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By Target- 5-HT Receptor
- MT Receptor(1)
- Melatonin Receptor(1)
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Results for "
S20098
" in TargetMol Product Catalog- Inhibitors & Agonists2
Agomelatine
Valdoxan, Thymanax, S-20098
T1445138112-76-2
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
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Agomelatine hydrochloride
S-20098 hydrochloride
T605231176316-99-6In house
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki values of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Additionally, Agomelatine hydrochloride is a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native (porcine) and cloned human 5-HT2C receptors, respectively [2].
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