174 TMPyP4 tosylate TMP 1363 DNA/RNA Synthesis , Telomerase
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
T31017 Coumarin-TMP-Halo Coumarin TMP Halo,CTH
Coumarin-TMP-Halo is a specific fluorescent protein labeling agent.
T36126 TMP-153
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
T34893 TMP-NVOC-Halo TNH
TMP-NVOC-Halo is a caged protein labeling agent.
T1857 TMP269 HDAC
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.
T78534 NVOC cage-TMP-Halo Others
NVOC cage-TMP-Halo is a photoactivatable, cell-permeable inducer of protein dimerization that enables rapid and reversible modulation of protein localization within living cells, with applications in dynamic cellular pro...
T80972 TNH TMP-NVOC linker-Halo
TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].
T24899 Trimosulfa Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa
Trimosulfa is a fixed antibiotic combination that widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.
T83821 Thymidine-5'-O-(α,β-methylene)diphosphate sodium α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP
Thymidine-5’-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM). It serves as a precursor in the synthesis of α,β-methylene-2’-deo...
T17108 TMP920 ROR
TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T13172L TMP778 Others
TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).
T13172 TMP780 ROR
TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T60080 TMPH 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate AChR
TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.
T13173 TMPA Others , AMPK
TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.
T40732 TMPD dihydrochloride
TMPD dihydrochloride is an active substrate of enzymatically convert redox and an electron donor for the reduction of heme peroxidases.
T61796 MtTMPK-IN-1
MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demon...
T61573 MtTMPK-IN-5
MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhib...
T61781 MtTMPK-IN-6
MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T35966 Mn(III)TMPyP
Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-...
T27314 Fe-TMPyP
Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T63657 MtTMPK-IN-9
MtTMPK-IN-9 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) (IC50: 48 μM).MtTMPK-IN-9 has submicromolar activity against Mycobacterium but no significant cytotoxicity.MtTMPK-IN-9 can be use...
T23462 TMPH hydrochloride Others
neuronal nicotinic ACh receptors (nAChRs) antagonist
T63491 MtTMPK-IN-8
MtTMPK-IN-8 is a moderately potent inhibitor of Mycobacterium thymidylate kinase (MtbTMPK) with no significant cytotoxicity, exhibiting submicromolar activity (MICs = 0.78-9.4 μM) against Mycobacterium and capable of bei...
T28986 TMPPAA
TMPPAA is an allosteric agonist of 5-HT3 receptor.
T63639 MtTMPK-IN-7
MtTMPK-IN-7 is a moderately potent inhibitor of Mycobacterium brevis thymidylate kinase (MtbTMPK) (IC50: 47 μM).MtTMPK-IN-7 exhibits submicromolar activity against Mycobacterium brevis with MICs ranging from 2.3 to 4.7 μ...
T62897 MtTMPK-IN-3
MtTMPK-IN-3 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) with an IC50 value of 0.12 μM. It also demonstrates inhibitory activity against Mtb H37Rv with a MIC of 12.5 μM an...
T61780 MtTMPK-IN-4
MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory...
T78238 4′-DTMP 4-Demethyltrimethoprim DHFR , Antifungal
4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.
T62305 MtTMPK-IN-2
MtTMPK-IN-2 (compound 15), a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), demonstrates an IC50 value of 1.1 μM. This compound effectively inhibits Mtb H37Rv with a minimum inhibitory conce...

Compounds

TMP-778
T13172L1
Synonym:
Target: ROR
TMP195
T3983
Synonym: TFMO 2,TMP 195
Target: HDAC
TMPyP4 tosylate
T13174
Synonym: TMP 1363
Target: DNA/RNA Synthesis, Telomerase
Coumarin-TMP-Halo
T31017
Synonym: Coumarin TMP Halo,CTH
Target:
TMP-153
T36126
Synonym:
Target:
TMP-NVOC-Halo
T34893
Synonym: TNH
Target:
TMP269
T1857
Synonym:
Target: HDAC
NVOC cage-TMP-Halo
T78534
Synonym:
Target: Others
TNH
T80972
Synonym: TMP-NVOC linker-Halo
Target:
Trimosulfa
T24899
Synonym: Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa
Target:
Thymidine-5'-O-(α,β-methylene)diphosphate sodium
T83821
Synonym: α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP
Target:
TMP920
T17108
Synonym:
Target: ROR
TMP778
T13172L
Synonym:
Target: Others
TMP780
T13172
Synonym:
Target: ROR
TMPH
T60080
Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate
Target: AChR
TMPA
T13173
Synonym:
Target: Others, AMPK
TMPD dihydrochloride
T40732
Synonym:
Target:
MtTMPK-IN-1
T61796
Synonym:
Target:
MtTMPK-IN-5
T61573
Synonym:
Target:
MtTMPK-IN-6
T61781
Synonym:
Target:
Mn(III)TMPyP
T35966
Synonym:
Target:
Fe-TMPyP
T27314
Synonym:
Target:
MtTMPK-IN-9
T63657
Synonym:
Target:
TMPH hydrochloride
T23462
Synonym:
Target: Others
MtTMPK-IN-8
T63491
Synonym:
Target:
TMPPAA
T28986
Synonym:
Target:
MtTMPK-IN-7
T63639
Synonym:
Target:
MtTMPK-IN-3
T62897
Synonym:
Target:
MtTMPK-IN-4
T61780
Synonym:
Target:
4′-DTMP
T78238
Synonym: 4-Demethyltrimethoprim
Target: DHFR, Antifungal
MtTMPK-IN-2
T62305
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T4730 Thymidine-5'-monophosphate disodium salt Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT Others , Endogenous Metabolite
Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) is found in DNA. In mammalian cells, thymidine deprivation induces chromosome aberrations such as chromatid breaks, chromatid interchanges, and chromosome frag...
T4558 Trioxsalen Trimethylpsoralen,Trioxysalen,Trisoralen DNA Alkylator/Crosslinker , DHFR
Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...
T7892 ATMP Others
ATMP is a phosphonic acid with chelating properties. It is an antiscalant.
T0572 Methyl 3,4,5-trimethoxybenzoate Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,Trimethylgallic acid methyl ester Others
Methyl 3,4,5-trimethoxybenzoate (Methyl EudesMate) is the intermediate of antibacterial efficiency medicine trimethoprim.
T83320 4'-Demethylpodophyllotoxone
4'-Demethylpodophyllotoxone, an intermediate in the biotransformation pathway of Alternaria alternata S-f6, undergoes further modification with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP). This modification yields a novel ...
T75540 Ipomoeassin F
Ipomoeassin F, a selective and potent inhibitor of endoplasmic reticulum (ER) protein translocation, targets the Sec61 complex's pore-forming subunit (Sec61α) at the ER membrane. It inhibits the ER membrane translocation...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00499 TMP21 Protein, Human, Recombinant (mFc) Human HEK293
TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long r...
TMPH-02236 TMPRSS2 Protein, Human, Recombinant (E. coli, His) Human E. coli
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
TMPH-02238 TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated Human E. coli
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPH-02239 TMPRSS4 Protein, Human, Recombinant (His & Myc) Human E. coli
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
TMPY-04985 TMPRSS11D Protein, Human, Recombinant (His) Human HEK293
TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated ...
TMPY-04928 TMPRSS11B Protein, Human, Recombinant (His) Human HEK293
TMPH-02235 TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) Human in vitro E. coli expression system
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
TMPH-03643 TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) Treponema phagedenis E. coli
TMPY-01041 Compound TMPY-01041
TMPJ-00960 TMPO Protein, Human, Recombinant (His) Human E. coli
Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domai...
TMPH-02234 TMPRSS11A Protein, Human, Recombinant (His) Human E. coli
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
TMPH-02237 TMPRSS2 Protein, Human, Recombinant (His & Myc) Human HEK293
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that shows proteolytic activity toward the hyale...
TMPH-02945 TMPRSS4 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
TMPH-03291 FABP3 Protein, Rat, Recombinant (His & Myc) Rat HEK293
Tmp may serve as a porin or transport protein for large molecules.
TargetMol